KEGG ENZYME: 2.4.1.313

ENZYME: 2.4.1.313

Entry

EC 2.4.1.313                Enzyme

Name

protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase;
B3GALNT2

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl-threonyl-[protein] 3-beta-N-acetyl-D-galactosaminyltransferase

Reaction(IUBMB)

UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] = UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [RN:R10620 R12292]

Reaction(KEGG)

R10620 R12292(G);
(other) R07614(G)

Substrate

UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [CPD:C20723]

Product

UDP [CPD:C00015];
3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] [CPD:C20734]

Comment

The human protein is specific for UDP-N-acetyl-alpha-D-galactosamine as donor [1]. The enzyme is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.

History

EC 2.4.1.313 created 2013

Pathway

ec00515

Mannose type O-glycan biosynthesis

ec01100

Metabolic pathways

Orthology

K09654

beta-1,3-N-acetylgalactosaminyltransferase 2

Genes

HSA:	148789(B3GALNT2)

PTR:	469715(B3GALNT2)

PPS:	100978307(B3GALNT2)

GGO:	101140966(B3GALNT2)

PON:	100443319(B3GALNT2)

NLE:	100589286(B3GALNT2)

HMH:	116457320(B3GALNT2)

MCC:	711550(B3GALNT2)

MCF:	102146449(B3GALNT2)

MTHB:

126942458

MNI:	105474603(B3GALNT2)

CSAB:

103230797(B3GALNT2)

CATY:

105574887(B3GALNT2)

PANU:

101022522(B3GALNT2)

TGE:	112609098(B3GALNT2)

MLEU:

105546243(B3GALNT2)

RRO:	104679172(B3GALNT2)

RBB:	108522205(B3GALNT2)

TFN:	117076612(B3GALNT2)

PTEH:

111545245(B3GALNT2)

CANG:

105507317(B3GALNT2)

CJC:	100413278(B3GALNT2)

SBQ:	101046032(B3GALNT2)

CIMI:

108302833(B3GALNT2)

CSYR:

103254834(B3GALNT2)

MMUR:

105856483(B3GALNT2)

LCAT:

123627583(B3GALNT2)

PCOQ:

105823183(B3GALNT2)

OGA:	100966703(B3GALNT2)

MMU:	97884(B3galnt2)

MCAL:

110307761(B3galnt2)

MPAH:

110333891(B3galnt2)

RNO:	291212(B3galnt2)

MCOC:

116082779(B3galnt2)

ANU:	117713634(B3galnt2)

MUN:	110558133(B3galnt2)

CGE:	100768564(B3galnt2)

MAUA:

101830509(B3galnt2)

PROB:

127229762(B3galnt2)

PLEU:

114685249(B3galnt2)

MORG:

121432584 121432590

MFOT:

126501665

AAMP:

119817973(B3galnt2)

NGI:	103745134(B3galnt2)

HGL:	101697517(B3galnt2)

CPOC:

100727876(B3galnt2)

CCAN:

109692618(B3galnt2)

DORD:

105984384(B3galnt2)

DSP:	122113255(B3galnt2)

PLOP:

125367106(B3galnt2)

NCAR:

124961702

MMMA:

107157955(B3galnt2)

OCU:

100352278

TUP:	102477401(B3GALNT2)

GVR:	103605404(B3GALNT2) 103610581

CFA:	479196(B3GALNT2)

CLUD:

112660892(B3GALNT2)

VVP:	112927402(B3GALNT2)

VLG:	121488125(B3GALNT2)

NPO:	129499160(B3GALNT2)

AML:	100484405(B3GALNT2)

UMR:	103661896(B3GALNT2)

UAH:	113259001(B3GALNT2)

UAR:	123783134(B3GALNT2)

ELK:

111160534

LLV:

125084294

MPUF:

101690844(B3GALNT2)

MNP:	132016149(B3GALNT2)

MLK:	131829053(B3GALNT2)

NVS:	122900574(B3GALNT2)

ORO:	101372831(B3GALNT2)

EJU:	114210241(B3GALNT2)

