KEGG ENZYME: 2.4.1.52

ENZYME: 2.4.1.52

Entry

EC 2.4.1.52                 Enzyme

Name

poly(glycerol-phosphate) alpha-glucosyltransferase;
UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase;
uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase;
tagE (gene name);
UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-glucose:4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol alpha-D-glucosyltransferase (configuration-retaining)

Reaction(IUBMB)

n UDP-alpha-D-glucose + 4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-{poly[(2R)-2-alpha-D-glucosyl-1-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R12807 R12862]

Reaction(KEGG)

R12807 R12862(G)

Substrate

UDP-alpha-D-glucose [CPD:C00029];
4-O-{poly[(2R)-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C22411]

Product

UDP [CPD:C00015];
4-O-{poly[(2R)-2-alpha-D-glucosyl-1-glycerophospho]-(2R)-glycerophospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C22412]

Comment

Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls. This enzyme, isolated from Bacillus subtilis 168, adds an alpha-D-glucose to the free OH groups of the glycerol units. The enzyme has a strong preference for UDP-alpha-glucose as the sugar donor. It has no activity with poly(ribitol phosphate).

History

EC 2.4.1.52 created 1972, modified 2017

Pathway

ec00552

Teichoic acid biosynthesis

Orthology

K00712

poly(glycerol-phosphate) alpha-glucosyltransferase

Genes

ETO:	RIN69_19325

ETE:

ETEE_3362

EDW:	QY76_13070

EDL:	AAZ33_07150

PSKY:

A6B44_08675

AIO:	EXH44_04335

ABM:

ABSDF2312

ACC:	BDGL_000003(tagE)

ALC:	OTEC02_15270

ACV:	AMD27_04695

AWG:	GFH30_10175

ABOU:

ACBO_11520(tagE)

IGN:	MMG00_00790

NST:	Nstercoris_01989

SDO:	SD1155_04980 SD1155_05610

PCON:

B0A89_07635

PAMN:

JCM7685_1531

SARI:

H5J25_04885

CHA:	CHAB381_1475

BSU:	BSU35730(tagE)

BSR:

I33_3702

BSH:	BSU6051_35730(tagE)

BSUT:

BSUB_03806(tagE)

BSUL:

BSUA_03806(tagE)

BSN:	BSn5_08780

BSQ:	B657_35730(tagE)

BSP:	U712_17935

BAMP:

B938_16875

BAMT:

AJ82_18555

BAO:	BAMF_3412(tagE)

BAZ:	BAMTA208_18080(tagE)

BQL:	LL3_03707(tagE)

BXH:	BAXH7_03696(tagE)

BSTR:

QI003_21310(tagE)

BPU:

BPUM_3229

BPUS:

UP12_16725

BXI:	BK049_10725

BALT:

CFN77_17145

BAER:

BAE_05075

BSAF:

BSL056_17860

BCAB:

EFK13_18390

BACW:

QR42_16230

BACL:

BS34A_38860(tagE)

BALM:

BsLM_3589

BZH:	NF868_15050

BAEI:

RE735_03005

VIG:	BKP57_07905

SAU:	SA0522 SA0523

SAV:	SAV0564 SAV0565

SAW:	SAHV_0562 SAHV_0563

SAH:	SaurJH1_0601 SaurJH1_0602

SAJ:	SaurJH9_0587 SaurJH9_0588

SAM:	MW0519 MW0520

SAS:	SAS0522 SAS0523

SAR:	SAR0568 SAR0569

SAC:	SACOL0052 SACOL0611 SACOL0612

SAX:	USA300HOU_0558 USA300HOU_0559

SAA:	SAUSA300_0549 SAUSA300_0550

SAO:	SAOUHSC_00547 SAOUHSC_00548

SAE:	NWMN_0526 NWMN_0527

SAD:	SAAV_0527 SAAV_0528

SUU:	M013TW_0551 M013TW_0552

SUV:	SAVC_02410 SAVC_02415

SUE:	SAOV_0599 SAOV_0600c

SUJ:	SAA6159_00518 SAA6159_00519

SUK:	SAA6008_00572 SAA6008_00573

SUC:	ECTR2_518 ECTR2_519

SUT:	SAT0131_00625 SAT0131_00626

SUQ:	HMPREF0772_12624 HMPREF0772_12625

SUZ:	MS7_0554 MS7_0555

SUD:	ST398NM01_0638 ST398NM01_0640

SUX:	SAEMRSA15_04910 SAEMRSA15_04920

SUW:	SATW20_06340 SATW20_06350

SUG:	SAPIG0638 SAPIG0640

SUF:	SARLGA251_05000 SARLGA251_05010

SAUA:

