KEGG   ENZYME: 2.4.1.343
Entry
EC 2.4.1.343                Enzyme                                 
Name
UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol alpha-1,3-galactosyltransferase;
wclR (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-galactosyltransferase (configuration-retaining)
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + alpha-D-Gal-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol [RN:R11599]
Reaction(KEGG)
R11599
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C01289]
Product
UDP [CPD:C00015];
alpha-D-Gal-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol [CPD:C21493]
Comment
The enzyme is involved in the the biosynthesis of the O-antigen repeating unit of Escherichia coli O3. Requires a divalent metal ion (Mn2+, Mg2+ or Fe2+). cf. EC 2.4.1.303, UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase.
History
EC 2.4.1.343 created 2017
Orthology
K24654  O3-antigen biosynthesis alpha-1,3-galactosyltransferase
Reference
1  [PMID:27196310]
  Authors
Chen C, Liu B, Xu Y, Utkina N, Zhou D, Danilov L, Torgov V, Veselovsky V, Feng L
  Title
Biochemical characterization of the novel alpha-1, 3-galactosyltransferase WclR from Escherichia coli O3.
  Journal
Carbohydr Res 430:36-43 (2016)
DOI:10.1016/j.carres.2016.04.012
  Sequence
[ag:ACH97149]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.343
IUBMB Enzyme Nomenclature: 2.4.1.343
ExPASy - ENZYME nomenclature database: 2.4.1.343
BRENDA, the Enzyme Database: 2.4.1.343

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (3)   
   InterPro (3)   
All databases (12)   

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