Entry Name tylactone mycaminosyltransferase;
Class Transferases;BRITE hierarchy
Sysname dTDP-alpha-D-mycaminose:tylactone 5-O-beta-D-mycaminosyltransferase
Reaction(IUBMB) tylactone + dTDP-alpha-D-mycaminose = dTDP + 5-O-beta-D-mycaminosyltylactone [RN:
R06450 ]
Reaction(KEGG) Substrate tylactone [CPD:
C12000 ];
dTDP-alpha-D-mycaminose [CPD:
C11933 ]
Product dTDP [CPD:
C00363 ];
5-O-beta-D-mycaminosyltylactone [CPD:
C12001 ]
Comment The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. Activity is significantly enhanced by the presence of an accessory protein encoded by the tylM3 gene.
History EC 2.4.1.316 created 2014
Pathway ec00522 Biosynthesis of 12-, 14- and 16-membered macrolides
ec01110 Biosynthesis of secondary metabolites
Orthology K15989 tylactone mycaminosyltransferase
Reference Authors Gandecha AR, Large SL, Cundliffe E
Title Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome.
Journal Sequence Reference Authors Melancon CE 3rd, Takahashi H, Liu HW
Title Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.4.1.316
