| Entry |
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| Name |
L-demethylnoviosyl transferase;
novM (gene name);
dTDP-beta-L-noviose:novobiocic acid 7-O-noviosyltransferase;
L-noviosyl transferase
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| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
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| Sysname |
dTDP-4-O-demethyl-beta-L-noviose:novobiocic acid 7-O-[4-O-demethyl-L-noviosyl]transferase
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| Reaction(IUBMB) |
dTDP-4-O-demethyl-beta-L-noviose + novobiocic acid = dTDP + demethyldecarbamoyl novobiocin [RN: R06770]
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| Reaction(KEGG) |
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| Substrate |
dTDP-4-O-demethyl-beta-L-noviose [CPD: C12481];
novobiocic acid [CPD: C12474]
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| Product |
dTDP [CPD: C00363];
demethyldecarbamoyl novobiocin
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| Comment |
The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic, novobiocin.
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| History |
EC 2.4.1.302 created 2013, modified 2016
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K12711 | L-demethylnoviosyl transferase |
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| Genes |
| SCYE: | R2B67_24655 R2B67_24840 |
| SPHW: | NFX46_24910(mtmGII) |
| SSPN: | LXH13_14010 LXH13_14045 |
| DVC: | Dvina_05705 Dvina_40140 |
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| Reference |
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| Authors |
Freel Meyers CL, Oberthur M, Anderson JW, Kahne D, Walsh CT |
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| Title |
Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Albermann C, Soriano A, Jiang J, Vollmer H, Biggins JB, Barton WA, Lesniak J, Nikolov DB, Thorson JS |
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| Title |
Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.4.1.302 |
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