KEGG   ENZYME: 2.4.1.365
Entry
EC 2.4.1.365                Enzyme                                 
Name
protopanaxadiol-type ginsenoside-3-O-glucoside 2''-O-glucosyltransferase;
UGT94Q2 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:3-O-glucosyl-protopanaxadiol-type ginsenoside 2''-O-glucosyltransferase
Reaction(IUBMB)
(1) UDP-alpha-D-glucose + (20S)-ginsenoside Rh2 = UDP + (20S)-ginsenoside Rg3 [RN:R12385];
(2) UDP-alpha-D-glucose + ginsenoside F2 = UDP + ginsenoside Rd [RN:R12386]
Reaction(KEGG)
R12385 R12386
Substrate
UDP-alpha-D-glucose [CPD:C00029];
(20S)-ginsenoside Rh2 [CPD:C22128];
ginsenoside F2 [CPD:C20779]
Product
UDP [CPD:C00015];
(20S)-ginsenoside Rg3 [CPD:C20778];
ginsenoside Rd [CPD:C20725]
Comment
The enzyme, characterized from the plant Panax ginseng, transfers a glucosyl moiety to the 2'' position of the glucose moiety in the protopanaxadiol-type ginsenoside-3-O-glucosides (20S)-ginsenoside Rh2 and ginsenoside F2.
History
EC 2.4.1.365 created 2019
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01110  Biosynthesis of secondary metabolites
Orthology
K23522  protopanaxadiol-type ginsenoside-3-O-glucoside 2''-O-glucosyltransferase
Reference
1  [PMID:25320211]
  Authors
Jung SC, Kim W, Park SC, Jeong J, Park MK, Lim S, Lee Y, Im WT, Lee JH, Choi G, Kim SC
  Title
Two ginseng UDP-glycosyltransferases synthesize ginsenoside Rg3 and Rd.
  Journal
Plant Cell Physiol 55:2177-88 (2014)
DOI:10.1093/pcp/pcu147
  Sequence
[ag:AGR44632]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.365
IUBMB Enzyme Nomenclature: 2.4.1.365
ExPASy - ENZYME nomenclature database: 2.4.1.365
BRENDA, the Enzyme Database: 2.4.1.365

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (2)   
   InterPro (2)   
All databases (19)   

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