Entry
Name
GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase;
GumH;
AceA;
alpha1,3-mannosyltransferase AceA
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-mannose:D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase
Reaction(IUBMB)
GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol = GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol [RN:
R09733 ]
Reaction(KEGG)
Substrate
GDP-mannose [CPD:
C00096 ];
D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol [CPD:
C19856 ]
Product
GDP [CPD:
C00035 ];
D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol [CPD:
C19855 ]
Comment
In the bacterium Gluconacetobacter xylinus (previously known as Acetobacter xylinum) the enzyme is involved in the biosynthesis of the exopolysaccharide acetan [1]. In Xanthomonas campestris the enzyme is involved in the biosynthesis of the exopolysaccharide xanthan [5].
History
EC 2.4.1.252 created 2011
Orthology
K13657 alpha-1,3-mannosyltransferase
Genes
XFU : XFF4834R_chr26160(gumH)
XPH : XppCFBP6546_19500(XppCFBP6546P_19500)
XHD : LMG31886_17090(gumH)
GLC : JQN73_13805 JQN73_17575
AVV : RvVAT039_12260(gumH)
AVF : RvVAR031_32170(gumH)
REC : RHECIAT_CH0004338(aceC)
MAQU : Maq22A_1p38155(rfaG)
» show all
Taxonomy
Reference
Authors
Geremia RA, Roux M, Ferreiro DU, Dauphin-Dubois R, Lellouch AC, Ielpi L
Title
Expression and biochemical characterisation of recombinant AceA, a bacterial alpha-mannosyltransferase.
Journal
Sequence
Reference
Authors
Abdian PL, Lellouch AC, Gautier C, Ielpi L, Geremia RA
Title
Identification of essential amino acids in the bacterial alpha -mannosyltransferase aceA.
Journal
Sequence
Reference
Authors
Petroni EA, Ielpi L
Title
Isolation and nucleotide sequence of the GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase gene from Acetobacter xylinum.
Journal
Sequence
Reference
Authors
Lellouch AC, Watt GM, Geremia RA, Flitsch SL
Title
Phytanyl-pyrophosphate-linked substrate for a bacterial alpha-mannosyltransferase.
Journal
Reference
Authors
Katzen F, Ferreiro DU, Oddo CG, Ielmini MV, Becker A, Puhler A, Ielpi L
Title
Xanthomonas campestris pv. campestris gum mutants: effects on xanthan biosynthesis and plant virulence.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.252