KEGG ENZYME: 2.4.1.355

ENZYME: 2.4.1.355

Entry

EC 2.4.1.355                Enzyme

Name

poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase;
TarS

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-N-acetyl-alpha-D-glucosamine:4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)

Reaction(IUBMB)

n UDP-N-acetyl-alpha-D-glucosamine + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-(2-N-acetyl-beta-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R12014 R12872]

Reaction(KEGG)

R12014 R12872(G);
(other) R12316(G)

Substrate

UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21508]

Product

UDP [CPD:C00015];
4-O-(2-N-acetyl-beta-D-glucosaminyl-D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21849]

Comment

Involved in the biosynthesis of poly(ribitol-phosphate) teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds an N-acetyl-beta-D-glucosamine to the OH group at the 2 position of the ribitol phosphate units. cf. EC 2.4.1.70 [poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase].

History

EC 2.4.1.355 created 2018

Pathway

ec00552

Teichoic acid biosynthesis

Orthology

K22708

poly(ribitol-phosphate) beta-N-acetylglucosaminyltransferase

Genes

CIE:	AN232_28805

ASI:	ASU2_10100

ASS:	ASU1_10145 ASU1_10580

AIO:	EXH44_04330

HPIZ:

GYM47_11390

NCI:	NCTC10296_00789

NBC:	H3L91_00635

NMUS:

H7A79_1834

AQS:	DKK66_11295

RPI:

Rpic_4742

RPF:	Rpic12D_3665

RIN:	ACS15_5110

SDO:	SD1155_02180 SD1155_02185

CFT:	CFF04554_1611

CFV:	CFVI03293_1633

CFX:	CFV97608_1736

CFZ:

CSG_17420

CAMR:

CAQ16704_0308

CARM:

CARM_0274

BSR:

I33_0250

BSY:	I653_17410

BSN:	BSn5_12650

BSX:	C663_3461(ggaB2)

BHT:	DIC78_13220

BMOJ:

HC660_34600(ggaB)

BWD:	CT694_28360

BMQ:

BMQ_1135

PBUT:

DTO10_26550

PPSR:

I6J18_19380

SA0248

SAV:

SAV0258

SAW:

SAHV_0257

SAH:	SaurJH1_0249

SAJ:	SaurJH9_0243

SAM:

MW0234

SAS:

SAS0235

SAR:

SAR0255

SAC:

SACOL0243

SAX:	USA300HOU_0269

SAA:	SAUSA300_0252

SAO:	SAOUHSC_00228

SAE:

NWMN_0192

SAD:

SAAV_0226

SUU:	M013TW_0239

SUV:	SAVC_01030

SUJ:	SAA6159_00235(tarS)

SUK:	SAA6008_00232

SUC:

ECTR2_219

SUT:	SAT0131_00251

SUQ:	HMPREF0772_10244

SUZ:

MS7_0248

SUD:	ST398NM01_0271

SUX:	SAEMRSA15_02170

SUW:	SATW20_02600

SUG:

SAPIG0271

SUF:	SARLGA251_02220

SAUA:

SAAG_00739

SAUE:

RSAU_000202

SAUN:

SAKOR_00237

SAUS:

SA40_0216

SAUU:

SA957_0231

SAUG:

SA268_0228

SAUZ:

SAZ172_0261

SAUT:

SAI1T1_2001990

SAUJ:

SAI2T2_1001990

SAUK:

SAI3T3_1001990

SAUQ:

SAI4T8_1001990

SAUV:

SAI7S6_1001990

SAUW:

SAI5S5_1001980

SAUX:

SAI6T6_1001990

SAUY:

SAI8T7_1001990

SAUF:

X998_0234

SAB:

SAB0197

SUY:	SA2981_0258

SAUB:

C248_0246

SAUM:

BN843_2570

SAUC:

CA347_265

SAUR:

SABB_01594

SAUI:

AZ30_01295

SAUD:

CH52_04435

SAMS:

NI36_01190

SUH:	SAMSHR1132_02260

SHA:

SH0140

SHH:	ShL2_00067

SSP:	SSP0076 SSP0357 SSP1599

SCA:

SCA_0056

SLG:	SLGD_00394 SLGD_02320

SLN:	SLUG_03900 SLUG_22380

SSD:	SPSINT_2186

SWA:	A284_02040 A284_02045

SPAS:

STP1_0982 STP1_0983

SXY:	BE24_03100 BE24_10195

SXL:	SXYLSMQ121_0385 SXYLSMQ121_1643 SXYLSMQ121_2494

SXO:	SXYL_00388 SXYL_01717 SXYL_02674

SHU:	SHYC_01840

SCAP:

AYP1020_1653(epsJ)

SSCH:

LH95_01700

SAGQ:

EP23_08260

SEQO:

SE1039_21940

SSIF:

AL483_09605 AL483_11825

SCV:	A4G25_07460

SPET:

CEP67_07300 CEP67_08460

SCOH:

BZ166_12515

SKL:	C7J89_02005 C7J89_03600

SHOM:

EGX58_04760

SMUS:

C7J88_04410

SCAR:

DWB96_02360

SCHR:

DWB92_01660

SARL:

SAP2_04730

SPIC:

SAMEA4384060_2471

SSH:	NCTC13712_00204

SDB:	CNQ82_00765

SLLO:

ISP08_02345

SPSD:

JMB28_02435 JMB28_08915

SEDA:

MNY58_01960

SCAQ:

QMO72_02035

SROT:

ML435_01105(tarS)

STAP:

AOB58_2217

SSCU:

CEP64_08335

SFF:	FOB90_06095

SSTE:

SAMEA4384403_0141(kfoC)

MVT:	I6J10_02375

SHV:	AAT16_03725

LGZ:	NCTC10812_02570(hyaD_2)

PLYC:

GXP70_04285

LME:

LEUM_1424

LMM:

MI1_06285

LMK:

LMES_1202

LKI:

LKI_08580

LEC:	LGMK_03595

LGE:	C269_03420

LSU:	A6B45_06730

ERE:	EUBREC_2520

ERT:

EUR_26180

ERA:

ERE_07940

CGV:	CGLAU_09175(epsJ)

CSTR:

CBE89_04500

SGB:

WQO_10750

SFI:

SFUL_2168

SSX:	SACTE_2001 SACTE_2668

SVL:	Strvi_8388

SRC:	M271_29740 M271_29755

SMAL:

SMALA_3088

SSOI:

I1A49_19315

SFA:

Sfla_4283

SBH:

SBI_06509

SDV:	BN159_1018 BN159_5402 BN159_5703

STRP:

F750_2426

SCI:	B446_32755

SXI:	SXIM_15270 SXIM_49020

STRC:

AA958_25165

SPRI:

SPRI_4935

SCZ:	ABE83_24680

SCX:	AS200_06040 AS200_43755

SRW:	TUE45_00552(epsH_1)

SRN:	A4G23_01674(epsJ_1)

SGS:	AVL59_21235

STSI:

A4E84_37930 A4E84_38975

SCAD:

DN051_03245 DN051_05915

SLS:	SLINC_2987 SLINC_2996 SLINC_3051 SLINC_3284 SLINC_7751

SAUO:

BV401_19010

SVU:	B1H20_28805

SLAU:

SLA_3568 SLA_5891

SALJ:

SMD11_0634

SNZ:	DC008_31550

SGE:	DWG14_00906(epsH_1) DWG14_03000(epsJ_1) DWG14_05579(epsH_2) DWG14_05588(epsJ_3) DWG14_08205(epsJ_4)

SLK:	SLUN_13185

SGD:	ELQ87_02770 ELQ87_15565

SCYA:

EJ357_02990 EJ357_15525

SGZ:	C0216_08910 C0216_13325

SVN:	CP980_04260 CP980_07705

SHAW:

CEB94_38070

SRK:	FGW37_24995

SFIC:

EIZ62_22250

SGAL:

CP966_11960 CP966_12030

SPAD:

DVK44_08985

SFY:	GFH48_17080

SAQU:

EJC51_17055 EJC51_17115 EJC51_19180 EJC51_41640

SSUB:

CP968_08290 CP968_33610

SFUG:

CNQ36_02615 CNQ36_11770

STSU:

B7R87_09295

SCHA:

CP983_02895 CP983_24855 CP983_28720

SCOE:

CP976_15095 CP976_39315

STUI:

GCM10017668_04160

SATA:

C5746_17790

SCYG:

S1361_36200(epsH2)

SFEU:

IM697_20735

SLIA:

HA039_24005

SCAL:

I6J39_28655

SPRA:

CP972_32870

SDD:	D9753_03105

SCIR:

STRCI_007429

SJN:	RI060_02380

SKG:	KJK29_01640

SCOA:

QU709_00600 QU709_28395

KAB:	B7C62_09645

KIT:	CFP65_2593

LXL:	KDY119_02624

LXY:	O159_15590

MIP:	AXH82_08125

MICR:

BMW26_01195

MFOL:

DXT68_01315

MWA:	E4K62_17210

MPRT:

ET475_00800 ET475_11915

MOY:	CVS54_00314(epsJ_1)

MCAW:

F6J84_07730

MLZ:	F6J85_16225

MLIQ:

NMQ05_01185

MPAO:

IZR02_01420

SALD:

FVA74_05210

LEU:	Leucomu_09005

LEB:	G7066_06150

LVI:	G7068_15475

LINS:

G7067_08130

AGG:	C1N71_12925

ARL:	AFL94_17660

ARY:	ATC04_09325

ACRY:

AC20117_19765

ACIT:

HPK19_20700

ASUF:

MNQ99_00375

AAI:	AARI_34170

GAR:	AOZ07_07630 AOZ07_17870

GPR:	JQN66_07610

BFA:	Bfae_26480 Bfae_26500

BRX:	BH708_09755 BH708_09765

BRV:	CFK39_05660 CFK39_05665

BGG:	CFK41_03300

PHW:	G7075_00215

SERJ:

SGUI_1221

BLIN:

BLSMQ_3086

BLUT:

EW640_07375

BCAU:

I6G59_00200 I6G59_00225

MIK:	FOE78_12125

MICG:

GJV80_09125

TFU:

Tfu_2173

STRR:

EKD16_04850(epsH)

SRO:	Sros_0992 Sros_8518

TBI:

Tbis_0511

KBU:	Q4V64_03095 Q4V64_16705

STP:	Strop_1692 Strop_2081

SAQ:

Sare_1690

MAU:	Micau_2094 Micau_2815

MIL:	ML5_2201 ML5_5581

MICB:

MicB006_4385 MicB006_5153 MicB006_5919

MTUA:

CSH63_10990 CSH63_14330

MICH:

FJK98_03075

MTEM:

GCE86_03970

MCAB:

HXZ27_03165

MSAG:

GCM10017556_48200

VMA:	VAB18032_00450

MCRA:

ID554_03195 ID554_19765

VER:	HUT12_27720

MCHL:

PVK74_01355 PVK74_04330 PVK74_17060

MFEU:

H1D33_16570

MHAW:

RMN56_01595

ASE:

ACPL_2131

ACTS:

ACWT_2009

ACTL:

L3i22_022230

PLAB:

C6361_18995 C6361_29015

PLAT:

C6W10_06425 C6W10_28685

NAV:	JQS30_15080

MSI:

Msm_1324

MMIL:

sm9_2261

MFC:

BRM9_0685

MSUB:

BK009_06240

METO:

CIT02_10745

» show all

Reference

1 [PMID:14085356]

Authors

NATHENSON SG, STROMINGER JL

Title

ENZYMATIC SYNTHESIS OF N-ACETYLGLUCOSAMINYLRIBITOL LINKAGES IN TEICHOIC ACID FROM STAPHYLOCOCCUS AUREUS, STRAIN COPENHAGEN.

Journal

J Biol Chem 238:3161-9 (1963)

Reference

2 [PMID:23027967]

Authors

Brown S, Xia G, Luhachack LG, Campbell J, Meredith TC, Chen C, Winstel V, Gekeler C, Irazoqui JE, Peschel A, Walker S

Title

Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids.

Journal

Proc Natl Acad Sci U S A 109:18909-14 (2012)
DOI:10.1073/pnas.1209126109

Sequence

[sao:SAOUHSC_00228]

Reference

3 [PMID:27973583]

Authors

Sobhanifar S, Worrall LJ, King DT, Wasney GA, Baumann L, Gale RT, Nosella M, Brown ED, Withers SG, Strynadka NC

Title

Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid beta-glycosyltransferase Involved in Methicillin Resistance.

Journal

PLoS Pathog 12:e1006067 (2016)
DOI:10.1371/journal.ppat.1006067

Sequence

[sav:SAV0258]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.355

IUBMB Enzyme Nomenclature:

2.4.1.355

ExPASy - ENZYME nomenclature database:

2.4.1.355

BRENDA, the Enzyme Database:

2.4.1.355

DBGET integrated database retrieval system