ZCA:	113919984(B3GALNT2)

MLX:	118012931(B3GALNT2)

NSU:	110586017(B3GALNT2)

LWW:	102747812(B3GALNT2)

FCA:	101085750(B3GALNT2)

PYU:	121023154(B3GALNT2)

PCOO:

112851523(B3GALNT2)

PBG:	122492711(B3GALNT2)

LRUF:

124518623

PTG:	102961022(B3GALNT2)

PPAD:

109248879(B3GALNT2)

PUC:

125932585

AJU:

106982543

HHV:	120241810(B3GALNT2)

BTA:	100125310(B3GALNT2)

BOM:	102280720(B3GALNT2)

BIU:	109553768(B3GALNT2)

BBUB:

102403318(B3GALNT2)

BBIS:

105003121(B3GALNT2)

CHX:	102178329(B3GALNT2)

OAS:	101116957(B3GALNT2)

BTAX:

128047316(B3GALNT2)

ODA:	120860495 120865421 120882502

CCAD:

122446618(B3GALNT2)

MBEZ:

129555858(B3GALNT2)

SSC:	100620910(B3GALNT2)

CFR:	102506122(B3GALNT2) 102522922

CBAI:

105075110(B3GALNT2)

CDK:

116147114

VPC:	102526503(B3GALNT2)

BACU:

103018636(B3GALNT2)

LVE:	103083400(B3GALNT2)

OOR:	101271023(B3GALNT2)

DLE:	111163939(B3GALNT2)

PCAD:

102976716(B3GALNT2)

PSIU:

116741479(B3GALNT2)

NASI:

112410732(B3GALNT2)

ECB:	100058647(B3GALNT2)

EPZ:	103547683(B3GALNT2)

EAI:	106834710(B3GALNT2)

MYB:	102240384(B3GALNT2)

MYD:	102762905(B3GALNT2)

MMYO:

118649761 118678743(B3GALNT2)

MLF:	102422746(B3GALNT2)

PKL:	118727687(B3GALNT2)

EFUS:

103293437(B3GALNT2)

MNA:	107527201(B3GALNT2)

DRO:	112306100(B3GALNT2)

SHON:

118980670(B3GALNT2)

AJM:	119044225(B3GALNT2)

PDIC:

114512317(B3GALNT2)

PHAS:

123832228(B3GALNT2)

MMF:	118640731(B3GALNT2)

PPAM:

129072097(B3GALNT2)

HAI:	109387715(B3GALNT2)

RFQ:	117018531(B3GALNT2)

PALE:

102897229(B3GALNT2)

PGIG:

120592623(B3GALNT2)

PVP:	105302726(B3GALNT2)

RAY:	107520055(B3GALNT2)

MJV:	108401878(B3GALNT2)

TOD:	119244585(B3GALNT2)

SARA:

101546071(B3GALNT2)

LAV:	100663890(B3GALNT2)

TMU:

101358044

ETF:	101643748(B3GALNT2)

DNM:	101426827(B3GALNT2)

MDO:	100617587(B3GALNT2)

GAS:	123247102(B3GALNT2)

SHR:	100921524(B3GALNT2)

AFZ:

127559638

PCW:	110217849(B3GALNT2)

OAA:	100081648(B3GALNT2)

GGA:	430770(B3GALNT2)

PCOC:

116228320(B3GALNT2)

MGP:	100538415(B3GALNT2)

CJO:	107311372(B3GALNT2)

TPAI:

128075254(B3GALNT2)

LMUT:

125690206(B3GALNT2)

NMEL:

110396188(B3GALNT2)

APLA:

101803248(B3GALNT2)

ACYG:

106048080(B3GALNT2)

CATA:

118252870(B3GALNT2)

AFUL:

116487155(B3GALNT2)

TGU:	100218422(B3GALNT2)

LSR:	110468868(B3GALNT2)

SCAN:

103818567(B3GALNT2)

PMOA:

120501152(B3GALNT2)

OTC:	121340901(B3GALNT2)

PRUF:

