Entry
Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II;
uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating);
elongation 3beta-GalNAc-transferase;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to beta-D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->3)-[N-acetyl-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R 3-beta-N-acetyl-D-glucosaminyltransferase;
B3GNT3 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] 3-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] = UDP + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] [RN:
R04636 R05901 ]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:
C00043 ];
3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
Product
UDP [CPD:
C00015 ];
3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
Comment
The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 2 structure of O-glycans.
History
EC 2.4.1.146 created 1984, modified 2018
Orthology
K07970 beta-1,3-N-acetylglucosaminyltransferase 3
Genes
MCC : 114674034(B3GNT3) 719221
PKL : 118722609 118725871(B3GNT3)
SHON : 118975180 118975182
AJM : 119043950 119046818(B3GNT3) 119046819
PDIC : 114503731 114503735
PHAS : 123828315 123828458
TALA : 116963233 122153644
PMUR : 107285005 107285006 107296837(B3GNT3) 114922368
PRAF : 128400762 128405712(B3GNT3)
HCG : 128341521(B3GNT3) 128343789
XLA : 108703715(b3gnt3.2.S) 108711807 734264(b3gnt3.2.L)
XTR : 100145701(b3gnt3.2) 100380117(b3gnt3.1) 100494334 101733889 116409851
NPR : 108790801 108793753 108803023
RTEM : 120909662 120909687 120914440 120933672 120933692
BBUF : 120989390(B3GNT3) 121009144
BGAR : 122919843 122920562(B3GNT3)
MUO : 115480102(B3GNT3) 115480542
GSH : 117350860 117365631(B3GNT3) 117365632 117365798
DRE : 100002020(b3gnt3.2) 561172(b3gnt3.4)
SANH : 107665060 107700302(b3gnt3)
CCAR : 109083431 109099585
CAUA : 113049247 113077616 113099571
CGIB : 127963990 128018881
PTET : 122350844(b3gnt3.4)
LROH : 127159074 127169401 127169402
OMC : 131545379(b3gnt3.4) 131546315
PPRM : 120474104(b3gnt3.4) 120474110
MAMB : 125279505 125280378 125280419 125280600
MASI : 127414726 127423798 127423799
TROS : 130568603(b3gnt3.4)
IPU : 108265513 108265514 108265849 108266016 108266017 128632865
IFU : 128607259 128607260 128608235 128608236 128608237 128608240
SMEO : 124399388 124400092 124400431
TFD : 113634256 113634260 113642616 113642617 113642618 113642619 113642620 125146324
TVC : 132853478 132853519 132853763 132854077
CMAO : 118812996 118812997 118812998 118813000 118813001 118814006 118814119 118814120 118817469
TFS : 130528986 130528987 130528989
TNG : GSTEN00019098G001 GSTEN00019099G001 GSTEN00019100G001
LCO : 104935378 109139021(b3gnt3) 109139346 109139347
PGEO : 117444957 117445064
GACU : 117544206 117544235 117544258
ELY : 117253529 117263620 117264498
PLEP : 121941118 121952728
AFB : 129092171 129094357 129113928
MSAM : 119900537 119900538 119900539 119917039
SCHU : 122878174 122878175 122878176 122884902
CUD : 121512695 121519212 121519214 121519215
ALAT : 119028474 119028475 119029000
ONL : 100700249 100710618 102077342(b3gnt3)
OAU : 116328445 116328458 116331915 116333906
OLA : 101163432 101173163 101173646 101175309
OML : 112138882 112139123 112142676 112142717 112150918 112150945
CSAI : 133457845 133458528 133459734 133460319
XMA : 102222047 102226121 102235218(b3gnt3) 111606492
XCO : 114137712 114137713 114150430 114151525 114152730
XHE : 116713044 116713045 116725213 116725996 116727933
PRET : 103463427 103463431 103475708 103476783
PFOR : 103129919 103129923 103133540 103133955
PLAI : 106937802 106937900 106947686 106955559
PMEI : 106906127 106914022 106914028 106914127
GAF : 122838849 122838850 122842547 122845157
PPRL : 129360191 129360192 129360194 129368864 129375276 129379706
CVG : 107095630 107103340(b3gnt3) 107103343 107103671 107104833
CTUL : 119773651 119786226 119786238 119787603 119787742 119790866
GMU : 124858982 124873366 124874498 124876850
NFU : 107376009 107386572 107392806
KMR : 108234252 108234256 108243045 108247418 119616708
ALIM : 106519220 106519221 106533410
NWH : 119407675 119407676 119420122 119430271
MCEP : 125009341 125009989 125018706
CSEM : 103395334 103395738 103395759 103399385
SSEN : 122780488 122781014 122781015
HHIP : 117760258 117760259 117760260 117760575 117760577
HSP : 118120691 118121259 118121338 118121467
SMAU : 118300122 118317900
LCF : 108881191 108881192 108893170
SDU : 111218271(b3gnt3) 111235274
SLAL : 111669970(b3gnt3) 111670022
XGL : 120790634 120791330 120802899
BSPL : 114852890 114854074 114854075 114854125 114854126 114854127 114854343 114854344 114854629 114854649
SASA : 106573871(b3gnt3) 106578060 106613654
OTW : 112250760(b3gnt3.4) 112252159
OGO : 123996683 123998437 124007935
CCLU : 121577321 123481027
ELS : 105007499 105011432(b3gnt3) 105031420
AANG : 118221742 118226430
PSPA : 121301356 121301670
ARUT : 117401222 117966163 117966195 117966263 117966282 117966310 117968039 117972057
PSEX : 120515032 120537847
LERI : 129711209 129716043
PMRN : 116943159 116950398 116950418 116951898
LRJ : 133342421 133350119 133352502
» show all
Taxonomy
Reference
Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
Journal
Reference
Authors
Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K
Title
Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.146