KEGG ENZYME: 2.4.1.206

ENZYME: 2.4.1.206

Entry

EC 2.4.1.206                Enzyme

Name

lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase;
LA2 synthase;
beta1->3-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase;
lactosylceramide beta-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 3-beta-N-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase (configuration-inverting)

Reaction(IUBMB)

UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04493 R05971]

Reaction(KEGG)

R04493 R05971(G)

Substrate

UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]

Product

UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]

History

EC 2.4.1.206 created 1992

Pathway

ec00601

Glycosphingolipid biosynthesis - lacto and neolacto series

ec01100

Metabolic pathways

Orthology

K03766

beta-1,3-N-acetylglucosaminyltransferase 5

Genes

HSA:	84002(B3GNT5)

PTR:	735383(B3GNT5)

PPS:	100978128(B3GNT5)

GGO:	101133247(B3GNT5)

PON:	100438226(B3GNT5)

NLE:	100600878(B3GNT5)

HMH:	116479874(B3GNT5)

MCC:	705694(B3GNT5)

MCF:	102119427(B3GNT5)

MTHB:

126948416

MNI:	105480109(B3GNT5)

CSAB:

103221160(B3GNT5)

CATY:

105598969(B3GNT5)

PANU:

103875470(B3GNT5)

TGE:	112619511(B3GNT5)

MLEU:

105543949(B3GNT5)

RRO:	104664648(B3GNT5)

RBB:	108521055(B3GNT5)

TFN:	117083796(B3GNT5)

PTEH:

111523207(B3GNT5)

CANG:

105514444(B3GNT5)

CJC:	100411350(B3GNT5)

SBQ:	101035254(B3GNT5)

CIMI:

108311058(B3GNT5)

CSYR:

103273257(B3GNT5)

MMUR:

105855788(B3GNT5)

LCAT:

123630310(B3GNT5)

PCOQ:

105807012(B3GNT5)

OGA:	100964619(B3GNT5)

MMU:	108105(B3gnt5)

MCAL:

110311880(B3gnt5)

MPAH:

110329546(B3gnt5)

RNO:	116740(B3gnt5)

MCOC:

116085708(B3gnt5)

ANU:	117718282(B3gnt5)

MUN:	110564996(B3gnt5)

CGE:	100757919(B3gnt5)

MAUA:

101828920(B3gnt5)

PROB:

127226956(B3gnt5)

PLEU:

114684261(B3gnt5)

MORG:

121465068(B3gnt5)

MFOT:

126494571

AAMP:

119825701(B3gnt5)

NGI:	103726553(B3gnt5)

HGL:	101723270(B3gnt5)

CPOC:

100721740(B3gnt5)

CCAN:

109700297(B3gnt5)

DORD:

105998376(B3gnt5)

DSP:	122125084(B3gnt5)

PLOP:

125351931(B3gnt5)

NCAR:

124992586

MMMA:

107149442(B3gnt5)

OCU:

100352940

OPI:	101531304(B3GNT5)

TUP:	102489196(B3GNT5)

GVR:	103590094(B3GNT5)

CFA:	102154559(B3GNT5)

CLUD:

112662899(B3GNT5)

VVP:	112926242(B3GNT5)

VLG:	121477332(B3GNT5)

NPO:	129498581(B3GNT5)

AML:	100477043(B3GNT5)

UMR:	103676097(B3GNT5)

UAH:	113254536(B3GNT5)

UAR:	123778960(B3GNT5)

ELK:

111151247

LLV:

125100933

MPUF:

101689863(B3GNT5)

MNP:	132012008(B3GNT5)

MLK:	131824818(B3GNT5)

NVS:	122908738(B3GNT5)

ORO:	101385310(B3GNT5)

EJU:	114206948(B3GNT5)

ZCA:	113916714(B3GNT5)

MLX:	118006871(B3GNT5)

NSU:	110582392(B3GNT5)

LWW:	102748676(B3GNT5)

FCA:	101096409(B3GNT5)

PYU:	121034054(B3GNT5)

PCOO:

112849745(B3GNT5)

PBG:	122491684(B3GNT5)