121363278(B3GALNT2)

GFR:	102040498(B3GALNT2)

FAB:	101813810(B3GALNT2)

OMA:	130251521(B3GALNT2)

PHI:	102113102(B3GALNT2)

PMAJ:

107201263(B3GALNT2)

CCAE:

111927067(B3GALNT2)

CCW:	104684442(B3GALNT2)

CBRC:

103624154(B3GALNT2)

ETL:	114066550(B3GALNT2)

ZAB:	102071174(B3GALNT2)

ACHL:

103809677(B3GALNT2)

SVG:	106852280(B3GALNT2)

MMEA:

130588785(B3GALNT2)

HRT:	120749798(B3GALNT2)

FPG:	101914116(B3GALNT2)

FCH:	102053282(B3GALNT2)

CLV:	102094245(B3GALNT2)

EGZ:	104131046(B3GALNT2)

NNI:	104019876(B3GALNT2)

PCRI:

104025223(B3GALNT2)

PLET:

104624995(B3GALNT2)

EHS:	104511637(B3GALNT2)

PCAO:

104044079(B3GALNT2)

ACUN:

113477903(B3GALNT2)

TALA:

104360176(B3GALNT2)

PADL:

103921275(B3GALNT2)

AFOR:

103901030(B3GALNT2)

ACHC:

115349793(B3GALNT2)

HALD:

104318455(B3GALNT2)

HLE:	104828736(B3GALNT2)

AGEN:

126051826

GCL:

127014754

CCRI:

104167311(B3GALNT2)

CSTI:

104556915(B3GALNT2)

CMAC:

104477116(B3GALNT2)

BREG:

104641412(B3GALNT2)

FGA:	104073654(B3GALNT2)

GSTE:

104257807(B3GALNT2)

LDI:	104344542(B3GALNT2)

MNB:	103773127(B3GALNT2)

OHA:	104328303(B3GALNT2)

NNT:	104405655(B3GALNT2)

SHAB:

115613553(B3GALNT2)

DPUB:

104306642(B3GALNT2)

PGUU:

104458601(B3GALNT2)

CPEA:

104388703(B3GALNT2)

AVIT:

104268702

CVF:	104287259(B3GALNT2)

RTD:	128907332(B3GALNT2)

CUCA:

104060370(B3GALNT2)

TEO:	104383309(B3GALNT2)

AAM:	106486759(B3GALNT2)

AROW:

112964560(B3GALNT2)

NPD:	112951944(B3GALNT2)

TGT:	104573820(B3GALNT2)

DNE:	112989001(B3GALNT2)

SCAM:

104148168(B3GALNT2)

ASN:	102378749(B3GALNT2)

AMJ:	102570410(B3GALNT2)

CPOO:

109319102(B3GALNT2)

GGN:	109304241(B3GALNT2)

PSS:	102458995(B3GALNT2)

CMY:	102938135(B3GALNT2)

CCAY:

125633878(B3GALNT2)

DCC:	119853181(B3GALNT2)

CPIC:

101933681(B3GALNT2)

TST:	117874692(B3GALNT2)

CABI:

116826427(B3GALNT2)

MRV:	120401460(B3GALNT2)

ACS:	100557470(b3galnt2)

ASAO:

132761198(B3GALNT2)

PVT:	110075614(B3GALNT2)

SUND:

121926050(B3GALNT2)

PBI:	103057702(B3GALNT2)

PMUR:

107288312(B3GALNT2)

CTIG:

120312350(B3GALNT2)

TSR:	106538193(B3GALNT2)

PGUT:

117671974(B3GALNT2)

APRI:

131189743(B3GALNT2)

PTEX:

113439370(B3GALNT2)

NSS:	113413222(B3GALNT2)

VKO:	123018214(B3GALNT2)

PMUA:

114594411(B3GALNT2)

PRAF:

128410836(B3GALNT2)

ZVI:	118081866(B3GALNT2)

HCG:	128346454(B3GALNT2)

GJA:	107117761(B3GALNT2)

STOW:

