| Entry |
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| Name |
chloroorienticin B synthase;
GtfA
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| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
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| Sysname |
dTDP-L-4-epi-vancosamine:desvancosaminyl-vancomycin vancosaminyltransferase
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| Reaction(IUBMB) |
dTDP-beta-L-4-epi-vancosamine + desvancosaminyl-vancomycin = dTDP + chloroorienticin B [RN: R10595]
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| Reaction(KEGG) |
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| Substrate |
dTDP-beta-L-4-epi-vancosamine [CPD: C12321];
desvancosaminyl-vancomycin [CPD: C20720]
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| Product |
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| Comment |
The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin.
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| History |
EC 2.4.1.311 created 2013
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| Pathway |
| ec01055 | Biosynthesis of vancomycin group antibiotics |
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| Orthology |
| K16440 | chloroorienticin B synthase |
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| Genes |
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| Reference |
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| Authors |
Mulichak AM, Losey HC, Lu W, Wawrzak Z, Walsh CT, Garavito RM |
|---|
| Title |
Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway. |
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| Journal |
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| Sequence |
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| Reference |
|
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| Authors |
Lu W, Oberthur M, Leimkuhler C, Tao J, Kahne D, Walsh CT |
|---|
| Title |
Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.4.1.311 |
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