KEGG ENZYME: 2.4.1.310

ENZYME: 2.4.1.310

Entry

EC 2.4.1.310                Enzyme

Name

vancomycin aglycone glucosyltransferase;
GtfB (ambiguous)

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-glucose:vancomycin aglycone 48-O-beta-glucosyltransferase

Reaction(IUBMB)

UDP-alpha-D-glucose + vancomycin aglycone = UDP + devancosaminyl-vancomycin [RN:R10594]

Reaction(KEGG)

R10594

Substrate

UDP-alpha-D-glucose [CPD:C00029];
vancomycin aglycone [CPD:C20719]

Product

UDP [CPD:C00015];
devancosaminyl-vancomycin [CPD:C20720]

Comment

The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin.

History

EC 2.4.1.310 created 2013

Pathway

ec01055

Biosynthesis of vancomycin group antibiotics

Orthology

K16444

vancomycin aglycone glucosyltransferase

Genes

LGU:	LG3211_2060(gtfB)

LEZ:

GLE_1936

LEM:

LEN_3062

LYA:	RDV84_22435

BOI:	BLM15_03940

BVES:

QO058_03400

MIV:	C4E04_17165

MLD:	U0023_04240 U0023_24685

DNP:	N8A98_01710

CMB:	CSW64_17500

HNE:

HNE_2384

SPAP:

H3Z74_00855 H3Z74_10395

SUR:	STAUR_4277

AGE:	AA314_00618

CFUS:

CYFUS_000252

SCL:	sce8970(gtfE)

SCU:	SCE1572_48875

PAUU:

E8A73_008730

SAMY:

DB32_007987

ACEL:

acsn021_15630

MPA:

MAP_2871c

MAO:

MAP4_0937

MAVI:

RC58_04605

MAV:

MAV_3653

MIT:

OCO_25740

MIA:

OCU_25590

MID:

MIP_03577

MYO:

OEM_24180

MCHI:

AN480_13525

MIR:

OCQ_24300

MMAN:

MMAN_03190

MSA:	Mycsm_04809

MUL:

MUL_4949

MMI:

MMAR_0148

MMAE:

MMARE11_01350

MLI:	MULP_00133

MPSE:

MPSD_01460

MMM:

W7S_12435

MSHG:

MSG_01769

MFJ:	MFLOJ_14760

MSTO:

MSTO_16320

MSIM:

MSIM_05540

MLW:	MJO58_09610

MCOO:

MCOO_08500 MCOO_10290

MBAI:

MB901379_00113

MADI:

A7U43_08185

MNE:	D174_23150

MYN:	MyAD_22700

MRH:	MycrhN_1486 MycrhN_5442

MMOR:

MMOR_38890

MCEE:

MCEL_38310

NBR:	O3I_020415 O3I_022455

NSR:	NS506_05801(gtfB)

NWL:	NWFMUON74_19990 NWFMUON74_30120

NHU:	H0264_29045

NYA:	LTV02_04980

NSPU:

IFM12276_65010

NYU:	D7D52_23310

RHA:	RHA1_ro03522

ROA:	Pd630_LPD07907

ROZ:	CBI38_14410

SGRF:

SGFS_055550

SHY:

SHJG_1904

SHO:	SHJGH_1669

SRC:	M271_06890

SBH:

SBI_02990

SVE:

SVEN_3444

SALS:

SLNWT_2781 SLNWT_4757

STRE:

GZL_07987

SLC:	SL103_17190

SPRI:

SPRI_5993

SRW:	TUE45_pSRc_0432(TUE45_pSRTUE45c_0432)

SRN:	A4G23_03608

SALW:

CP975_15810

SGM:	GCM10017557_01070 GCM10017557_03400

SCAD:

DN051_04670

SLS:	SLINC_0863

SNR:	SNOUR_36265

SSIA:

A7J05_01405

SGV:	B1H19_02020

SALF:

SMD44_04791

SALJ:

SMD11_6659 SMD11_6727

SLX:	SLAV_16635(novM1) SLAV_35915(novM2)

SFK:	KY5_7970 KY5_7986

SGE:	DWG14_00394(aknK)

SLK:	SLUN_38755

SGD:	ELQ87_34360

SCYA:

EJ357_09080

SNQ:	CP978_01590

SKA:	CP970_42930

SFIC:

EIZ62_01765 EIZ62_14495

SAQU:

EJC51_30950 EJC51_40985

SBY:	H7H31_16795

SCOE:

CP976_19455

SBAT:

G4Z16_02265

SNF:	JYK04_00799(gtfB)

SPLA:

CP981_09155 CP981_33240

SATA:

