Entry
Name
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase;
Lewis-negative alpha-3-fucosyltransferase;
plasma alpha-3-fucosyltransferase;
guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase;
galactoside 3-fucosyltransferase;
GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase;
GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase;
GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase;
GDP-beta-L-fucose:(1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosaminyl-R [RN:
R03519 ]
Reaction(KEGG)
Substrate
GDP-beta-L-fucose [CPD:
C00325 ];
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R [CPD:
C00694 ]
Product
GDP [CPD:
C00035 ];
beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-D-glucosaminyl-R [CPD:
C01311 ]
Comment
Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC
2.4.1.65 , 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.
History
EC 2.4.1.152 created 1984, modified 2002, modified 2019
Pathway
ec00515 Mannose type O-glycan biosynthesis
ec00601 Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603 Glycosphingolipid biosynthesis - globo and isoglobo series
Orthology
K03663 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
K20151 alpha(1,3/1,4) fucosyltransferase
Genes
MFOT : 126489140 126503347
MDO : 100014877 100020278(FUT9)
CUCA : 104062423(FUT9) 104062435
PMUR : 107292255(FUT9) 107297567
CTIG : 120307698(FUT9) 120316867
TSR : 106541661(FUT9) 106554991
PGUT : 117660780(FUT9) 117675804
APRI : 131194201 131194305(FUT9)
PTEX : 113438218 113455380(FUT9)
NSS : 113411458(FUT9) 113419257
XLA : 100337597(fut9.S) 108716340(fut9.L)
DRE : 100093713(fut9b.5) 100124609(zgc:165582) 503885(fut9d) 792063(ft2) 796410(fut9a)
SRX : 107751748 107752528 107752989 107752990 107754429 107755789
SANH : 107670988 107670991 107680752 107682543 107682550 107683254(fut9) 107693061 107699637 107699665
SGH : 107549854 107552177 107552178 107552179 107552180 107553051 107553052 107560043 107564944 107583473
CCAR : 109061376 109064072 109069167 109069172 109069186 109071560 109097854
CAUA : 113052735 113052738 113052797 113052798 113059359 113060727 113071724 113078773 113101286 113106950 113106951 113106952 113119816 113120213 113120219
CGIB : 127933587 127975993
LROH : 127158696 127163221 127180032(fut9a)
MAMB : 125263849 125268489(fut9a)
CIDE : 127498841 127508167 127508168 127508211 127517319 127517321 127517806
MASI : 127410320 127411026 127415354 127415856 127423745 127451725 127452256 127455443
TROS : 130549985 130560777(fut9a) 130561595 130567626 130567790 130568125 130568156 130568662
TDW : 130406933 130407251 130425560 130426158(zgc:165582) 130436627(fut9a) 130440168
MANU : 129414503 129414504 129414505 129414506 129414507 129414509 129414510 129414765 129414889 129416899 129417693 129417874(fut9a) 129429740 129430475 129430481 129443847
IPU : 108256900 108263097 108270007(fut9a) 108274821(si:ch1073-440p11.2)
IFU : 128600794 128612722(fut9a) 128618306
PHYP : 113523898 113525256 113525258 113533973 113541870 113546219
SMEO : 124376144 124376256 124389712(fut9a) 124402243
TFD : 113651290(fut9a) 113655369 113656736 113661962
TVC : 132852933(fut9a) 132864135
AMEX : 103029489 103039268 103042515(fut9) 103042542 103044280 111197691
CMAO : 118806077 118806109(zgc:165582) 118813491 118816337 118824091(fut9a)
EEE : 113569622 113576992 113583857 113587304 113587844 113587875 113590563(fut9) 113590641 113590697 113590698 113592116
CHAR : 105891587 105894836 105894945 105905740 105908260(fut9a) 105912471
