KEGG   ENZYME: 2.4.1.383
Entry
EC 2.4.1.383                Enzyme                                 
Name
GDP-Man:alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und beta-1,4-mannosyltransferase;
wbaO (gene name);
rfbO (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:alpha-L-rhamnopyranosyl-(1->3)-alpha-D-galactopyranosyl-diphospho-ditrans,octacis-undecaprenol 4II-beta-mannosyltransferase (configuration inverting)
Reaction(IUBMB)
GDP-alpha-D-mannose + alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und = GDP + beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und [RN:R12745]
Reaction(KEGG)
R12745(G)
Substrate
GDP-alpha-D-mannose [CPD:C00096];
alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und
Product
GDP [CPD:C00035];
beta-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-PP-Und
Comment
The enzyme participates in the biosynthesis of the O antigens produced by group E and D2 strains of the pathogenic bacterium Salmonella enterica.
History
EC 2.4.1.383 created 2021
Orthology
K25200  O-antigen biosynthesis beta-1,4-mannosyltransferase
Reference
1  [PMID:8021222]
  Authors
Xiang SH, Hobbs M, Reeves PR.
  Title
Molecular analysis of the rfb gene cluster of a group D2 Salmonella enterica strain: evidence for its origin from an insertion sequence-mediated recombination event between group E and D1 strains.
  Journal
J Bacteriol 176:4357-65 (1994)
DOI:10.1128/jb.176.14.4357-4365.1994
  Sequence
[ag:AAB48191]
Reference
2
  Authors
Zhao, Y., Biggins, J. B. and Thorson, J. S.
  Title
Acceptor specificity of Salmonella GDP-Man:alpha-L-Rha-(1->3)-alpha-D- Gal- PP-Und beta(1->4)-mannosyltransferase: A simplified assay based on unnatural acceptors.
  Journal
J Am Chem Soc 120:12986-12987 (1998)
Reference
3  [PMID:10520265]
  Authors
Zhao Y, Thorson JS.
  Title
Chemoenzymatic synthesis of the Salmonella group E1 core trisaccharide using a recombinant beta-(1-->4)-mannosyltransferase.
  Journal
Carbohydr Res 319:184-91 (1999)
DOI:10.1016/s0008-6215(99)00116-0
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.383
IUBMB Enzyme Nomenclature: 2.4.1.383
ExPASy - ENZYME nomenclature database: 2.4.1.383
BRENDA, the Enzyme Database: 2.4.1.383

  All links  
Chemical substance (4)   
   KEGG GLYCAN (4)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
All databases (8)   

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