KEGG ENZYME: 2.4.1.356

ENZYME: 2.4.1.356

Entry

EC 2.4.1.356                Enzyme

Name

glucosyl-dolichyl phosphate glucuronosyltransferase;
aglG (gene name)

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-glucuronate:dolichyl phosphate glucuronosyltransferase (configuration-inverting)

Reaction(IUBMB)

UDP-alpha-D-glucuronate + an archaeal dolichyl alpha-D-glucosyl phosphate = UDP + an archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate [RN:R12100]

Reaction(KEGG)

R12100

Substrate

UDP-alpha-D-glucuronate [CPD:C00167];
archaeal dolichyl alpha-D-glucosyl phosphate [CPD:C22506]

Product

UDP [CPD:C00015];
archaeal dolichyl beta-D-glucuronosyl-(1->4)-alpha-D-glucosyl phosphate [CPD:C21902]

Comment

The enzyme, characterized from the halophilic archaeon Haloferax volcanii, participates in the protein N-glycosylation pathway. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60) and is alpha,omega-saturated. However, in vitro the enzyme was also able to act on a substrate with an unsaturated end.

History

EC 2.4.1.356 created 2018

Orthology

K22844

glucosyl-dolichyl phosphate glucuronosyltransferase

Genes

PGH:	FH974_11325

CBER:

B5D82_09585

PEA:	PESP_a2846

AMC:	MADE_1013825

AMH:	I633_14630

HMI:	soil367_10230

CELL:

CBR65_13005

MMAI:

sS8_0472

MEIN:

methR_P1884

TVI:	Thivi_4052

MPUR:

MARPU_05280

TEE:

Tel_13560

NIM:

W01_06470

SDR:	SCD_n02976

APET:

ToN1_15770

AZI:	AzCIB_3669

TMZ:	Tmz1t_3250

THK:	CCZ27_14115 CCZ27_14120

RLG:

Rleg_6733

RLB:	RLEG3_14775

RLN:	J0663_27590

RRG:	J3P73_30125

MET:

M446_3998

MNO:

Mnod_6856

MLG:	CWB41_07410

MPAR:

F7D14_17210

LAP:	ACP90_20640

ACR:

Acry_1519

AMV:	ACMV_15640

ALI:	AZOLI_p60112

ATI:	AL072_32235

AZM:	DM194_27485

AOZ:	HUE56_01020

RCE:

RC1_2529

GEM:

GM21_1651

GEB:

GM18_2476

DDE:

Dde_2889

DAS:

Daes_0089

PSEL:

GM415_02340

DSX:	GD604_00870

DBA:

Dbac_3281

DAL:	Dalk_1973 Dalk_5204

DOV:	DSCO28_33390

DWD:	DSCW_50790

ADE:

Adeh_3054

ACP:	A2cp1_3253

SCU:	SCE1572_14905

PPY:

PPE_01125

PPM:	PPSC2_05815(exoM)

PPO:	PPM_1095(exoM)

PPOL:

X809_05820

PPQ:	PPSQR21_011860

PPOY:

RE92_06070

PMS:	KNP414_06723

PMQ:	PM3016_6345

PMW:

B2K_32080

PTA:	HPL003_13880

PSAB:

PSAB_04740

PDU:	PDUR_06015

PBD:	PBOR_05495

PGM:	PGRAT_05580

POD:	PODO_04695

PAEN:

P40081_05780

PAEF:

R50345_04545

PAEQ:

R50912_05100

PSTE:

PSTEL_05745

PAEA:

R70723_04615

PAEE:

R70331_04620

PAEH:

H70357_05335

PAEJ:

H70737_04805

PBJ:	VN24_15590

PRI:

PRIO_1183

PSON:

JI735_14090

PPEO:

ABE82_05920

PNP:	IJ22_03330

PXL:	BS614_10340

PDH:	B9T62_38130

PKB:	B4V02_19290

PAIH:

ASL14_05850

PPSC:

EHS13_21240

PSOP:

KP014_08260

PTRI:

KDC22_04845

PTJ:	JRJ22_04020

CLT:	CM240_2070

DKU:	Desku_2099

EUZ:	DVS28_a0104

MSA:	Mycsm_05794 Mycsm_06871

MPAG:

C0J29_13165

MCOO:

MCOO_21460

MVA:

Mvan_2677

MNE:	D174_13100

MYN:	MyAD_12860

MVQ:

MYVA_2578

MCHT:

MCHIJ_41770

MTY:	MTOK_22630 MTOK_44050

MSAR:

MSAR_28010

MANY:

MANY_45210

MPOF:

MPOR_29960

CAR:	cauri_0410(exoM)

CMV:	CMUST_02370(exoM)

CTED:

CTEST_02100(exoM)

CCYS:

SAMEA4530656_0260(exoM)

RHB:

NY08_2896

RFA:	A3L23_01108(mftF_5)

RHS:	A3Q41_02279(mftF_2)

RCR:	NCTC10994_00682

GBR:

Gbro_3928

GOR:

KTR9_3858

GTA:	BCM27_20230

GOM:	D7316_02305(wfgD)

GOD:	GKZ92_09835

SNZ:	DC008_29980

SLK:	SLUN_02500

SGX:	H4W23_17630

SMOB:

J7W19_17780

KIT:	CFP65_6460

CUG:	C1N91_10075

CQF:	GBG65_13650

FRN:	F1C15_15175

AUS:	IPK37_06835

PACD:

EGX94_08805

PAUS:

NCTC13651_02097

PPC:	HMPREF9154_2998

NANO:

G5V58_10315

TCU:

Tcur_3588

NOA:	BKM31_54940

NOW:	GBF35_41520

FRA:	Francci3_1580 Francci3_3846

FAL:

FRAAL6119

FSY:	FsymDg_0812 FsymDg_0823

FRI:	FraEuI1c_0126 FraEuI1c_0150

MMAR:

MODMU_0426 MODMU_1369

PSEQ:

AD006_05850

PECQ:

AD017_13670

PHH:	AFB00_11445

PAUT:

Pdca_67620

VER:	HUT12_11950

ACTN:

L083_4864

AFS:

AFR_25005

ATL:	Athai_48990

AMY:	ADJ76_00970

SOO:	FBF35_08225

CYN:	Cyan7425_1956

HHG:	XM38_025220

PSEU:

Pse7367_1203

CYC:	PCC7424_4247

TER:

Tery_4122

MPRO:

BJP34_10360

GLJ:

GKIL_2393

CALO:

Cal7507_5897

NCN:	BZZ01_23925

PLP:	Ple7327_2126

DET:

DET0203

DEB:	DehaBAV1_0150

DEV:

DhcVS_191

DMD:

dcmb_206

DMY:	X793_00940

DUC:	UCH007_02330

DPD:	Deipe_2799

TRA:

Trad_1473

PBOR:

BSF38_01361

AGV:	OJF2_64400(kfoC)

DYS:	G7050_06300

AFD:

Alfi_2222

AOK:	A3BBH6_04990

ACOU:

A5CBH24_06830

CPI:

Cpin_4699

CHIH:

GWR21_01350

PGIN:

FRZ67_01070

FLS:	GLV81_05530

PROE:

H9L23_02700

SBX:	CA265_01775

SLI:

Slin_4093

RHOZ:

GXP67_24590

MTT:	Ftrac_3795

NSD:	BST91_07980

NJA:

NSJP_0243

MMAK:

MMKA1_03830

AST:	Asulf_01103

PYN:

PNA2_1059

THE:

GQS_06820

THM:

CL1_0993

TTD:	A3L14_01120

TIC:	FH039_01050

TCQ:	TIRI35C_0013

MTHR:

MSTHT_0726 MSTHT_1194

MTHE:

MSTHC_2110 MSTHC_2543

MFZ:	AOB57_010390

HAL:	VNG_1067G(exoM)

HSL:	OE_2547R(aglG)

HANR:

LJ422_04375

HAGS:

JT689_05630

HABO:

JRZ79_04095

HALH:

HTSR_0846

HHSR:

HSR6_0873

HSU:	HLASF_1521

HSF:	HLASA_1508

HALR:

EFA46_009400

HDO:	MUK72_10565

SAIM:

K0C01_09225

HARA:

AArcS_2654

HMA:	rrnAC0430(exoM)

HHI:	HAH_1203(exoM)

HHN:	HISP_06155

HAB:	SG26_13805

HTA:	BVU17_05850

HALJ:

G9465_10530

HSIN:

KDQ40_07480

NPH:	NP_1916A(aglG)

NMO:	Nmlp_3535(aglG)

NHO:	HWV23_14205

NSAL:

HWV07_17710

HUT:

Huta_0540

HTI:

HTIA_2653

HALA:

Hrd1104_03855

HASV:

SVXHr_1056

HABN:

HBNXHr_1044

HMU:

Hmuk_2753

HALZ:

E5139_01060

HALL:

LC1Hm_2097(aglG)

HAZP:

GBQ70_01060

HALI:

BV210_00415

HSN:	DV733_14245

HRR:	HZS55_17105

HPEL:

HZS54_20450

HLT:	I7X12_18560

SSAI:

N0B31_08730

HAAD:

MW046_02030

HWA:	HQ_2692A(aglG)

HWC:	Hqrw_3044(aglG)

HVO:	HVO_1529(aglG)

HALE:

G3A49_10765

HLS:	KU306_12725

HLN:	SVXHx_1475(aglg)

HAQ:	DU484_15380

HAJ:	DU500_15400

HAER:

DU502_13480

HRA:	EI982_17695

HLM:	DV707_04345

HLA:

Hlac_1063

HALP:

DOS48_05355

HALB:

EKH57_05755

HEZZ:

EO776_06740

HALQ:

Hrr1229_001120

HSS:	J7656_09890

HSAI:

HPS36_00280

HAZZ:

KI388_04270

SRUB:

C2R22_09330

HAE:	halTADL_1026 halTADL_2410

HALN:

B4589_014270

HALG:

HUG10_00435

HALU:

HUG12_17325

HDF:	AArcSl_2615

HAH:	Halar_1600

HTU:

Htur_2956

HAKZ:

J0X25_01410

NMG:

Nmag_0926

HXA:	Halxa_2341 Halxa_2355

NAT:

NJ7G_1723

NPE:	Natpe_1006

NVR:	FEJ81_05200

NPL:	FGF80_05655

NAY:	HYG81_05445

HJT:	DVR14_14330

HLO:	J0X27_11640

NGE:	Natgr_2244

HRU:	Halru_1002

SAWL:

NGM29_06980

HALV:

NGM15_16180

NOU:	Natoc_2650

HLR:	HALLA_07250

HLC:	CHINAEXTREME09045

NAJ:	B1756_14510

NAG:	AArcMg_2848

NAN:	AArc1_0854

NARA:

QQ977_11750(aglG)

NBG:	DV706_10775

NAS:	GCU68_01305

HDA:	BB347_08855

MER:	MMINT_15130

» show all

Reference

1 [PMID:18631242]

Authors

Yurist-Doutsch S, Abu-Qarn M, Battaglia F, Morris HR, Hitchen PG, Dell A, Eichler J

Title

AglF, aglG and aglI, novel members of a gene island involved in the N-glycosylation of the Haloferax volcanii S-layer glycoprotein.

Journal

Mol Microbiol 69:1234-45 (2008)
DOI:10.1111/j.1365-2958.2008.06352.x

Sequence

[hvo:HVO_1529]

Reference

2 [PMID:28809486]

Authors

Elharar Y, Podilapu AR, Guan Z, Kulkarni SS, Eichler J

Title

Assembling Glycan-Charged Dolichol Phosphates: Chemoenzymatic Synthesis of a Haloferax volcanii N-Glycosylation Pathway Intermediate.

Journal

Bioconjug Chem 28:2461-2470 (2017)
DOI:10.1021/acs.bioconjchem.7b00436

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.356

IUBMB Enzyme Nomenclature:

2.4.1.356

ExPASy - ENZYME nomenclature database:

2.4.1.356

BRENDA, the Enzyme Database:

2.4.1.356

DBGET integrated database retrieval system