Entry
Name
dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase;
AglC;
UDP-Glc-2,3-diNAcA glycosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate:dolichyl N-acetyl-alpha-D-glucosaminyl-phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase
Reaction(IUBMB)
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate + an archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate = UDP + an archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy-beta-D-glucuronsyl)-N-acetyl-alpha-D-glucosaminyl phosphate [RN:
R11224 ]
Reaction(KEGG)
Substrate
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [CPD:
C19725 ];
archaeal dolichyl N-acetyl-alpha-D-glucosaminyl phosphate [CPD:
C04678 ]
Product
UDP [CPD:
C00015 ];
archaeal dolichyl 3-O-(2,3-diacetamido-2,3-dideoxy-beta-D-glucuronsyl)-N-acetyl-alpha-D-glucosaminyl phosphate [CPD:
C21213 ]
Comment
The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, participates in the N-glycosylation of proteins. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60), it is alpha,omega-saturated and it may have additional unsaturated positions in the chain.
History
EC 2.4.1.335 created 2015
Orthology
K21305 dolichyl N-acetyl-alpha-D-glucosaminyl phosphate 3-beta-D-2,3-diacetamido-2,3-dideoxy-beta-D-glucuronosyltransferase
Genes
Taxonomy
Reference
Authors
Larkin A, Chang MM, Whitworth GE, Imperiali B
Title
Biochemical evidence for an alternate pathway in N-linked glycoprotein biosynthesis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.335