KEGG   ENZYME: 2.4.1.292
Entry
EC 2.4.1.292                Enzyme                                 
Name
GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase;
PglH
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol 4-alpha-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
3 UDP-N-acetyl-alpha-D-galactosamine + GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol = 3 UDP + [GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol
Product
UDP [CPD:C00015];
[GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol
Comment
Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway.
History
EC 2.4.1.292 created 2012
Orthology
K17249  GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase
Genes
CJECj1129c(pglH)
CJBBN148_1129c(pglH)
CJJCJJ81176_1146(pglH)
CJUC8J_1069(wlaC)
CJNICDCCJ07001_1086
CJICJSA_1071(pglH)
CJMCJM1_1107(capM)
CJSCJS3_1175(pglH)
CJPA911_05470
CJEJN564_01097
CJEUN565_01140
CJENN755_01133
CJEIN135_01166
CJERH730_06615
CJVMTVDSCj20_1132(pglH)
CJYQZ67_01207(pglH)
CJQUC78_1086(pglH)
CJLPJ17_05785
CJWPJ18_05600
CJRCJE1271(pglH)
CJDJJD26997_0592(pglH)
CJZM635_01350
CJXBN867_11200
CFFCFF8240_1385 CFF8240_1386
CFTCFF04554_1400(pglH) CFF04554_1401
CFVCFVI03293_1423(pglH) CFVI03293_1424
CFXCFV97608_1523(pglH) CFV97608_1524
CFZCSG_15220 CSG_15230
CAMPCFT03427_1348(pglH) CFT03427_1349
CFPCR44_06820 CR44_06825
CCVCCV52592_1215(pglH2) CCV52592_1216(pglH1)
CHACHAB381_0956 CHAB381_0958
CCOCCC13826_0454(pglH1) CCC13826_0455(pglH2)
CCOCCCON33237_1467(pglH1) CCON33237_1468(pglH2)
CLACLA_1251(pglH)
CLRUPTC16701_1234(pglH)
CLMUPTC16712_1252(pglH)
CLQUPTC4110_1236(pglH)
CLNUPTC3659_1471(pglH)
CLLCONCH_1202(pglH)
CCOLBN865_09990
CCCG157_03290
CCQN149_1070
CCFYSQ_03325
CCYYSS_06110
CCOIYSU_03360
CCOFVC76_05540(pglH_1)
CCOOATE51_01346(pglH)
CAJCIG1485E_1394(pglH) CIG1485E_1395
CISCINS_1216(pglH)
CVOCVOL_1230(pglH)
CPELCPEL_1357(pglH)
CAMRCAQ16704_1262(pglH)
CSMCSUB8521_1438(pglH)
CSFCSUB8523_1534(pglH)
CGRACGRAC_1492(pglH1) CGRAC_1494(pglH2)
CURECUREO_1377(pglH)
CHYOCHH_0374 CHH_0375(pglH)
CHVCHELV3228_0551(pglH)
CSPFCSF_0895(pglH1) CSF_0897(pglH2)
CPINCPIN18020_0859(pglH)
CCUNCCUN_1168(pglH)
CLXCLAN_0351 CLAN_0352(pglH)
CAVICAV_0408(pglH)
CHWA2J15_001335
CAMZCVIC12175_1313 CVIC12175_1314(pglH)
CAMYCSUIS_0196 CSUIS_0197(pglH)
COJCORN_1321(pglH)
CUXCUP3940_1140(pglH)
CRXCRECT_1679(pglH)
CGEOCGEO_1576(pglH1) CGEO_1578(pglH2)
CCORCCORG_0290(pglH)
CARMCARM_1284(pglH)
CMUCCMCT_0313(pglH1) CMCT_0314(pglH2)
CSHOCSHOW_1521(pglH)
CINFCINF_0320
CNVCNZW441b_1132(pglH)
CVUCVULP_0489(pglH)
 » show all
Reference
1  [PMID:16186480]
  Authors
Glover KJ, Weerapana E, Imperiali B
  Title
In vitro assembly of the undecaprenylpyrophosphate-linked heptasaccharide for prokaryotic N-linked glycosylation.
  Journal
Proc Natl Acad Sci U S A 102:14255-9 (2005)
DOI:10.1073/pnas.0507311102
  Sequence
[cje:Cj1129c]
Reference
2  [PMID:19159314]
  Authors
Troutman JM, Imperiali B
  Title
Campylobacter jejuni PglH is a single active site processive polymerase that utilizes product inhibition to limit sequential glycosyl transfer reactions.
  Journal
Biochemistry 48:2807-16 (2009)
DOI:10.1021/bi802284d
  Sequence
[cje:Cj1129c]
Reference
3  [PMID:21606362]
  Authors
Borud B, Viburiene R, Hartley MD, Paulsen BS, Egge-Jacobsen W, Imperiali B, Koomey M
  Title
Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system.
  Journal
Proc Natl Acad Sci U S A 108:9643-8 (2011)
DOI:10.1073/pnas.1103321108
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.292
IUBMB Enzyme Nomenclature: 2.4.1.292
ExPASy - ENZYME nomenclature database: 2.4.1.292
BRENDA, the Enzyme Database: 2.4.1.292

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