KEGG ENZYME: 2.4.1.369

ENZYME: 2.4.1.369

Entry

EC 2.4.1.369                Enzyme

Name

enterobactin C-glucosyltransferase;
iroB (gene name)

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-glucose:enterobactin 5'-C-beta-D-glucosyltransferase (configuration-inverting)

Reaction(IUBMB)

(1) UDP-alpha-D-glucose + enterobactin = UDP + monoglucosyl-enterobactin [RN:R12469];
(2) UDP-alpha-D-glucose + monoglucosyl-enterobactin = UDP + diglucosyl-enterobactin [RN:R12470];
(3) UDP-alpha-D-glucose + diglucosyl-enterobactin = UDP + triglucosyl-enterobactin [RN:R12471]

Reaction(KEGG)

R12469 R12470 R12471

Substrate

UDP-alpha-D-glucose [CPD:C00029];
enterobactin [CPD:C05821];
monoglucosyl-enterobactin [CPD:C22180];
diglucosyl-enterobactin [CPD:C22181]

Product

UDP [CPD:C00015];
monoglucosyl-enterobactin [CPD:C22180];
diglucosyl-enterobactin [CPD:C22181];
triglucosyl-enterobactin [CPD:C22182]

Comment

The enzyme, found in pathogenic strains of the bacteria Escherichia coli and Salmonella enterica, catalyses the transfer of glucosyl groups to C-5 of one, two, or three of the 2,3-hydroxybenzoyl units of the siderophore enterobactin, forming C-glucosylated derivatives known as salmochelins.

History

EC 2.4.1.369 created 2019

Orthology

K23725

enterobactin C-glucosyltransferase

Genes

ECE:

Z1190

ECS:

ECs_1370

ECF:	ECH74115_1369

ELX:	CDCO157_1309

EOI:	ECO111_1272

EOJ:	ECO26_1324

ECOO:

ECRM13514_1270(iroB)

ECOH:

ECRM13516_1230(iroB)

ESL:

O3K_15730

ESO:

O3O_09565

ESM:

O3M_15715

EUN:	UMNK88_1247

ECP:

ECP_0306

ECV:	APECO1_O1CoBM141(iroB)

ECI:	UTI89_C1122(iroB)

EIH:	ECOK1_1111

ECZ:	ECS88_p0128(iroB)

ECC:	c1254(iroB)

ELO:	EC042_3202(mchA)

ELN:	NRG857_30008(iroB)

EAB:	ECABU_c12110(iroB)

ELU:	UM146_12295

ELC:	i14_1148(iroB)

ELD:	i02_1148(iroB)

ECOI:

ECOPMV1_01082

STY:	STY2890(iroB)

STT:	t2668(iroB)

SEX:	STBHUCCB_28080

SENT:

TY21A_13510

STM:	STM2773(iroB)

SEO:	STM14_3344(iroB)

SEV:	STMMW_27401

SEY:	SL1344_2758(iroB)

SEM:	STMDT12_C28270

SEJ:	STMUK_2761(iroB)

SEB:	STM474_2908(iroB)

SEF:	UMN798_3009(iroB)

SETU:

STU288_14040

SETC:

CFSAN001921_03215

SENR:

STMDT2_26791(iroB)

SEND:

DT104_27751(iroB)

SENI:

CY43_14500

SEEN:

SE451236_19960

SPT:	SPA2629(iroB)

SEK:

SSPA2451

SPQ:	SPAB_03444

SEI:	SPC_2813(iroB)

SEC:	SCH_2704(iroB)

SEH:	SeHA_C2949

SHB:

SU5_03260

SENH:

CFSAN002069_18400

SEEH:

SEEH1578_22680

SEE:	SNSL254_A2968

SENN:

SN31241_38610

SEW:	SeSA_A2915

SEA:	SeAg_B2885

SENS:

Q786_13310

SED:

SeD_A3071

SEG:	SG2678(iroB)

SEL:	SPUL_2765(iroB)

SEGA:

SPUCDC_2751(iroB)

SET:	SEN2619(iroB)

SENA:

AU38_13285

SENO:

AU37_13295

SENV:

AU39_13295

SENQ:

AU40_14960

SENL:

IY59_13870

SENJ:

CFSAN001992_19670

SEEC:

CFSAN002050_20150

SEEB:

SEEB0189_006315

SEEP:

I137_13190

SENB:

BN855_28060

SENE:

IA1_13235

SENC:

SEET0819_20675

SES:	SARI_00205

SALZ:

EOS98_05685

SDY:	SDY_1026(iroB)

SDZ:	Asd1617_01308

ECLE:

ECNIH2_07815

ECLY:

LI62_07670

ECLO:

ENC_19070

EHM:	AB284_18090

ECAN:

CWI88_15310

ENK:	LOC22_17650(iroB)

KPU:	KP1_3611(iroB) KP1_p028(iroB)

KPP:

A79E_1750

KPT:	VK055_5103(iroB)

KPO:	KPN2242_26226

KPNK:

BN49_pII0030(iroB)

EAE:

EAE_03270

EAR:

CCG33326

PGE:	LG71_24425

YRE:	HEC60_09565(iroB)

IZH:	FEM41_21260

GQU:	AWC35_23165

RBAD:

H2866_00495

CUW:	LH390_01880

CHIN:

J5O04_01045

SCAD:

DN051_13795

SRIM:

CP984_01870

SPHV:

F9278_28325 F9278_28335 F9278_28345

SCHA:

CP983_03635 CP983_27930

SMAO:

CAG99_12165 CAG99_12170

SCIR:

STRCI_006084

SHAU:

K9S39_40635

SPIQ:

OHA34_04085

KUT:	JJ691_31790 JJ691_88070 JJ691_97130

CROS:

N8J89_05235

MCRA:

ID554_11935

» show all

Reference

1 [PMID:15598734]

Authors

Fischbach MA, Lin H, Liu DR, Walsh CT

Title

In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase.

Journal

Proc Natl Acad Sci U S A 102:571-6 (2005)
DOI:10.1073/pnas.0408463102

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.369

IUBMB Enzyme Nomenclature:

2.4.1.369

ExPASy - ENZYME nomenclature database:

2.4.1.369

BRENDA, the Enzyme Database:

2.4.1.369

All links

Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (3)   
Gene (125)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (116)   
   KEGG MGENES (8)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
DNA sequence (6)   
   GenBank (3)   
   EMBL (3)   
Protein domain (4)   
   InterPro (4)   
All databases (146)   

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