PVIV:

125175241(B3GNT5)

LRUF:

124527038

PTG:	102956905(B3GNT5)

PPAD:

109275199(B3GNT5)

PUC:

125921143

AJU:

106967357

HHV:	120238546(B3GNT5)

BTA:	767899(B3GNT5)

BOM:	102284217(B3GNT5)

BIU:	109557599(B3GNT5)

BBUB:

102402441(B3GNT5)

BBIS:

105000000(B3GNT5)

CHX:	102189161(B3GNT5)

OAS:	132657129(B3GNT5)

BTAX:

128050688(B3GNT5)

ODA:	120871781(B3GNT5)

CCAD:

122444883(B3GNT5)

MBEZ:

129545452(B3GNT5)

SSC:	397599(B3GNT5)

CFR:	102514403(B3GNT5)

CBAI:

105063339(B3GNT5)

CDK:	105085901(B3GNT5)

VPC:	102545933(B3GNT5)

BACU:

103015740(B3GNT5)

BMUS:

118894318(B3GNT5)

LVE:	103079181(B3GNT5)

OOR:	101288601(B3GNT5)

DLE:	111173504(B3GNT5)

PCAD:

102979892(B3GNT5)

PSIU:

116752873(B3GNT5)

NASI:

112414693(B3GNT5)

ECB:	100058694(B3GNT5)

EPZ:	103558196(B3GNT5)

EAI:	106834539(B3GNT5)

MYB:	102250884(B3GNT5)

MYD:	102773368(B3GNT5)

MMYO:

118676517(B3GNT5)

MLF:	102423549(B3GNT5)

PKL:	118723208(B3GNT5)

EFUS:

103286766(B3GNT5)

MNA:	107541112(B3GNT5)

DRO:	112305059(B3GNT5)

SHON:

118974194(B3GNT5)

AJM:	119056467(B3GNT5)

PDIC:

114490514(B3GNT5)

PHAS:

123826778(B3GNT5)

MMF:	118617347(B3GNT5)

PPAM:

129076923(B3GNT5) 129077541

HAI:	109396440(B3GNT5)

RFQ:	117031256(B3GNT5)

PALE:

102892817(B3GNT5)

PGIG:

120592877(B3GNT5)

PVP:	105307283(B3GNT5)

RAY:	107507023(B3GNT5)

MJV:	108397663(B3GNT5) 118969379

TOD:	119257330(B3GNT5)

SARA:

101547751(B3GNT5)

SETR:

126012071(B3GNT5)

LAV:	100672153(B3GNT5)

TMU:

101342861

ETF:	101648984(B3GNT5)

DNM:	101446264(B3GNT5)

MDO:	103100021(B3GNT5)

GAS:	123242843(B3GNT5)

SHR:	100920203(B3GNT5)

AFZ:

127552926

PCW:	110204756(B3GNT5)

OAA:	100092498(B3GNT5)

GGA:	424960(B3GNT5)

PCOC:

116235418(B3GNT5)

MGP:	100544407(B3GNT5)

CJO:	107318134(B3GNT5)

TPAI:

128081849(B3GNT5)

LMUT:

125697370(B3GNT5)

NMEL:

110397816(B3GNT5)

APLA:

101791474(B3GNT5)

ACYG:

106032048(B3GNT5)

CATA:

118253166(B3GNT5)

AFUL:

116492581(B3GNT5)

TGU:	100224977(B3GNT5)

LSR:	110477686(B3GNT5)

SCAN:

103815322(B3GNT5)

PMOA:

120504286(B3GNT5)

OTC:	121336657(B3GNT5)

PRUF:

121353739(B3GNT5)

GFR:	102033487(B3GNT5)

FAB:	101810058(B3GNT5)

OMA:	130256803(B3GNT5)

PHI:	102111086(B3GNT5)

PMAJ:

107208796(B3GNT5)

CCAE:

111933377(B3GNT5)

CCW:	104687996(B3GNT5)

CBRC:

103625111(B3GNT5)

ETL:	114059482(B3GNT5)

ZAB:	102074404(B3GNT5)

