KEGG ENZYME: 2.4.1.338

ENZYME: 2.4.1.338

Entry

EC 2.4.1.338                Enzyme

Name

validoxylamine A glucosyltransferase;
vldK (gene name);
valG (gene name)

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-glucose:validoxylamine-A 4'-O-glucosyltransferase

Reaction(IUBMB)

UDP-alpha-D-glucose + validoxylamine A = UDP + validamycin A [RN:R11241]

Reaction(KEGG)

R11241

Substrate

UDP-alpha-D-glucose [CPD:C00029];
validoxylamine A [CPD:C17700]

Product

UDP [CPD:C00015];
validamycin A [CPD:C12112]

Comment

The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, catalyses the ultimate step in the biosynthesis of the antifungal agent validamycin A.

History

EC 2.4.1.338 created 2016

Pathway

ec00525

Acarbose and validamycin biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K20438

validoxylamine A glucosyltransferase

Genes

SHY:

SHJG_0282

SHO:	SHJGH_0116

SNQ:	CP978_00035

Reference

1 [PMID:16632251]

Authors

Bai L, Li L, Xu H, Minagawa K, Yu Y, Zhang Y, Zhou X, Floss HG, Mahmud T, Deng Z

Title

Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A.

Journal

Chem Biol 13:387-97 (2006)
DOI:10.1016/j.chembiol.2006.02.002

Sequence

[shy:SHJG_0282]

Reference

2 [PMID:18563934]

Authors

Xu H, Minagawa K, Bai L, Deng Z, Mahmud T

Title

Catalytic analysis of the validamycin glycosyltransferase (ValG) and enzymatic production of 4''-epi-validamycin A.

Journal

J Nat Prod 71:1233-6 (2008)
DOI:10.1021/np800185k

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.338

IUBMB Enzyme Nomenclature:

2.4.1.338

ExPASy - ENZYME nomenclature database:

2.4.1.338

BRENDA, the Enzyme Database:

2.4.1.338

DBGET integrated database retrieval system