KEGG   ENZYME: 2.4.1.361
Entry
EC 2.4.1.361                Enzyme                                 
Name
GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase;
MDIP synthase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:bis(myo-inositol)-1,3'-phosphate 2-beta-D-mannosyltransferase
Reaction(IUBMB)
2 GDP-alpha-D-mannose + bis(myo-inositol) 1,3'-phosphate = 2 GDP + 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate (overall reaction) [RN:R12338];
(1a) GDP-alpha-D-mannose + bis(myo-inositol) 1,3'-phosphate = GDP + 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate [RN:R12339];
(1b) GDP-alpha-D-mannose + 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate = GDP + 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate [RN:R12340]
Reaction(KEGG)
R12338 R12339 R12340
Substrate
GDP-alpha-D-mannose [CPD:C00096];
bis(myo-inositol) 1,3'-phosphate [CPD:C22088];
2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate [CPD:C22090]
Product
GDP [CPD:C00035];
2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate [CPD:C22089];
2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate [CPD:C22090]
Comment
The enzyme from the hyperthermophilic bacterium Thermotoga maritima is involved in the synthesis of the solutes 2-O-(beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate and 2-O-(beta-D-mannosyl-(1->2)-beta-D-mannosyl)-bis(myo-inositol) 1,3'-phosphate.
History
EC 2.4.1.361 created 2019
Orthology
K23395  GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase
Genes
TMA: TM0359
TMM: Tmari_0357
TMI: THEMA_02920
TMW: THMA_0367
TMQ: THMB_0367
TMX: THMC_0367
TPT: Tpet_0560
TNP: Tnap_0995
TRQ: TRQ2_0575
TNA: CTN_0288
THQ: T2812B_02925
THZ: CELL2_02980
THR: TRQ7_02940
 » show all
Reference
1  [PMID:19648237]
  Authors
Rodrigues MV, Borges N, Almeida CP, Lamosa P, Santos H
  Title
A unique beta-1,2-mannosyltransferase of Thermotoga maritima that uses di-myo-inositol phosphate as the mannosyl acceptor.
  Journal
J Bacteriol 191:6105-15 (2009)
DOI:10.1128/JB.00598-09
  Sequence
[tma:TM0359]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.361
IUBMB Enzyme Nomenclature: 2.4.1.361
ExPASy - ENZYME nomenclature database: 2.4.1.361
BRENDA, the Enzyme Database: 2.4.1.361

  All links  
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG REACTION (3)   
   KEGG RCLASS (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (13)   
Protein sequence (11)   
   UniProt (2)   
   SWISS-PROT (2)   
   RefSeq(pep) (7)   
DNA sequence (23)   
   RefSeq(nuc) (23)   
Protein domain (1)   
   InterPro (1)   
All databases (58)   

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