Entry |
|
Name |
GDP-Fuc:beta-D-Gal-1,3-alpha-D-GalNAc-1,3-alpha-GalNAc-diphosphoundecaprenol alpha-1,2-fucosyltransferase;
WbnK
|
Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
|
Sysname |
GDP-beta-L-fucose:beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol alpha-1,2-fucosyltransferase
|
Reaction(IUBMB) |
GDP-beta-L-fucose + beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol [RN: R10439]
|
Reaction(KEGG) |
|
Substrate |
GDP-beta-L-fucose [CPD: C00325];
beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol [CPD: C20622]
|
Product |
GDP [CPD: C00035];
alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->3)-alpha-D-GalNAc-diphospho-ditrans,octacis-undecaprenol [CPD: C20625]
|
Comment |
The enzyme is involved in the biosynthesis of the O-polysaccharide repeating unit of the bacterium Escherichia coli serotype O86.
|
History |
EC 2.4.1.308 created 2013
|
Orthology |
K21367 | O86/O127-antigen biosynthesis alpha-1,2-fucosyltransferase |
|
Genes |
|
Reference |
|
Authors |
Yi W, Shao J, Zhu L, Li M, Singh M, Lu Y, Lin S, Li H, Ryu K, Shen J, Guo H, Yao Q, Bush CA, Wang PG |
Title |
Escherichia coli O86 O-antigen biosynthetic gene cluster and stepwise enzymatic synthesis of human blood group B antigen tetrasaccharide. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Woodward R, Yi W, Li L, Zhao G, Eguchi H, Sridhar PR, Guo H, Song JK, Motari E, Cai L, Kelleher P, Liu X, Han W, Zhang W, Ding Y, Li M, Wang PG |
Title |
In vitro bacterial polysaccharide biosynthesis: defining the functions of Wzy and Wzz. |
Journal |
|
Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.4.1.308 |
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