KEGG   ENZYME: 2.4.1.367
Entry
EC 2.4.1.367                Enzyme                                 
Name
ginsenoside 6-O-glucosyltransferase;
UGTPg100 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:ginsenoside 6-O-glucosyltransferase
Reaction(IUBMB)
(1) UDP-alpha-D-glucose + protopanaxatriol = UDP + ginsenoside Rh1 [RN:R12388];
(2) UDP-alpha-D-glucose + ginsenoside F1 = UDP + (20S)-ginsenoside Rg1 [RN:R12387]
Reaction(KEGG)
R12387 R12388
Substrate
UDP-alpha-D-glucose [CPD:C00029];
protopanaxatriol [CPD:C20716];
ginsenoside F1 [CPD:C20780]
Product
UDP [CPD:C00015];
ginsenoside Rh1 [CPD:C22129];
(20S)-ginsenoside Rg1 [CPD:C08946]
Comment
The enzyme, characterized from the plant Panax ginseng, glucosylates the C-6 position of protopanaxatriol and ginsenoside F1.
History
EC 2.4.1.367 created 2019
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01110  Biosynthesis of secondary metabolites
Orthology
K23524  ginsenoside 6-O-glucosyltransferase
Reference
1  [PMID:26032089]
  Authors
Wei W, Wang P, Wei Y, Liu Q, Yang C, Zhao G, Yue J, Yan X, Zhou Z
  Title
Characterization of Panax ginseng UDP-Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rh1 in Metabolically Engineered Yeasts.
  Journal
Mol Plant 8:1412-24 (2015)
DOI:10.1016/j.molp.2015.05.010
  Sequence
[ag:AKQ76388]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.367
IUBMB Enzyme Nomenclature: 2.4.1.367
ExPASy - ENZYME nomenclature database: 2.4.1.367
BRENDA, the Enzyme Database: 2.4.1.367

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (3)   
   InterPro (3)   
All databases (20)   

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