KEGG   ENZYME: 2.4.1.370
Entry
EC 2.4.1.370                Enzyme                                 
Name
inositol phosphorylceramide mannosyltransferase;
SUR1 (gene name);
CSH1 (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
GDP-alpha-D-mannose + a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine = a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(alpha-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine + GDP [RN:R12472]
Reaction(KEGG)
R12472
Substrate
GDP-alpha-D-mannose [CPD:C00096];
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine
Product
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(alpha-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine;
GDP [CPD:C00035]
Comment
The simplest complex sphingolipid of yeast, inositol-phospho-alpha-hydroxyphytoceramide (IPC), is usually mannosylated to yield mannosyl-inositol-phospho-alpha hydroxyphytoceramide (MIPC). The enzyme is located in the Golgi apparatus, and utilizes GDP-mannose as the mannosyl group donor. It consists of a catalytic subunit (SUR1 or CSH1) and a regulatory subunit (CSG2).
History
EC 2.4.1.370 created 2019
Orthology
K22721  inositol phosphorylceramide mannosyltransferase catalytic subunit
Genes
EAF: 111712011 111715824
HRO: HELRODRAFT_193660 HELRODRAFT_85985
LGI: LOTGIDRAFT_165932 LOTGIDRAFT_234732
PVUL: 126819227
PCAN: 112554310 112554653
BGT: 106072066 106077463
GAE: 121380215
HRF: 124134110
HRJ: 124289679
CRG: 105322441
CVN: 111131405 111131556
MYI: 110451184
PMAX: 117335231
MMER: 123526579 123526584 123528003 123532711 123534484 123537963 123542758 123548677 123553963 123555295 123555316 123559195 123559533 123566664
RPHI: 132713300 132718273 132722925 132722927 132722928 132726180 132732508 132739289 132739627 132754202 132755029 132755882 132755883
DPOL: 127831054 127831636 127853019 127853029
OBI: 106875328
OSN: 115231739
LAK: 106161453 106169507 106173083 106173093 106180932 106181098
MNG: MNEG_2602 MNEG_8864
CSL: COCSUDRAFT_38902 COCSUDRAFT_57606 COCSUDRAFT_62728 COCSUDRAFT_65781 COCSUDRAFT_66191
CVR: CHLNCDRAFT_10358 CHLNCDRAFT_137953 CHLNCDRAFT_141367 CHLNCDRAFT_142222
APRO: F751_2198 F751_2890
MIS: MICPUN_101129
GSL: Gasu_00650 Gasu_19240
SCE: YBR161W(CSH1) YPL057C(SUR1)
SEUB: DI49_1188 DI49_5403
SPAO: SPAR_B02600 SPAR_P02090
KLA: KLLA0_B09768g
KMX: KLMA_30359(SUR1)
LTH: KLTH0E11946g
VPO: Kpol_457p1
ZRO: ZYRO0F08800g
CGR: CAGL0M05621g CAGL0M07315g
NCS: NCAS_0B02330(NCAS0B02330) NCAS_0C02270(NCAS0C02270)