C5746_37480

SLIA:

HA039_31000

SVD:	CP969_00880

SAUH:

SU9_005065

SFB:	CP974_19545

SMOB:

J7W19_11085

SPEU:

CGZ69_06345

SROI:

IAG44_03180 IAG44_35960

SMAO:

CAG99_18345

SGOB:

test1122_05295

SINE:

KI385_00245 KI385_04200 KI385_41035

SLF:	JEQ17_42820

SDEC:

L3078_24150

SCAE:

IHE65_21475

SCIR:

STRCI_007857

SXT:	KPP03845_101106(gtfB_1) KPP03845_200022(gtfB_1) KPP03845_200024(gtfB_2)

SLON:

LGI35_44440

SYUN:

MOV08_37090

SCYN:

N8I84_38305

SOV:	QZH56_28545

SFIY:

F0344_05285

SCOA:

QU709_41440

SROC:

RGF97_15680

SFP:	QUY26_17280

STRZ:

OYE22_16530

SCT:	SCAT_p1593(rgt)

SCY:	SCATT_p01310

KIT:	CFP65_7138

ABRY:

NYE86_16550 NYE86_34225

LMOI:

VV02_12065

MICG:

GJV80_02950

TFL:	RPIT_10355

KFL:

Kfla_0374

KQI:	F1D05_22545

KSL:	OG809_09240

TCU:

Tcur_2526

ACTW:

F7P10_15695

SRO:

Sros_5179

NOA:	BKM31_42295

NCX:	Nocox_13400(noc25)

NGN:	LCN96_07825

FRE:	Franean1_5814

SACG:

FDZ84_31065

AMD:	AMED_3957 AMED_5501

AMN:	RAM_20165 RAM_28035

AMM:	AMES_3910 AMES_5434

AMZ:	B737_3910 B737_5434

AOI:	AORI_1487 AORI_3038 AORI_6511

AJA:	AJAP_06410 AJAP_12965 AJAP_32080 AJAP_32090 AJAP_32095

AMQ:	AMETH_1868

AMYB:

BKN51_26020 BKN51_41465 BKN51_41470 BKN51_41480

AMYY:

YIM_26400(novM3)

AORI:

SD37_07860 SD37_26075 SD37_33685

APRT:

MUY14_06180 MUY14_42750

AROO:

NQK81_15450 NQK81_15460 NQK81_15465 NQK81_15470 NQK81_33260

AMI:

Amir_3897

SESP:

BN6_44490(gtuS1-3) BN6_68280(gtuS1-1)

SSYI:

EKG83_16745 EKG83_30910

KAL:	KALB_3316 KALB_7082

KUT:	JJ691_01380 JJ691_13220 JJ691_53170 JJ691_60960 JJ691_70450 JJ691_70460

KPHY:

AOZ06_14195 AOZ06_27475 AOZ06_46940 AOZ06_50140

LED:	BBK82_23920

ACTA:

C1701_00030

PMAD:

BAY61_20630

CROS:

N8J89_11445 N8J89_19165 N8J89_20500 N8J89_25045

UME:	RM788_07160 RM788_11880

MAU:	Micau_2443

MIL:

ML5_5919

MICB:

MicB006_3073

MCAB:

HXZ27_03580 HXZ27_05415

MCHL:

PVK74_10465

ASE:	ACPL_4499(gtfE)

AFS:

AFR_23425

ACTS:

ACWT_4370

ACTL:

L3i22_034990 L3i22_062710

AOU:	ACTOB_006483 ACTOB_006486 ACTOB_006487

DVC:	Dvina_39180

GLY:	K3N28_18315 K3N28_22670

ATQ:	GH723_03540 GH723_03545

TOQ:	HCG51_11195

VBH:	CMV30_01090

ROO:	G5S37_27010

VBA:	IMCC26134_08695

LUB:	TBR22_A01540

GBA:

J421_6182

PGIN:

FRZ67_17255

» show all

Reference

1 [PMID:11294642]

Authors

Losey HC, Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT

Title

Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.

Journal

Biochemistry 40:4745-55 (2001)
DOI:10.1021/bi010050w

Reference

2 [PMID:11470430]

Authors

Mulichak AM, Losey HC, Walsh CT, Garavito RM

Title

Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics.

Journal

Structure 9:547-57 (2001)
DOI:10.1016/S0969-2126(01)00616-5

Sequence

[ag:CAA11775]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.310

IUBMB Enzyme Nomenclature:

2.4.1.310

ExPASy - ENZYME nomenclature database:

2.4.1.310

BRENDA, the Enzyme Database:

2.4.1.310

DBGET integrated database retrieval system