KEGG   ENZYME: 2.4.1.349
Entry
EC 2.4.1.349                Enzyme                                 
Name
mannosyl-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase;
WbdB
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
2 GDP-alpha-D-mannose + alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = 2 GDP + alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11938]
Reaction(KEGG)
R11938
Substrate
GDP-alpha-D-mannose [CPD:C00096];
alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21780]
Product
GDP [CPD:C00035];
alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-alpha-D-mannosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21781]
Comment
The enzyme is involved in the biosynthesis of the linker region of the polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotypes O8, O9 and O9a. It has no activity with N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol (cf. EC 2.4.1.348, N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase).
History
EC 2.4.1.349 created 2017
Orthology
K12994  O-antigen biosynthesis alpha-1,3-mannosyltransferase
Genes
ECXEcHS_A2167(mtfB)
ECRECIAI1_2098(wbdB)
SBGSBG_0617(wbdB)
SBZA464_690
SBVN643_03110
KPJN559_1773
KVAKvar_1571
KPEKPK_1681
KVDKR75_26275
KVQSP68_06420
KQUAVR78_21665
EARCCG29191
KLWDA718_09855
PGELG71_13040
TCIA7K98_13145
 » show all
Reference
1  [PMID:22875852]
  Authors
Greenfield LK, Richards MR, Li J, Wakarchuk WW, Lowary TL, Whitfield C
  Title
Biosynthesis of the polymannose lipopolysaccharide O-antigens from Escherichia coli serotypes O8 and O9a requires a unique combination of single- and multiple-active site mannosyltransferases.
  Journal
J Biol Chem 287:35078-91 (2012)
DOI:10.1074/jbc.M112.401000
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.349
IUBMB Enzyme Nomenclature: 2.4.1.349
ExPASy - ENZYME nomenclature database: 2.4.1.349
BRENDA, the Enzyme Database: 2.4.1.349

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