125426945(B3GALNT2)

EMC:	129343827(B3GALNT2)

XLA:	431874(b3galnt2.L)

XTR:	496641(b3galnt2)

NPR:	108802270(B3GALNT2)

RTEM:

120924684(B3GALNT2)

BBUF:

120991231(B3GALNT2)

BGAR:

122937988(B3GALNT2)

MUO:	115466710(B3GALNT2)

GSH:	117356686(B3GALNT2)

DRE:	553716(b3galnt2)

SRX:	107728324 107730378

SANH:

107667096 107691207(b3galnt2)

SGH:	107557719(b3galnt2)

CAUA:

113056633(b3galnt2)

CGIB:

127970406

PTET:

122357050(b3galnt2)

LROH:

127175507(b3galnt2)

OMC:	131551766(b3galnt2)

PPRM:

120461138(b3galnt2)

RKG:	130068994(b3galnt2)

MAMB:

125276472(b3galnt2)

CIDE:

127525478

MASI:

127411945

TROS:

130559120(b3galnt2)

TDW:	130431570(b3galnt2)

MANU:

129415478(b3galnt2)

IPU:

108263411

IFU:	128605351(b3galnt2)

PHYP:

113541960(b3galnt2)

SMEO:

124376785(b3galnt2)

TFD:	113645019(b3galnt2)

TVC:	132847068(b3galnt2)

AMEX:

103030528(b3galnt2)

CMAO:

118810721(b3galnt2)

EEE:	113577753(b3galnt2)

CHAR:

105902284(b3galnt2)

TRU:	101071098 105419396

TFS:	130534000(b3galnt2)

TNG:	GSTEN00030871G001

LCO:	104934548(b3galnt2)

NCC:	104960299(b3galnt2)

TBEN:

117499420(b3galnt2)

CGOB:

115020522(b3galnt2)

PGEO:

117459743(b3galnt2)

GACU:

117553497(b3galnt2)

EMAC:

134858350(b3galnt2)

ELY:	117247938(b3galnt2)

EFO:	125903367(b3galnt2)

PLEP:

121954705(b3galnt2)

SLUC:

116051160(b3galnt2)

ECRA:

117960477(b3galnt2)

ESP:	116705436(b3galnt2)

PFLV:

114572511(b3galnt2)

GAT:	120820346(b3galnt2)

PPUG:

119214534(b3galnt2)

AFB:	129092434(b3galnt2)

CLUM:

117744227(b3galnt2)

PSWI:

130207041(b3galnt2)

MSAM:

119917470(b3galnt2)

SCHU:

122884526(b3galnt2)

CUD:	121510883(b3galnt2)

ALAT:

119034186(b3galnt2)

MZE:	101477300(b3galnt2)

ONL:	100693767(b3galnt2)

OAU:	116318511(b3galnt2)

OLA:	101169879(b3galnt2)

OML:	112162201(b3galnt2)

CSAI:

133464171(b3galnt2)

XMA:	102234069(b3galnt2)

XCO:	114138582(b3galnt2)

XHE:	116713769(b3galnt2)

PRET:

103477261(b3galnt2)

PFOR:

103137691(b3galnt2)

PLAI:

106949762(b3galnt2)

PMEI:

106930335(b3galnt2)

GAF:	122842964(b3galnt2)

PPRL:

129360157(b3galnt2)

CVG:	107087799(b3galnt2)

CTUL:

119782941(b3galnt2)

GMU:	124859564(b3galnt2)

NFU:	107375431(b3galnt2)

KMR:	108240630(b3galnt2)

ALIM:

106515875(b3galnt2)

NWH:	119424188(b3galnt2)

AOCE:

111573739(b3galnt2)

MCEP:

125019231(b3galnt2)

CSEM:

103387616(b3galnt2)

POV:	109642026(b3galnt2)

SSEN:

122782189(b3galnt2)

HHIP:

117775784(b3galnt2)

HSP:	118119400(b3galnt2)

SMAU:

118284051(b3galnt2)

LCF:

108885798

SDU:	111220668(b3galnt2)

