| Entry |
|
|---|
| Name |
devancosaminyl-vancomycin vancosaminetransferase;
devancosaminyl-vancomycin TDP-vancosaminyltransferase;
GtfD;
dTDP-beta-L-vancomycin:desvancosaminyl-vancomycin beta-L-vancosaminetransferase;
desvancosaminyl-vancomycin vancosaminetransferase
|
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
|
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| Sysname |
dTDP-beta-L-vancomycin:devancosaminyl-vancomycin beta-L-vancosaminetransferase
|
|---|
| Reaction(IUBMB) |
dTDP-beta-L-vancosamine + devancosaminyl-vancomycin = dTDP + vancomycin [RN: R10833]
|
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| Reaction(KEGG) |
|
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| Substrate |
dTDP-beta-L-vancosamine [CPD: C12322];
devancosaminyl-vancomycin [CPD: C20720]
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| Product |
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|---|
| Comment |
The enzyme, isolated from the bacterium Amycolatopsis orientalis, catalyses the ultimate step in the biosynthesis of the antibiotic vancomycin.
|
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| History |
EC 2.4.1.322 created 2014
|
|---|
| Pathway |
| ec01055 | Biosynthesis of vancomycin group antibiotics |
|
|---|
| Orthology |
| K16443 | desvancosaminyl-vancomycin vancosaminetransferase |
|
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| Genes |
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|---|
| Reference |
|
|---|
| Authors |
Losey HC, Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT |
|---|
| Title |
Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides. |
|---|
| Journal |
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|---|
| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
Mulichak AM, Lu W, Losey HC, Walsh CT, Garavito RM |
|---|
| Title |
Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands. |
|---|
| Journal |
|
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.4.1.322 |
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