KEGG   ENZYME: 2.4.1.364
Entry
EC 2.4.1.364                Enzyme                                 
Name
protopanaxadiol-type ginsenoside 3-O-glucosyltransferase;
UGT74AE2 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:protopanaxadiol-type ginsenoside 3-O-glucosyltransferase (configuration-retaining)
Reaction(IUBMB)
(1) UDP-alpha-D-glucose + (20S)-protopanaxadiol = UDP + (20S)-ginsenoside Rh2 [RN:R12383];
(2) UDP-alpha-D-glucose + ginsenoside C-K = UDP + ginsenoside F2 [RN:R12384]
Reaction(KEGG)
R12383 R12384
Substrate
UDP-alpha-D-glucose [CPD:C00029];
(20S)-protopanaxadiol [CPD:C20715];
ginsenoside C-K [CPD:C22127]
Product
UDP [CPD:C00015];
(20S)-ginsenoside Rh2 [CPD:C22128];
ginsenoside F2 [CPD:C20779]
Comment
The enzyme, characterized from the plant Panax ginseng, transfers a glucosyl moiety to the free C-3-OH group of (20S)-protopanaxadiol and ginsenoside C-K.
History
EC 2.4.1.364 created 2019
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01110  Biosynthesis of secondary metabolites
Orthology
K23521  protopanaxadiol-type ginsenoside 3-O-glucosyltransferase
Reference
1  [PMID:25320211]
  Authors
Jung SC, Kim W, Park SC, Jeong J, Park MK, Lim S, Lee Y, Im WT, Lee JH, Choi G, Kim SC
  Title
Two ginseng UDP-glycosyltransferases synthesize ginsenoside Rg3 and Rd.
  Journal
Plant Cell Physiol 55:2177-88 (2014)
DOI:10.1093/pcp/pcu147
  Sequence
[ag:AGR44631]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.364
IUBMB Enzyme Nomenclature: 2.4.1.364
ExPASy - ENZYME nomenclature database: 2.4.1.364
BRENDA, the Enzyme Database: 2.4.1.364

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (1)   
   InterPro (1)   
All databases (18)   

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