NDI: NDAI_0C05350(NDAI0C05350) NDAI_0E02960(NDAI0E02960)
TPF: TPHA_0I02040(TPHA0I02040) TPHA_0L01480(TPHA0L01480)
TBL: TBLA_0A00490(TBLA0A00490) TBLA_0H03450(TBLA0H03450)
TGB: HG536_0H01270
TDL: TDEL_0B01240(TDEL0B01240)
KAF: KAFR_0A01170(KAFR0A01170) KAFR_0E03040(KAFR0E03040)
KNG: KNAG_0A02110(KNAG0A02110) KNAG_0A03890(KNAG0A03890)
ZMK: HG535_0A07810
PPA: PAS_chr1-3_0218
DHA: DEHA2B11440g
PIC: PICST_83423
PGU: PGUG_01730
SPAA: SPAPADRAFT_60194
LEL: PVL30_003602(CSH1)
CAL: CAALFM_C209150WA(MIT1)
CTP: CTRG_01978
COT: CORT_0C04600
CDU: CD36_23310
CTEN: CANTEDRAFT_100431
CLU: CLUG_00533
CLUS: A9F13_15g01056
CAUR: CJI96_0002410
SLB: AWJ20_3499(SUR1)
PKZ: C5L36_0B12270
BNN: FOA43_002655
BBRX: BRETT_001537
OPA: HPODL_01245
SLUD: SCDLUD_001988
NCR: NCU07761
NTE: NEUTE1DRAFT109478(NEUTE1DRAFT_109478) NEUTE1DRAFT59032(NEUTE1DRAFT_59032)
SMP: SMAC_05159 SMAC_12617
PAN: PODANSg4680 PODANSg8472
PBEL: QC761_206540 QC761_703680
PPSD: QC762_206540 QC762_703680
PPSP: QC763_206540 QC763_703680
PPSA: QC764_206540 QC764_703680
TTT: THITE_2073944 THITE_2114740 THITE_2155406
MTM: MYCTH_2301633
MGR: MGG_13744 MGG_15239
PPEI: PpBr36_02740
PGRI: PgNI_02317
TMN: UCRPA7_400
SSCK: SPSK_06290 SPSK_07656
FGR: FGSG_03803
FPU: FPSE_04573
FPOA: FPOAC1_006219
FVN: FVRRES_06821
FVR: FVEG_12942 FVEG_12987
FOX: FOXG_16891 FOXG_16893
NHE: NECHADRAFT_106413 NECHADRAFT_26612 NECHADRAFT_51853 NECHADRAFT_55741 NECHADRAFT_88959
FFC: NCS54_01314200
FKR: NCS57_01258100 NCS57_01300800
FMU: J7337_013704
TRE: TRIREDRAFT_120923 TRIREDRAFT_45252 TRIREDRAFT_64925
TRR: M419DRAFT_108301 M419DRAFT_108458 M419DRAFT_85693
MAW: MAC_06157 MAC_06266 MAC_09448
MAJ: MAA_04377 MAA_07951 MAA_09567 MAA_11118
PCHM: VFPPC_00030 VFPPC_08320 VFPPC_12721
CMT: CCM_01739 CCM_08818 CCM_09270
AMUS: LMH87_009642 LMH87_010072
PLJ: VFPFJ_00279 VFPFJ_01501 VFPFJ_04198 VFPFJ_08222 VFPFJ_09746 VFPFJ_10895 VFPFJ_10969 VFPFJ_11324 VFPFJ_11649 VFPFJ_11698
PTKZ: JDV02_001925 JDV02_001980 JDV02_003196 JDV02_004876 JDV02_009896
VAL: VDBG_05673
VDA: VDAG_04881 VDAG_07615
CFJ: CFIO01_06606
CLUP: CLUP02_13161
CHIG: CH63R_05415
SAPO: SAPIO_CDS6649
ELA: UCREL1_10331
PFY: PFICI_11318
SSL: SS1G_00432
BFU: BCIN_03g04220 BCIN_04g06200
MBE: MBM_03773
PSCO: LY89DRAFT_600211 LY89DRAFT_641076 LY89DRAFT_696850
GLZ: GLAREA_07063
ANI: ANIA_06534
AFM: AFUA_6G04680
ACT: ACLA_044880 ACLA_095870
NFI: NFIA_051220 NFIA_094100
AOR: AO090005001189 AO090701000073
ANG: An15g00630
AFV: AFLA_004563
ALUC: AKAW2_40009S AKAW2_60622S
ACHE: ACHE_50208S
APUU: APUU_10734S APUU_50134A
