Entry Name 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase;
Class Transferases;BRITE hierarchy
Sysname UDP-N-acetyl-alpha-D-glucosamine:2-deoxystreptamine N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB) UDP-N-acetyl-alpha-D-glucosamine + 2-deoxystreptamine = UDP + 2'-N-acetylparomamine [RN:
R08894 ]
Reaction(KEGG) Substrate UDP-N-acetyl-alpha-D-glucosamine [CPD:
C00043 ];
2-deoxystreptamine [CPD:
C02627 ]
Product Comment Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Unlike the enzyme from the bacterium Streptomyces kanamyceticus, which can also accept UDP-D-glucose [2] (cf. EC
2.4.1.284 , 2-deoxystreptamine glucosyltransferase), the enzyme from Bacillus circulans can only accept UDP-N-acetyl-alpha-D-glucosamine [1].
History EC 2.4.1.283 created 2012
Pathway ec00524 Neomycin, kanamycin and gentamicin biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology K13550 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase / 2-deoxystreptamine glucosyltransferase
Genes Taxonomy Reference Authors Yokoyama K, Yamamoto Y, Kudo F, Eguchi T
Title Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis.
Journal Sequence Reference Authors Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ
Title Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.4.1.283