SLAL:

111659007(b3galnt2)

XGL:	120796886(b3galnt2)

HCQ:	109516187(b3galnt2)

SSCV:

125978963

SBIA:

133510188(b3galnt2)

PEE:	133409992(b3galnt2)

PTAO:

133485829(b3galnt2)

BPEC:

110157249(b3galnt2)

MALB:

109962360(b3galnt2)

BSPL:

114842028(b3galnt2)

SJO:	128372802(b3galnt2)

SASA:

106578767(b3galnt2)

STRU:

115155376(b3galnt2)

OTW:	112237453(b3galnt2)

OMY:	110491207(b3galnt2)

OGO:	124048033(b3galnt2)

OKI:	109866006(b3galnt2)

OKE:	127915928(b3galnt2) 127922397

SALP:

112071951(b3galnt2)

SNH:	120046044(b3galnt2)

CCLU:

121580569(b3galnt2)

ELS:	105006091(b3galnt2)

SFM:	108926991 108933762(b3galnt2)

PKI:	111835667 111856374(b3galnt2)

AANG:

118218459(b3galnt2)

LOC:	102691105(b3galnt2)

PSPA:

121316077 121317203

ARUT:

117402669 117410811(b3galnt2)

PSEX:

120516292(b3galnt2)

LCM:	102359133(B3GALNT2)

CMK:	103178875(b3galnt2)

CPLA:

122542298(b3galnt2)

HOC:	132833954(b3galnt2)

LERI:

129696994(b3galnt2)

PMRN:

116948304(B3GALNT2)

LRJ:	133352658(B3GALNT2)

BFO:

118425673

BBEL:

109472289

CIN:

100184607

SCLV:

120326995

SPU:

100893207

LPIC:

129265085

APLC:

110978840

SKO:

100372327

BTAB:

109031387

CLEC:

106672465

HHAL:

106689487

NLU:

111058580

HVI:

124356624

MQU:	128986638 128987088

PHU:	Phum_PHUM612020

TPAL:

117654182

ZNE:

110828299

CSEC:

111869785

IEL:

124157001

PVM:

113806206

PJA:

122265206

PCHN:

125025680

PMOO:

119578963

HAME:

121872679

PCLA:

123759295

PTRU:

123504780

ESN:

126996469

LSM:

121125872

TCF:

131877588

PPOI:

119107034

DSV:

119449330

RSAN:

119382341

RMP:

119178637

VDE:

111244927

VJA:

111268042

TUT:

107363544

DPTE:

113790809

CSCU:

111636005

PTEP:

107441986

ABRU:

129984035

UDV:	129223830 129224822

SDM:

118192090

LPOL:

106465238

HRO:	HELRODRAFT_154688

PVUL:

126829342

PCAN:

112570564

BGT:

106068129

GAE:

121371645

CRG:

105332774

CVN:

111133674

CANU:

128180828

OED:

125659768

MYI:

110454356

PMAX:

117324411

MMER:

123546429

DPOL:

127843112

OBI:

106876718

NVE:

5507055

EPA:

110233214

ATEN:

116303868

ADF:

107345723

AMIL:

114965109

PDAM:

113667536

SPIS:

111330956

DGT:

114516906

XEN:	124437811 124441626 124441633 124443248 124445906 124456397 124456398 124459024 124459042

HMG:

100200949

HSY:

130614808

TAD:	TRIADDRAFT_52586

SRE:	PTSG_06143

» show all

Reference

1 [PMID:14724282]

Authors

Hiruma T, Togayachi A, Okamura K, Sato T, Kikuchi N, Kwon YD, Nakamura A, Fujimura K, Gotoh M, Tachibana K, Ishizuka Y, Noce T, Nakanishi H, Narimatsu H

Title

A novel human beta1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAcbeta1-3GlcNAc.

Journal

J Biol Chem 279:14087-95 (2004)
DOI:10.1074/jbc.M310614200

Sequence

[hsa:148789]

Reference

2 [PMID:23929950]

Authors

Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP

Title

SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.