PCS: N7525_001892 N7525_009556
PDP: PDIP_18130
POU: POX_c04666
TMF: EYB26_000008 EYB26_003714 EYB26_009712
TRG: TRUGW13939_07174 TRUGW13939_07551 TRUGW13939_10859
CIM: CIMG_02806
CPW: CPC735_036290
URE: UREG_03030
PBL: PAAG_03525
PBN: PADG_06303
ABE: ARB_03983 ARB_04086
TVE: TRV_01806 TRV_03867
AJE: HCAG_08692
BGH: BDBG_07766
PNO: SNOG_05811 SNOG_09174(SNOG_09175)
PTE: PTT_16724
BZE: COCCADRAFT_7971
BSC: COCSADRAFT_137254
BOR: COCMIDRAFT_99036
AALT: CC77DRAFT_145490 CC77DRAFT_960406
ARAB: EKO05_0003000
ZTR: MYCGRDRAFT_49574 MYCGRDRAFT_74362
PFJ: MYCFIDRAFT_211649 MYCFIDRAFT_86687
FFU: CLAFUR5_07576
CBET: CB0940_09709
BCOM: BAUCODRAFT_47228
NPA: UCRNP2_5554
TML: GSTUM_00006149001
SPO: SPAC17G8.11c(imt3) SPAC2F3.01(imt1) SPCC4F11.04c(imt2)
SOM: SOMG_02808(imt3) SOMG_04619(imt1) SOMG_04912(imt2)
CNE: CNH00360
CNB: CNBL0340
CNG: CNAG_07873
CGI: CGB_H0400C
CDEU: CNBG_2517
TMS: TREMEDRAFT_40831
TASA: A1Q1_02468
CCAC: CcaHIS019_0103160(CcaverHIS019_0103160)
TVS: TRAVEDRAFT_70229
DSQ: DICSQDRAFT_106213
PCO: PHACADRAFT_249466
SHS: STEHIDRAFT_95404
HIR: HETIRDRAFT_34312
ADL: AURDEDRAFT_52940
FME: FOMMEDRAFT_110885 FOMMEDRAFT_140591
GTR: GLOTRDRAFT_109709 GLOTRDRAFT_113658
LBC: LACBIDRAFT_231771
CCI: CC1G_00390
ABP: AGABI1DRAFT91417(AGABI1DRAFT_91417)
ABV: AGABI2DRAFT142533(AGABI2DRAFT_142533)
MPR: MPER_15070
MRR: Moror_7454
MORE: E1B28_004245
SCM: SCHCO_02183217(SCHCODRAFT_02183217) SCHCO_02291447(SCHCODRAFT_02291447)
CPUT: CONPUDRAFT_102860
WSE: WALSEDRAFT_60299
WIC: J056_000619
UMA: UMAG_15072
PFP: PFL1_05915
SGRA: EX895_004279
MGL: MGL_0392
MRT: MRET_2213
MSYM: MSY001_3200(OCH1)
PGR: PGTG_12162 PGTG_19402
MLR: MELLADRAFT_117884 MELLADRAFT_49485
MBR: MONBRDRAFT_2363 MONBRDRAFT_31860 MONBRDRAFT_8658
SRE: PTSG_04074 PTSG_05645 PTSG_06348
SMIN: v1.2.010590.t1(symbB.v1.2.010590.t1) v1.2.015706.t1(symbB.v1.2.015706.t1) v1.2.025490.t1(symbB.v1.2.025490.t1) v1.2.025490.t2(symbB.v1.2.025490.t2)
PSOJ: PHYSODRAFT_358700 PHYSODRAFT_486818
SPAR: SPRG_08368
EHX: EMIHUDRAFT_197740 EMIHUDRAFT_433823 EMIHUDRAFT_471622
NGR: NAEGRDRAFT_72157
FSM: CCS41_13915
WOC: BA177_06640
CHRO: CXB49_08000
CRZ: D1345_03165
CHAE: CH06BL_06040
BOK: DM82_1689
BOC: BG90_3021
CBX: Cenrod_2388
MBAC: BN1209_1153
FPHO: SHINM1_018310
PTC: phytr_4680
AGR: AGROH133_08736
ATF: Ach5_24700
ALF: CFBP5473_02425
RIR: BN877_I2670
AVI: Avi_3933
ROY: G3A56_12840
SHZ: shn_26300
STAR: G3545_03850
HDI: HDIA_3838
NOH: G5V57_01045
PHR: C6569_01000
PSTG: E8M01_18500
ZMN: Za10_1038
ZMP: Zymop_1037
APT: APA01_03500