ACHL:

103800712(B3GNT5)

SVG:	106850328(B3GNT5)

MMEA:

130574097(B3GNT5)

HRT:	120756999(B3GNT5)

FPG:	101915210(B3GNT5)

FCH:	102047405(B3GNT5)

CLV:	102087227(B3GNT5)

EGZ:	104123298(B3GNT5)

NNI:	104019580(B3GNT5)

PCRI:

104036519(B3GNT5)

PLET:

104624532(B3GNT5)

EHS:	104515661(B3GNT5)

PCAO:

104039867(B3GNT5)

ACUN:

113483221(B3GNT5)

TALA:

104359295(B3GNT5)

PADL:

103914981(B3GNT5)

AFOR:

103906196(B3GNT5)

ACHC:

115346758(B3GNT5)

HALD:

104318584(B3GNT5)

HLE:	104835125(B3GNT5)

AGEN:

126039964

GCL:

127019984

CCRI:

104163608(B3GNT5)

CSTI:

104550515(B3GNT5)

CMAC:

104483657(B3GNT5)

MUI:	104538829(B3GNT5)

BREG:

104635846(B3GNT5)

FGA:	104081777(B3GNT5)

GSTE:

104262352(B3GNT5)

LDI:	104354467(B3GNT5)

MNB:	103776933(B3GNT5)

OHA:	104336000(B3GNT5)

NNT:	104401102(B3GNT5)

SHAB:

115611523(B3GNT5)

DPUB:

104302983(B3GNT5)

PGUU:

104465309(B3GNT5)

ACAR:

104521930(B3GNT5)

CPEA:

104390257(B3GNT5)

AVIT:

104273160(B3GNT5)

CVF:	104295532(B3GNT5)

RTD:	128911165(B3GNT5)

CUCA:

104057839(B3GNT5)

TEO:	104375545(B3GNT5)

BRHI:

104489870(B3GNT5)

AAM:	106482228(B3GNT5) 106490128

AROW:

112968548(B3GNT5)

NPD:	112952548(B3GNT5)

TGT:	104578043(B3GNT5)

DNE:	112980139(B3GNT5)

SCAM:

104145656(B3GNT5)

ASN:	102383416(B3GNT5)

AMJ:	102563242(B3GNT5)

CPOO:

109308475(B3GNT5)

GGN:	109288030(B3GNT5)

PSS:	102462329(B3GNT5)

CMY:	102930607(B3GNT5)

CCAY:

125642177(B3GNT5)

DCC:	119861223(B3GNT5)

CPIC:

101944344(B3GNT5)

TST:	117882665(B3GNT5)

CABI:

116838564(B3GNT5)

MRV:	120372157(B3GNT5)

ACS:	100560177(b3gnt5)

ASAO:

132770470(B3GNT5)

PVT:	110086058(B3GNT5)

SUND:

121925223(B3GNT5)

PBI:	103056995(B3GNT5)

PMUR:

107299948(B3GNT5)

CTIG:

120298272(B3GNT5)

TSR:	106555717(B3GNT5)

PGUT:

117678144(B3GNT5)

APRI:

131200429(B3GNT5)

PTEX:

113439734(B3GNT5)

NSS:	113422707(B3GNT5)

VKO:	123025603(B3GNT5)

PMUA:

114598037(B3GNT5)

PRAF:

128414818(B3GNT5)

ZVI:	118093490(B3GNT5)

HCG:	128349062(B3GNT5)

GJA:	107117663(B3GNT5)

STOW:

125437770(B3GNT5)

EMC:	129331790(B3GNT5)

XLA:	446540(b3gnt5.S) 496364(b3gnt5.L)

XTR:	394849(b3gnt5)

NPR:	108791305(B3GNT5)

RTEM:

120936798(B3GNT5)

BBUF:

120997929(B3GNT5)

BGAR:

122933656(B3GNT5)

MUO:	115478707(B3GNT5)

GSH:	117366333 117366335(B3GNT5)

DRE:	336526(b3gnt5a) 791470(b3gnt5b)

SRX:	107709072 107718888 107722519 107753797

SANH:

