KEGG   ENZYME: 2.4.1.348
Entry
EC 2.4.1.348                Enzyme                                 
Name
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase;
WbdC
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
GDP-alpha-D-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = GDP + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11937]
Reaction(KEGG)
R11937
Substrate
GDP-alpha-D-mannose [CPD:C00096];
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C01289]
Product
GDP [CPD:C00035];
alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21780]
Comment
The enzyme is involved in the biosynthesis of the linker region of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotypes O8, O9 and O9a.
History
EC 2.4.1.348 created 2017
Orthology
K12995  O-antigen biosynthesis alpha-1,3-mannosyltransferase
Genes
ECX: EcHS_A2166
ECR: ECIAI1_2097(wbdC)
SBG: SBG_0618(wbdC)
SBZ: A464_691
SBV: N643_03115
KPJ: N559_1774
KVA: Kvar_1572
KPE: KPK_1682
KVD: KR75_26270
KVQ: SP68_06415
KQU: AVR78_21660
KLW: DA718_09860
PGE: LG71_13045
TCI: A7K98_13140
 » show all
Reference
1  [PMID:22875852]
  Authors
Greenfield LK, Richards MR, Li J, Wakarchuk WW, Lowary TL, Whitfield C
  Title
Biosynthesis of the polymannose lipopolysaccharide O-antigens from Escherichia coli serotypes O8 and O9a requires a unique combination of single- and multiple-active site mannosyltransferases.
  Journal
J Biol Chem 287:35078-91 (2012)
DOI:10.1074/jbc.M112.401000
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.348
IUBMB Enzyme Nomenclature: 2.4.1.348
ExPASy - ENZYME nomenclature database: 2.4.1.348
BRENDA, the Enzyme Database: 2.4.1.348

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (615)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (14)   
   RefGene (600)   
Protein sequence (6)   
   UniProt (4)   
   SWISS-PROT (2)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
Protein domain (3)   
   InterPro (3)   
All databases (634)   

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