Entry
Name
GDP-Man:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-mannosyltransferase;
wbaZ (gene name);
rfbZ (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-alpha-D-mannose:alpha-D-mannopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 3-alpha-mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
GDP-alpha-D-mannose + alpha-D-galactosyl-diphospho-ditrans-octacis-undecaprenol = GDP + alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und [RN:
R12741 ]
Reaction(KEGG)
Substrate
GDP-alpha-D-mannose [CPD:
C00096 ];
alpha-D-galactosyl-diphospho-ditrans-octacis-undecaprenol
Product
GDP [CPD:
C00035 ];
alpha-D-Man-(1->3)-alpha-D-Gal-PP-Und
Comment
The enzyme, present in Salmonella strains that belong to group C2, participates in the biosynthesis of the repeat unit of O antigens produced by these strains.
History
EC 2.4.1.379 created 2021
Orthology
K25196 O-antigen biosynthesis alpha-1,3-mannosyltransferase
Genes
Taxonomy
Reference
Authors
Brown PK, Romana LK, Reeves PR.
Title
Cloning of the rfb gene cluster of a group C2 Salmonella strain: comparison with the rfb regions of groups B and D.
Journal
Reference
Authors
Brown PK, Romana LK, Reeves PR.
Title
Molecular analysis of the rfb gene cluster of Salmonella serovar muenchen (strain M67): the genetic basis of the polymorphism between groups C2 and B.
Journal
Sequence
Reference
Authors
Liu D, Haase AM, Lindqvist L, Lindberg AA, Reeves PR.
Title
Glycosyl transferases of O-antigen biosynthesis in Salmonella enterica: identification and characterization of transferase genes of groups B, C2, and E1.
Journal
Sequence
Reference
Authors
Zhao X, Dai Q, Jia R, Zhu D, Liu M, Wang M, Chen S, Sun K, Yang Q, Wu Y, Cheng A.
Title
Two Novel Salmonella Bivalent Vaccines Confer Dual Protection against Two Salmonella Serovars in Mice.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.379