107656073 107656860 107674530 107681747

SGH:	107563744 107568627 107593139 107593805

CCAR:

109048047(b3gnt5) 109073985 109077565 109080378

CAUA:

113038448 113055021 113110956

CGIB:

127968083 128022450

PTET:

122353529(b3gnt5a) 122356742(b3gnt5b)

LROH:

127172916(b3gnt5a) 127175227(b3gnt5b)

OMC:	131524894(b3gnt5b) 131549228(b3gnt5a)

PPRM:

120468908(b3gnt5a) 120471465(b3gnt5b)

RKG:	130086675(b3gnt5a) 130097267(b3gnt5b)

MAMB:

125251550(b3gnt5b) 125256291(b3gnt5a)

CIDE:

127522518 127522655

MASI:

127425833 127428068 127440578 127442207

TROS:

130553767(b3gnt5b) 130570989(b3gnt5a)

TDW:	130409998(b3gnt5a) 130416054 130416158

MANU:

129427089(b3gnt5a) 129442629(b3gnt5b)

IPU:	100528972(b3gnt5a) 108267178(b3gnt5b)

IFU:	128609704(b3gnt5b) 128613394(b3gnt5a)

PHYP:

113532941 113540478

SMEO:

124386780(b3gnt5b) 124390966(b3gnt5a)

TFD:	113644057(b3gnt5b) 113657772(b3gnt5a)

TVC:	132847850(b3gnt5b) 132853530(b3gnt5a)

AMEX:

103022371 103033521

CMAO:

118819097(b3gnt5a) 118825566(b3gnt5b)

EEE:	113568141 113570158

CHAR:

105913197(b3gnt5a) 122131910

TRU:	101066739 101067076

TFS:	130528255(b3gnt5a) 130539335(b3gnt5b)

TNG:	GSTEN00014965G001 GSTEN00038809G001

LCO:

104920550

NCC:	104942412(b3gnt5)

TBEN:

117472154 117479812 117488738 117490961(b3gnt5a)

CGOB:

115007538 115022040

PGEO:

117445166(b3gnt5a) 117448370 117448371 117462804 117462806 117462807

GACU:

117545424 117546548 117554477 117558993(b3gnt5a)

EMAC:

134866657(b3gnt5b) 134869811(b3gnt5a)

ELY:	117254260 117271590(b3gnt5b)

EFO:	125895888 125902230(b3gnt5b)

PLEP:

121951648(b3gnt5b) 121962675(b3gnt5a)

SLUC:

116046159(b3gnt5b)

ECRA:

117954072(b3gnt5b)

ESP:	116699203(b3gnt5)

PFLV:

114565925(b3gnt5)

GAT:	120815575(b3gnt5b) 120823419(b3gnt5a)

PPUG:

119208572(b3gnt5b) 119216469

AFB:	129088963(b3gnt5b) 129113295

CLUM:

117729221(b3gnt5a) 117746989(b3gnt5b)

PSWI:

130193436 130197736(b3gnt5b)

MSAM:

119901256 119902323(b3gnt5b)

SCHU:

122877717(b3gnt5a) 122886266(b3gnt5b)

CUD:	121512670(b3gnt5a) 121519697

ALAT:

119011858(b3gnt5b) 119028402(b3gnt5a)

MZE:	101475629(b3gnt5) 101479343

ONL:	100706077(b3gnt5) 102082918

OAU:	116309332 116320433(b3gnt5b)

OLA:	101164751(b3gnt5)

OML:

112147620

CSAI:

133453036

XMA:	102225193(b3gnt5) 102236464

XCO:	114146530 114150713

XHE:	116721599(b3gnt5) 116726057

PRET:

103464035 103479067(b3gnt5)

PFOR:

103132032 103139965(b3gnt5)

PLAI:

106940453 106961899(b3gnt5)

PMEI:

106908586 106920602(b3gnt5)

GAF:	122838839(b3gnt5a) 122840609

PPRL:

129361882(b3gnt5b) 129379672(b3gnt5a)

CVG:	107082590(b3gnt5)

CTUL:

