KEGG   ENZYME: 2.4.1.386
Entry
EC 2.4.1.386                Enzyme                                 
Name
GlcNAc-beta-1,3-Gal beta-1,6-N-acetylglucosaminyltransferase (distally acting);
UDP-GlcNAc:GlcNAcbeta1-3Gal(-R) beta1-6(GlcNAc to Gal) N-acetylglucosaminyltransferase;
dIGnT;
C2GnT2 (misleading)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminide 6-beta-N-acetylglucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-R = UDP + beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R [RN:R12944]
Reaction(KEGG)
R12944(G)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-R
Product
UDP [CPD:C00015];
beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R
Comment
Involved in the production of milk oligosaccharides in the lacto-N-triose (LNT) series. Cf. EC 2.4.1.150 (N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase; cIGnT) and EC 2.4.1.148 (acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase).
History
EC 2.4.1.386 created 2021
Reference
1  [PMID:6490658]
  Authors
Piller F, Cartron JP, Maranduba A, Veyrieres A, Leroy Y, Fournet B
  Title
Biosynthesis of blood group I antigens. Identification of a UDP-GlcNAc:GlcNAc beta 1-3Gal(-R) beta 1-6(GlcNAc to Gal) N-acetylglucosaminyltransferase in hog gastric mucosa.
  Journal
J Biol Chem 259:13385-90 (1984)
DOI:10.1016/S0021-9258(18)90706-4
Reference
2  [PMID:9915862]
  Authors
Yeh JC, Ong E, Fukuda M
  Title
Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches.
  Journal
J Biol Chem 274:3215-21 (1999)
DOI:10.1074/jbc.274.5.3215
  Sequence
[hsa:9245]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.386
IUBMB Enzyme Nomenclature: 2.4.1.386
ExPASy - ENZYME nomenclature database: 2.4.1.386
BRENDA, the Enzyme Database: 2.4.1.386
CAS: 85638-40-0

  All links  
Chemical substance (4)   
   KEGG COMPOUND (2)   
   KEGG GLYCAN (2)   
Chemical reaction (1)   
   KEGG REACTION (1)   
All databases (5)   

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