APW: APA42C_03500
APF: APA03_03500
APU: APA07_03500
APG: APA12_03500
APQ: APA22_03500
APX: APA26_03500
APZ: APA32_03500
APK: APA386B_1831
APER: A0U91_05110
AASC: A4S02_10855
AOY: EOV40_001775
ABG: Asbog_00540
BOB: GN304_03925
BOMB: GT348_07535
EBLA: JGUZn3_08170
LCK: HN018_08545
SKT: IGS68_31790
SMUC: JL100_034635
TUR: AT726_11265
TSG: HLK68_11455
STRR: EKD16_25235
CGC: Cyagr_2110
ANB: ANA_C13067
CCUR: IAR63_16570
CRK: L3I90_08775
RCS: NIES932_19570
ALAX: NIES50_68450
RBA: RB9614(sur1)
BVO: Pan97_07240
ABAC: LuPra_06262
PDI: BDI_3159
PARC: CI960_22050
ARK: D6B99_16375
PHE: Phep_0687
PSTY: BFS30_25235 BFS30_25240
PGS: CPT03_02290 CPT03_19540
SHT: KO02_01450
HYZ: AXW84_14380
FBA: FIC_00838
EEN: BBD30_11650
ELB: VO54_03588
EGO: BBD34_04390
ELZ: FCS00_15970
CHRY: CEY12_06510
CPIP: CJF12_02230
CIL: EG358_11970
CTAI: NCTC12078_00676
CBP: EB354_07880
CCAB: PFY12_01870
CCAS: EIB73_01185
EVA: EIB75_05370
 » show all
Reference
1  [PMID:9323360]
  Authors
Beeler TJ, Fu D, Rivera J, Monaghan E, Gable K, Dunn TM
  Title
SUR1 (CSG1/BCL21), a gene necessary for growth of Saccharomyces cerevisiae in the presence of high Ca2+ concentrations at 37 degrees C, is required for mannosylation of inositolphosphorylceramide.
  Journal
Mol Gen Genet 255:570-9 (1997)
DOI:10.1007/s004380050530
  Sequence
[sce:YPL057C YBR036C]
Reference
2  [PMID:9395539]
  Authors
Dean N, Zhang YB, Poster JB
  Title
The VRG4 gene is required for GDP-mannose transport into the lumen of the Golgi in the yeast, Saccharomyces cerevisiae.
  Journal
J Biol Chem 272:31908-14 (1997)
DOI:10.1074/jbc.272.50.31908
Reference
3  [PMID:12954640]
  Authors
Uemura S, Kihara A, Inokuchi J, Igarashi Y
  Title
Csg1p and newly identified Csh1p function in mannosylinositol phosphorylceramide synthesis by interacting with Csg2p.
  Journal
J Biol Chem 278:45049-55 (2003)
DOI:10.1074/jbc.M305498200
  Sequence
[sce:YBR161W YPL057C YBR036C]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.370
IUBMB Enzyme Nomenclature: 2.4.1.370
ExPASy - ENZYME nomenclature database: 2.4.1.370
BRENDA, the Enzyme Database: 2.4.1.370

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (1477)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (414)   
   KEGG MGENES (1062)   
Protein sequence (18)   
   UniProt (14)   
   SWISS-PROT (2)   
   RefSeq(pep) (2)   
DNA sequence (6)   
   RefSeq(nuc) (4)   
   EMBL (2)   
Protein domain (3)   
   InterPro (3)   
All databases (1509)   

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