119782555

GMU:	124870190(b3gnt5b) 124873601(b3gnt5a)

NFU:	107384478 107387353

KMR:	108238228(b3gnt5b) 108250604(b3gnt5a)

ALIM:

106517288 106530178

NWH:	119414521(b3gnt5b) 119430697

AOCE:

111581474(b3gnt5) 111588986

MCEP:

125008797(b3gnt5a) 125011223(b3gnt5b)

CSEM:

103396140 103399979

POV:	109625816 109639539

SSEN:

122765522 122781213(b3gnt5a)

HHIP:

117760676(b3gnt5a) 117778636

HSP:	118117812 118120602(b3gnt5a)

SMAU:

118310392(b3gnt5b)

LCF:	108883761(b3gnt5b) 108896980

SDU:	111228747(b3gnt5) 111231897

SLAL:

111661239 111662612

XGL:	120790841(b3gnt5a) 120798536(b3gnt5b)

HCQ:	109520510(b3gnt5)

SSCV:

125984607

SBIA:

133510804(b3gnt5b)

PEE:	133411880(b3gnt5b)

PTAO:

133489310(b3gnt5b)

BPEC:

110161218 110173517 110173522

MALB:

109951382 109951962

BSPL:

114845185(b3gnt5b) 114854589

SJO:	128361273 128368770

SASA:

106568751 106584309 106598820(b3gnt5)

STRU:

115156662 115170056 115192478

OTW:	112227140 112248383 112251035 112260200

OMY:	110509000 110521586 110524457 110530057

OGO:	123996930 124010129 124037789 124042082

ONE:	115101832 115108447 115114145 115145031

OKI:	109872332 109875345 109897958 109902642

OKE:	118359115 118391374 118394438 118402346

SALP:

111957280 111972226(b3gnt5) 111975851 111979664

SNH:	120052528 120054870 120055482

CCLU:

121533387 121534984 121540229 121581440 121581442

ELS:	105011704 105028915

SFM:	108921630 108937393

PKI:	111854663(b3gnt5) 111860520

AANG:

118226264 118229676

LOC:	102683403(b3gnt5)

PSPA:

121322922 121327006

ARUT:

117417154 117422989

PSEX:

120532760(b3gnt5a)

LCM:	106702428(B3GNT5)

CMK:	103190900(b3gnt5a)

RTP:	109915865(b3gnt5a)

CPLA:

122555990(b3gnt5a)

HOC:	132821858(b3gnt5a)

LERI:

129703190(b3gnt5a)

PMRN:

116954633(B3GNT5)

LRJ:	133357621(B3GNT5)

BFO:

118432074

BBEL:

109461543

CIN:

104265549

SCLV:

120341604

LPIC:

129268186

OTU:	111415023 111419006

DMK:	116919378 116922449 116932905 116933809 116933909 116936133 123477442

RSAN:

119376234 119392862 119393728

RMP:

119162044

SDM:

118181413

BGT:	106054985 106068978

GAE:	121384290 121384451

CVN:

111127863

OED:

125658632

PMAX:

117324988 117326304 117333008 117342140 117342628 117342690 117343021

OSN:

115224368

» show all

Reference

1 [PMID:1825612]

Authors

Gottfries J, Percy AK, Mansson JE, Fredman P, Wikstrand CJ, Friedman HS, Bigner DD, Svennerholm L.

Title

Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas.

Journal

Biochim Biophys Acta 1081:253-61 (1991)
DOI:10.1016/0005-2760(91)90279-Q

Reference

2 [PMID:2960671]

Authors

Holmes EH, Hakomori S, Ostrander GK.

Title

Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1----3N-acetylglucosaminyltransferase.

Journal

J Biol Chem 262:15649-58 (1987)

Reference

3 [PMID:1901591]

Authors

Percy AK, Gottfries J, Vilbergsson G, Mansson JE, Svennerholm L.

Title

Glycosphingolipid glycosyltransferases in human fetal brain.

Journal

J Neurochem 56:1461-5 (1991)
DOI:10.1111/j.1471-4159.1991.tb02038.x

Other DBs

ExplorEnz - The Enzyme Database: