Entry |
|
Name |
chloroorienticin B synthase;
GtfA
|
Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
|
Sysname |
dTDP-L-4-epi-vancosamine:desvancosaminyl-vancomycin vancosaminyltransferase
|
Reaction(IUBMB) |
dTDP-beta-L-4-epi-vancosamine + desvancosaminyl-vancomycin = dTDP + chloroorienticin B [RN: R10595]
|
Reaction(KEGG) |
|
Substrate |
dTDP-beta-L-4-epi-vancosamine [CPD: C12321];
desvancosaminyl-vancomycin [CPD: C20720]
|
Product |
|
Comment |
The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin.
|
History |
EC 2.4.1.311 created 2013
|
Pathway |
ec01055 | Biosynthesis of vancomycin group antibiotics |
|
Orthology |
K16440 | chloroorienticin B synthase |
|
Genes |
|
Reference |
|
Authors |
Mulichak AM, Losey HC, Lu W, Wawrzak Z, Walsh CT, Garavito RM |
Title |
Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Lu W, Oberthur M, Leimkuhler C, Tao J, Kahne D, Walsh CT |
Title |
Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin. |
Journal |
|
Sequence |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 2.4.1.311 |
|