Entry
Name
rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,4/1,5-galactofuranosyltransferase;
arabinogalactan galactofuranosyl transferase 1;
GlfT1
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactofuranose:alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 4-beta/4-beta-galactofuranosyltransferase (configuration-inverting)
Reaction(IUBMB)
2 UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol = 2 UDP + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol (overall reaction);
(1a) UDP-alpha-D-galactofuranose + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol = UDP + beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol;
(1b) UDP-alpha-D-galactofuranose + beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol = UDP + beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol
Reaction(KEGG)
Substrate
UDP-alpha-D-galactofuranose [CPD:
C03733 ];
alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol [CPD:
C20416 ];
alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol;
beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol
Product
UDP [CPD:
C00015 ];
beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol;
beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol;
beta-D-galactofuranosyl-(1->5)-beta-D-galactofuranosyl-(1->4)-alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans-octacis-decaprenol
Comment
Isolated from the bacteria Mycobacterium tuberculosis and M. smegmatis, the enzyme has dual beta-(1->4) and beta-(1->5) transferase action. Involved in the formation of the cell wall in mycobacteria.
History
EC 2.4.1.287 created 2012, modified 2017
Pathway
ec00572 Arabinogalactan biosynthesis - Mycobacterium
Orthology
K16649 rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,3/1,4-galactofuranosyltransferase
Genes
HPIT : NCTC13334_00997(glfT1)
ABS : AZOBR_140059 AZOBR_40146
ABQ : ABAZ39_01435 ABAZ39_04995
ABF : AMK58_09060 AMK58_12400
AZT : TSH58p_12970 TSH58p_16510
AARE : D3093_04250 D3093_07765
MBO : BQ2027_MB3811(glft1)
MBAI : MB901379_04772(glfT1)
MKY : IWGMT90018_61170(glfT1)
MPHL : MPHLCCUG_00220(glfT1)
MTHN : 4412656_04377(glfT1)
MAUU : NCTC10437_05379(glfT1)
MFLV : NCTC10271_00231(glfT1)
MSAL : DSM43276_00180(glfT1)
MTER : 4434518_04024(glfT1)
CDIP : ERS451417_00134(glfT1)
CPP : CpP54B96_0115(glfT1)
CUN : Cul210932_0158(glfT1)
CUQ : Cul210931_0152(glfT1)
CUZ : Cul05146_0158(glfT1)
CUJ : CUL131002_0142c(glfT1)
CUS : CulFRC11_0153(glfT1)
CMIN : NCTC10288_02439(glfT1)
CRL : NCTC7448_00923(glfT1)
CPRE : Csp1_25980(glfT1_1) Csp1_27340(glfT1_2)
CCYS : SAMEA4530656_2412(glfT1)
CAUI : CAURIS_00635(glfT1)
CAUS : CAURIC_11085(glfT2)
NFR : ERS450000_04021(glfT1)
NAD : NCTC11293_00961(glfT1)
RRT : 4535765_00264(glfT1)
RCR : NCTC10994_02440(glfT1)
TPUL : TPB0596_44790(glfT1)
ARE : AL755_15720 AL755_15725
AAQ : AOC05_10180 AOC05_10185
ARW : MB46_10895 MB46_10900
ARU : ASPU41_19025 ASPU41_19030
AAGI : NCTC2676_1_01925(glfT1_1) NCTC2676_1_01928(glfT1_2)
PDEL : JCQ34_11825 JCQ34_12225
KVR : CIB50_0002204(glfT1)
NDK : I601_0162(glfT2_2) I601_0163(glfT1)
NOY : EXE57_06605 EXE57_06610
NOI : FCL41_12350 FCL41_12355
NOO : FE634_07235 FE634_07240
NSN : EXE58_13135 EXE58_13140
NANO : G5V58_15855 G5V58_15860
NARO : CFH99_18305 CFH99_18310
NAQU : ENKNEFLB_03324(glfT1_1) ENKNEFLB_03325(glfT1_2)
NOQ : LN652_18780 LN652_18785
NCQ : K6T13_04780 K6T13_04785
NMAR : HPC71_16275 HPC71_16280
NFC : KG111_04090 KG111_04095
PSIM : KR76_19860 KR76_19865
ACTU : Actkin_00167(glfT1)
BACT : AB656_03370 AB656_04870
TTS : Ththe16_0650 Ththe16_0885
TTL : TtJL18_1164 TtJL18_1423
TOS : Theos_0469 Theos_1547
MRE : K649_12430 K649_14430
SPIR : CWM47_12615 CWM47_36330
SOQ : LQ777_09715 LQ777_19075
» show all
Taxonomy
Reference
Authors
Mikusova K, Belanova M, Kordulakova J, Honda K, McNeil MR, Mahapatra S, Crick DC, Brennan PJ
Title
Identification of a novel galactosyl transferase involved in biosynthesis of the mycobacterial cell wall.
Journal
Sequence
Reference
Authors
Belanova M, Dianiskova P, Brennan PJ, Completo GC, Rose NL, Lowary TL, Mikusova K
Title
Galactosyl transferases in mycobacterial cell wall synthesis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.287