KEGG   ENZYME: 2.4.1.153
Entry
EC 2.4.1.153                Enzyme                                 
Name
UDP-N-acetylglucosamine---dolichyl-phosphate N-acetylglucosaminyltransferase;
aglK (gene name);
dolichyl-phosphate alpha-N-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate [RN:R01008]
Reaction(KEGG)
R01008
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
dolichyl phosphate [CPD:C21212]
Product
UDP [CPD:C00015];
dolichyl N-acetyl-alpha-D-glucosaminyl phosphate [CPD:C04678]
Comment
The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, initiates N-linked glycosylation in that organism. The enzyme differs from the eukaryotic enzyme, which leaves one additional phosphate group on the dolichyl product (cf. EC 2.7.8.15, UDP-N-acetylglucosamine---dolichyl-phosphate N-acetylglucosaminephosphotransferase).
History
EC 2.4.1.153 created 1984, modified 2015
Orthology
K21304  UDP-N-acetylglucosamine---dolichyl-phosphate N-acetylglucosaminyltransferase
Genes
ECOM: QTN59_17270
NFT: FBF37_03960
MVL: KOY49_04685
MND: KOY48_05490
MJA: MJ_1222
MFE: Mefer_0585
MVU: Metvu_0231
MFS: MFS40622_0846
MIF: Metin_0407
MJH: JH146_0621
MESG: MLAUSG7_1148
MESA: MLASG1_0588
MIG: Metig_0745
MMP: MMP1170
MMQ: MmarC5_0417
MMX: MmarC6_1501
MMZ: MmarC7_0418
MMD: GYY_06695
MMAK: MMKA1_13480
MMAO: MMOS7_12780
MMAD: MMJJ_16750
MAE: Maeo_0734
MVN: Mevan_0490
MVO: Mvol_0745
MOK: Metok_0396
 » show all
Reference
1  [PMID:23624439]
  Authors
Larkin A, Chang MM, Whitworth GE, Imperiali B
  Title
Biochemical evidence for an alternate pathway in N-linked glycoprotein biosynthesis.
  Journal
Nat Chem Biol 9:367-73 (2013)
DOI:10.1038/nchembio.1249
  Sequence
[ag:ACE74694]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.153
IUBMB Enzyme Nomenclature: 2.4.1.153
ExPASy - ENZYME nomenclature database: 2.4.1.153
BRENDA, the Enzyme Database: 2.4.1.153
CAS: 63363-73-5

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (26)   
Protein sequence (35)   
   UniProt (34)   
   SWISS-PROT (1)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
Protein domain (2)   
   InterPro (2)   
All databases (73)   

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