TRU : 101067562 101073723 101074839 105419315 105419496 115246822 115246823 115247519 115247520 445968(fut9b) 445969(fut9c) 446062(fut9a)
TFS : 130520568 130540076 130540077
TNG : GSTEN00006850G001 GSTEN00006851G001 GSTEN00009901G001 GSTEN00010864G001 GSTEN00029413G001 GSTEN00031978G001 GSTEN00031979G001 GSTEN00031980G001
TBEN : 117476168(fut9a) 117477503
PGEO : 117454892 117467270(fut9a) 117467509 117468125
GACU : 117540600(fut9a) 117540609 117563028
PLEP : 121953153(fut9a) 121958066 121961113
ECRA : 117935606(fut9a) 117938449 117956386
ESP : 116669661 116674819 116679803 116701912 116702039 116702040
PFLV : 114546824(fut9) 114567778 114567781
GAT : 120817152 120826554 120833105(fut9a)
PPUG : 119210223 119210224 119210366 119210367 119210369 119210370 119210372 119218705 119219414 119227768(fut9a)
CLUM : 117725115(fut9a) 117738986 117739046
PSWI : 130197951 130200771 130202001(fut9a)
CUD : 121524205 121526025(fut9a)
ALAT : 119015233 119034243(fut9a)
ONL : 100697219 100697405 100703945 100707879 100708150 100708772 106098048 106098049 109204044 109204126
OAU : 116311514 116317002 116317003 116326060 116326090
OLA : 100302422(fut9a) 100302423(fut9b) 100302424(fut9c)
OML : 112142744 112142760(fut9a) 118597874
CSAI : 133462023(fut9a) 133462381 133462457 133462904 133462905
XMA : 102222498 102225778 102231995 111612181
XCO : 114134012 114134013 114134015
PRET : 103457330 103458746 103458791
PFOR : 103154983 103154988 107832863
PLAI : 106937698 106964672
PMEI : 106906607 106906618 106906628
CVG : 107096914 107096915 107096916 107096920
CTUL : 119775109 119775123 119775134(fut9a) 119775173
GMU : 124855798 124855799 124855957 124856049
NFU : 107392154 107392156(fut9)
KMR : 108233304 108237367(fut9a)
ALIM : 106518428 106518446(fut9)
CSEM : 103378711(fut9) 103382673 103382674 103382681 103382682 103394628 103394629 103394630 103394631
POV : 109631852 109636489(fut9)
SSEN : 122783199(fut9a) 122786685 122786687 122786690 122786812
HHIP : 117755521(fut9a) 117757654 117757729
HSP : 118101583 118101620 118117070(fut9a)
SMAU : 118286474(fut9a) 118288601 118291861 118291985 118317708
LCF : 108874965(fut9a) 108876746 108876755 108889252
SDU : 111223224 111223389 111224570 111224641 111226005(fut9)
SLAL : 111651020(fut9) 111656473 111656503 111656904 111656933
SBIA : 133513262 133513278 133513281 133513302 133513319 133513682 133513683
PEE : 133412733 133412734 133413153
PTAO : 133488198 133488249
BPEC : 110153654(fut9) 110164782 110165578
SASA : 100195769(fut9) 106561893 106564979 106571726 106571727 106576449 106576450 106596297 106596632 106601669 106606824 106607721(fut9) 106608151 106608177 106608180 106608181 106608194 106609044 106609585 106610592
STRU : 115162344 115162448 115162603 115164203 115171580 115174563 115174576 115179998 115199077 115199078 115199079 115201968 115202820 115204446 115208496
OTW : 112217886 112217898 112217900 112217903 112217904 112218062 112226226 112237397 112250498 112250512 112256439 112263440 112265903 112267801 121838771 121845275
OMY : 100136100(fut9) 110486734 110490571 110493783 110499900 110505253 110506253(fut9a) 110520969 110522510 110522523 110522524 110522526 110522527 110529796 110529812 110538683
OGO : 123991672 123991676 123995340 123995352 123995354 123995355 123995559 123995717 123995761 123995782 123995784 123995921 123995930 123998685 124015049 124016913 124035936 124045201
ONE : 115104355 115107338 115107343 115113439 115116763 115119926 115124479 115132924 115138268 115139182 115140449 115140450 115140508 115143587
