KEGG   ENZYME: 2.4.1.148
Entry
EC 2.4.1.148                Enzyme                                 
Name
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV;
uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B;
core 4 beta6-GalNAc-transferase;
core 6beta-GalNAc-transferase B;
UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R 6-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-N-acetyl-D-galactosaminyl-R [RN:R03514 R05915]
Reaction(KEGG)
R03514 R05915(G);
(other) R05910(G)
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-D-galactosaminyl-R [CPD:C01306]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->6)-[N-acetyl-beta-D-glucosaminyl-(1->3)]-N-acetyl-D-galactosaminyl-R [CPD:C04917]
Comment
cf. EC 2.4.1.102 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase), EC 2.4.1.146 (beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) and EC 2.4.1.147 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase).
History
EC 2.4.1.148 created 1984
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec01100  Metabolic pathways
Reference
1  [PMID:6226356]
  Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
  Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
  Journal
Carbohydr Res 120:3-16 (1983)
DOI:10.1016/0008-6215(83)88002-1
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.148
IUBMB Enzyme Nomenclature: 2.4.1.148
ExPASy - ENZYME nomenclature database: 2.4.1.148
BRENDA, the Enzyme Database: 2.4.1.148
CAS: 95978-15-7

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (10)   
   KEGG COMPOUND (4)   
   KEGG GLYCAN (6)   
Chemical reaction (5)   
   KEGG REACTION (3)   
   KEGG RCLASS (2)   
Protein sequence (835)   
   UniProt (816)   
   SWISS-PROT (13)   
   RefSeq(pep) (6)   
DNA sequence (6)   
   RefSeq(nuc) (6)   
Protein domain (1)   
   InterPro (1)   
All databases (861)   

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