KEGG ENZYME: 2.4.1.318

ENZYME: 2.4.1.318

Entry

EC 2.4.1.318                Enzyme

Name

demethyllactenocin mycarosyltransferase;
tylCV (gene name);
tylC5 (gene name)

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

dTDP-beta-L-mycarose:demethyllactenocin 4'-O-alpha-L-mycarosyltransferase

Reaction(IUBMB)

dTDP-beta-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin [RN:R06452]

Reaction(KEGG)

R06452

Substrate

dTDP-beta-L-mycarose [CPD:C11916];
demethyllactenocin [CPD:C12003]

Product

dTDP [CPD:C00363];
demethylmacrocin [CPD:C02400]

Comment

The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.

History

EC 2.4.1.318 created 2014

Pathway

ec00522

Biosynthesis of 12-, 14- and 16-membered macrolides

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K15994

demethyllactenocin mycarosyltransferase

Reference

1 [PMID:10658660]

Authors

Bate N, Butler AR, Smith IP, Cundliffe E

Title

The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.

Journal

Microbiology 146 ( Pt 1):139-46 (2000)
DOI:10.1099/00221287-146-1-139

Sequence

[ag:AAD41824]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.318

IUBMB Enzyme Nomenclature:

2.4.1.318

ExPASy - ENZYME nomenclature database:

2.4.1.318

BRENDA, the Enzyme Database:

2.4.1.318

DBGET integrated database retrieval system