OKI : 109866133 109866434 109866436 109866568 109866588 109878152 109878575 109882974 109892020 109893572 109895583 109896427 109900903 109901404
OKE : 118368551(fut9a) 118370408 118370409 118370410 118370413 118378153 118379216 118383332 118386794 118387215 118389107 118392551 118398479 118402518 127930096 127931423 127931424
SALP : 111954144 111954634 111969172 111973023 111973326 111980394 112068670 112068681 112072440 112080443 112080722
SNH : 120019384 120019385 120019502 120019551 120019553 120019570 120022436 120023361 120024210 120024535 120025172(fut9a) 120032330 120032346 120034273 120034279 120049410
CCLU : 121539685 121540918 121542454 121544444 121548569 121549223 121549224 121549347 121549351 121550909 121552496 121555421 121570375 121573051
ELS : 105006941(fut9) 105009923 105017585 105017586 105017587 105024824 106023859 114829408 114840820 114840824 114840825 114840826 114840827 114840828 114840829
SFM : 108929150 108929240 108929252 108935735
PKI : 111843009(fut9) 111849225
AANG : 118220399(fut9a) 118229305 118229916 118229917 118229919 118230399
LOC : 102691696 102694658(fut9) 107078908
PSPA : 121315239 121316605
ARUT : 117403347 117411608
CMK : 103178281 103178282(fut9a)
RTP : 109935545 109935547 109935548
CPLA : 122546605 122546617 122546648
LERI : 129697368 129697369
PVUL : 126808491 126814039
HEO : C694_01925 C694_03365
HPJ : jhp_0596(fucT) jhp_1002(fucU)
HPA : HPAG1_0636 HPAG1_1013
HPS : HPSH_03605 HPSH_05520
HHP : HPSH112_03760 HPSH112_05330
HHQ : HPSH169_03340 HPSH169_05305
HHR : HPSH417_03150 HPSH417_05070
HPG : HPG27_1018 HPG27_613
HPP : HPP12_0664(fucT) HPP12_1042
HPB : HELPY_0720(futB) HELPY_1046(futA)
HPL : HPB8_427(fucT1) HPB8_854(fucT7)
HPC : HPPC_03535 HPPC_05220
HCA : HPPC18_03150 HPPC18_05315
HPM : HPSJM_03315 HPSJM_05295
HPE : HPELS_01320 HPELS_03280
HPO : HMPREF4655_20949 HMPREF4655_21266
HPU : HPCU_03535 HPCU_05450
HEF : HPF16_0660(fucT) HPF16_1018(fucT)
HPF : HPF30_0312(fucT) HPF30_0677(fucT)
HEQ : HPF32_0329(fucT) HPF32_0668(fucT)
HEX : HPF57_0674(fucT) HPF57_1038(fucT)
HPT : HPSAT_03535 HPSAT_05130
HPX : HMPREF0462_0710 HMPREF0462_1089
HPH : HPLT_03250 HPLT_05320
HEG : HPGAM_03360 HPGAM_05520
HEP : HPPN120_03460 HPPN120_05205
HEU : HPPN135_03215 HPPN135_05490
HES : HPSA_03080 HPSA_05205
HCN : HPB14_03415 HPB14_05015
HPD : KHP_0670(fucTa) KHP_0977(fucTb)
HER : C695_01925 C695_03370
HEI : C730_01925 C730_03370
HPYA : HPAKL117_03085 HPAKL117_05025
HPYK : HPAKL86_04810 HPAKL86_05545
HPYO : HPOK113_0665 HPOK113_1036
HPYL : HPOK310_0645 HPOK310_0973
HPYB : HPOKI102_03755 HPOKI102_05640
HPYC : HPOKI112_03785 HPOKI112_05675
HPYE : HPOKI154_03330 HPOKI154_05345
HPYF : HPOKI422_03760 HPOKI422_05665
HPYG : HPOKI673_03310 HPOKI673_05330
HPYH : HPOKI828_03320 HPOKI828_05335
HPYJ : HPOKI898_03755 HPOKI898_05650
HPYR : K747_05675 K747_07345
HPYU : K751_02280 K751_04125
HPYM : K749_00370 K749_01980
HEM : K748_00470 K748_06920
HAIL : ASB7_00490 ASB7_03660
PPN : Palpr_1132 Palpr_1136
» show all
Taxonomy
Reference
Authors
Johnson PH, Yates AD, Watkins WM.
Title
Human salivary fucosyltransferases : evidence for two distinct alpha-3-L-fucosyltransferase activities one or which is associated with the Lewis blood group Le gene.
Journal
Reference
Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
Journal
Reference
Authors
Ma B, Wang G, Palcic MM, Hazes B, Taylor DE
Title
C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.152