SAAG_00985 SAAG_00986

SAUE:

RSAU_000518 RSAU_000519

SAUN:

SAKOR_00552 SAKOR_00553

SAUS:

SA40_0504 SA40_0505

SAUU:

SA957_0519 SA957_0520

SAUG:

SA268_0517 SA268_0518

SAUZ:

SAZ172_0566 SAZ172_0567

SAUT:

SAI1T1_2000400 SAI1T1_2004340 SAI1T1_2004350

SAUJ:

SAI2T2_1000400 SAI2T2_1004360 SAI2T2_1004370

SAUK:

SAI3T3_1000400 SAI3T3_1004350 SAI3T3_1004360

SAUQ:

SAI4T8_1000400 SAI4T8_1004340 SAI4T8_1004350

SAUV:

SAI7S6_1000400 SAI7S6_1004350 SAI7S6_1004360

SAUW:

SAI5S5_1000400 SAI5S5_1004310 SAI5S5_1004320

SAUX:

SAI6T6_1000400 SAI6T6_1004320 SAI6T6_1004330

SAUY:

SAI8T7_1000400 SAI8T7_1004350 SAI8T7_1004360

SAUF:

X998_0054 X998_0606 X998_0607

SAB:	SAB0514 SAB0515c

SUY:	SA2981_0541 SA2981_0542

SAUB:

C248_0639 C248_0640

SAUM:

BN843_5580 BN843_5590

SAUC:

CA347_580 CA347_581

SAUR:

SABB_00615 SABB_00616

SAUI:

AZ30_02855 AZ30_02860

SAUD:

CH52_02930 CH52_02935

SAMS:

NI36_02805 NI36_02810

SUH:	SAMSHR1132_05080 SAMSHR1132_05090

SER:

SERP0208

SEP:	SE_0332 SE_2393

SEPP:

SEB_00254

SEPS:

DP17_1426 DP17_1641

SHA:

SH2251

SCA:	SCA_2110(tagE)

SLG:	SLGD_00512 SLGD_02180

SLN:	SLUG_05110 SLUG_21540

SDT:

SPSE_0282

SWA:	A284_11030

SPAS:

STP1_1545 STP1_1652

SXY:	BE24_04185

SXL:	SXYLSMQ121_1423

SXO:	SXYL_01509

SCAP:

AYP1020_2024(gtf1_2) AYP1020_2194(tagE_2) AYP1020_2313(tagE_3)

SSCZ:

RN70_02040

SEQO:

SE1039_26270

SSIF:

AL483_11575

SCV:	A4G25_09675

SPET:

CEP67_06460 CEP67_06465

SCOH:

BZ166_05120

SNL:	BJD96_00780 BJD96_00785

SFQ:	C7J90_04485

SCAR:

DWB96_11705

SARL:

SAP2_17890

SPIC:

SAMEA4384060_0442(tagE_4)

SSH:	NCTC13712_00516(tagE_1) NCTC13712_00517(tagE_2)

SSIM:

SAMEA4384339_0211(tagE_2) SAMEA4384339_0513(tagE_3) SAMEA4384339_0514(tagE_4)

SDB:	CNQ82_03010

SLLO:

ISP08_08060

SSAC:

I6I31_05590

SDEV:

Q2T90_08120

SROT:

ML435_02605 ML435_02610

SSCU:

CEP64_10590 CEP64_10685 CEP64_13970

SFF:	FOB90_11085

MVT:	I6J10_00150

MARY:

LAU42_10770

EAN:

Eab7_2556

EXM:	U719_14295

EXU:	ESP131_09260 ESP131_09305

EACE:

KKI46_07095

LLA:	L76469(yohH) L78550(yohJ)

LLK:	LLKF_1561(yohH) LLKF_1562(yohJ)

LLT:	CVCAS_1364(yohH)

LLS:	lilo_1372(yohH) lilo_1373(yohJ)

LLD:	P620_07955 P620_07960

LLX:	NCDO2118_1463(gtf1) NCDO2118_1464

LLJ:	LG36_0924(yohJ) LG36_0925(yohH)

LLW:	kw2_0793(gtfA)

LACT:

D7I46_05135 D7I46_05140 D7I46_05465 D7I46_05470 D7I46_07320

LACK:

FLP15_10075 FLP15_12470

SPN:

SP_1758

SPW:

SPCG_1734

SJJ:

SPJ_1655

SNV:	SPNINV200_15810

SNE:	SPN23F17670

SPV:

SPH_1869

SNM:	SP70585_1798

SNI:	INV104_15020

SAG:

SAG1448

SAN:

gbs1517

SAK:

SAK_1481

SGC:

A964_1362

SAGS:

SaSA20_1189(gtf1)

SAGM:

BSA_15290

SAGI:

MSA_15720

SAGR:

SAIL_15090

SAGT:

GBSCOH1_1240

SAGE:

EN72_08010

SAGG:

EN73_06800

SAGN:

W903_1463(gtfA)

SAGJ:

ID870_02400(gtfA)

STC:

str0413

STL:

stu0413

STE:

STER_0452

STN:

STND_0410

STU:	STH8232_0516

STW:

Y1U_C0398

STHE:

T303_03190

STHS:

AVT04_02815

SGO:	SGO_0975(gtaA)

SMB:

smi_1648

SOR:

SOR_1575

SCP:	HMPREF0833_11288(gtfA) HMPREF0833_11303

SCF:	Spaf_1925(gtf1)

SSR:	SALIVB_0409 SALIVB_0624

STF:	Ssal_00683 Ssal_01782(tagE)

STJ:	SALIVA_0390 SALIVA_1463 SALIVA_1698

STRS:

SSAL8618_02220 SSAL8618_07190 SSAL8618_08365

SSAH:

HSISS4_00330 HSISS4_01314 HSISS4_01542

SANS:

DK43_06790

SOI:	I872_07235

SIK:

K710_0476

SIQ:	DQ08_02285

SIO:	DW64_02270

SIZ:	SI82_02520

SLU:

KE3_0869

SIG:	N596_06355

SIP:	N597_08235

STV:	V470_07710

SPAT:

A0O21_01935

SSOB:

DK181_06840(gtfA)

SEQI:

A6J79_00935 A6J79_04935(gtfA)

SKI:	D7D50_03995(gtfA)

SRAT:

FY406_07895(gtfA)

SPLR:

C0J00_05990(gtfA)

SVB:	NCTC12167_00457(tagE_1) NCTC12167_01334(tagE_2)

SPSU:

NCTC13786_00804(gtaA)

SCHJ:

DDV21_007170(gtfA)

SPOC:

NCTC10925_00426(gtaA)

SLAT:

J4854_08425 J4854_09455(gtfA)

SAUP:

NCTC3168_00949(tagE)

SURN:

NCTC13766_00260(tagE)

SACO:

SAME_01502(tagE)

SVF:	NCTC3166_01799(tagE)

SOS:	INT76_01865(gtfA)

FPEN:

KIW23_05475

LDE:	LDBND_1203

LKE:	WANG_p1126

LAW:	LACWKB8_0712

LAMY:

B1745_02560

LKL:	DKL58_03520

LAPI:

DKL56_02860 DKL56_02865 DKL56_02870

LHS:	DLD54_03385

LUU:	H4B44_06520

LPAI:

GYM71_03940

LXO:	KIM322_05490(tagE6)

LCA:	LSEI_0891 LSEI_0892

LCZ:	LCAZH_0834 LCAZH_0835

LCS:	LCBD_0986 LCBD_0987

LCE:	LC2W_0990 LC2W_0991

LCW:	BN194_09760 BN194_09770

LCL:	LOCK919_1036 LOCK919_1037

LPQ:	AF91_09450 AF91_09455

LPI:	LBPG_00061 LBPG_00062

LPAP:

LBPC_0831 LBPC_0832

LCB:	LCABL_10040(tagE2) LCABL_10050(tagE3)

LCX:	LCA12A_2180 LCA12A_2181

LRH:	LGG_00348(yohJ) LGG_00349(yohH) LGG_01586(yohH) LGG_01587(yohJ) LGG_02284 LGG_02285(yohH)

LRG:	LRHM_0335 LRHM_0336 LRHM_1523 LRHM_1524 LRHM_2195 LRHM_2196

LRL:	LC705_00333(yohJ) LC705_00334(yohH) LC705_01567(yohH) LC705_01568(yohJ) LC705_02275 LC705_02276(yohH)

LRA:	LRHK_1556 LRHK_1557 LRHK_2282 LRHK_2284 LRHK_343 LRHK_344

LRO:	LOCK900_0327 LOCK900_0328 LOCK900_1529 LOCK900_1530 LOCK900_2247 LOCK900_2248

LRC:	LOCK908_0339 LOCK908_0340 LOCK908_1622 LOCK908_1623 LOCK908_2339 LOCK908_2340

LCHI:

KG086_10015 KG086_10020

LZE:	KG087_05270 KG087_05290 KG087_05295 KG087_05340 KG087_10675 KG087_10680 KG087_11680 KG087_11745 KG087_11750

LHN:	LHUE1_000383 LHUE1_000384 LHUE1_000533 LHUE1_000541 LHUE1_000542 LHUE1_002141 LHUE1_002142 LHUE1_002144 LHUE1_002145 LHUE1_002155

LPL:	lp_1299(tagE1) lp_1311(tagE2) lp_1312(tagE3) lp_2498(tagE4) lp_2843(tagE5) lp_2844(tagE6)

LPJ:	JDM1_1099(tagE1) JDM1_1106(tagE2) JDM1_1107(tagE3) JDM1_2011(tagE4) JDM1_2280(tagE5) JDM1_2282(tagE6)

LPT:	zj316_1318(tagE1) zj316_1327(tagE2) zj316_1328(tagE3) zj316_2429(tagE4) zj316_2714(tagE5) zj316_2715(tagE6)

LPS:	LPST_C1052(tagE1) LPST_C1058(tagE2) LPST_C1059(tagE3) LPST_C2058(tagE4) LPST_C2332(tagE5) LPST_C2333(tagE6)

LPR:	LBP_cg0993 LBP_cg1001 LBP_cg1002 LBP_cg2051 LBP_cg2327 LBP_cg2328

LPZ:	Lp16_1003 Lp16_1009 Lp16_1010 Lp16_1984 Lp16_2241 Lp16_2242

LPB:	SH83_05445 SH83_05480 SH83_05485 SH83_10640 SH83_11975 SH83_11980

LPX:	ASU28_02740 ASU28_02745 ASU28_05175 ASU28_05205 ASU28_05210 ASU28_10670

LPG:	BB562_03595 BB562_03600 BB562_05205 BB562_10875 BB562_10880 BB562_10910

LARG:

LPA65_05215 LPA65_05245 LPA65_05250 LPA65_10895 LPA65_12295 LPA65_12300

LRE:	Lreu_0080 Lreu_0081 Lreu_1256

LRF:	LAR_0075 LAR_0076 LAR_1190

LRU:	HMPREF0538_21222 HMPREF0538_21223

LRT:	LRI_0088 LRI_0089 LRI_0710

LRR:	N134_00425 N134_00430 N134_07030

LFE:	LAF_0051 LAF_0052

LFR:	LC40_0037 LC40_0038

LFF:	LBFF_0052 LBFF_0053

LMU:	LBLM1_10605 LBLM1_10610

LOR:	AYI71_09165 AYI71_09170

LVA:	LV515_00355 LV515_00360 LV515_01785

LFN:	LF145_00305 LF145_00310 LF145_08220

LPON:

LP475_00320 LP475_00325

LGAS:

LG045_00255 LG045_00265

LPAS:

KZE55_01555 KZE55_01560 KZE55_06240 KZE55_06245(asp1) KZE55_09805

LPOR:

PRK60_07160 PRK60_09580(asp1) PRK60_09585

LNG:	BSQ50_10735

LHW:	BSQ49_04425

LLE:	AYR59_02420

LFV:	LF543_06835

FIX:	M8332_06290

FMT:	M3M35_04285

LBH:

Lbuc_2160

LBN:	LBUCD034_2263

LPAR:

FAM21731_00669 FAM21731_01238

LCU:	PL11_002040

LBR:	LVIS_1464 LVIS_1465

LBK:	LVISKB_1412 LVISKB_1413

LKO:	ABN16_11195 ABN16_11200 ABN16_11210

LZY:	LZ3411_0940 LZ3411_0941 LZ3411_2326

LSUA:

H3M12_02280 H3M12_07965 H3M12_07970

LNA:	RIN67_01110

LJI:	ELX58_01065 ELX58_01070

LSJ:

LSJ_0068

LAGL:

BEN83_09500 BEN83_09555

LFD:	QFX10_06120(asp1) QFX10_06125

LBT:	AYR52_00995 AYR52_01000 AYR52_09140 AYR52_09145 AYR52_10965

LCY:	LC20004_10685 LC20004_10690

LHO:	LOOC260_122100 LOOC260_122110

LOL:	LACOL_1656 LACOL_1657 LACOL_1677(gtfA)

LNN:	F0161_10380 F0161_10385 F0161_10770

LKU:	APS55_01670 APS55_01675

ABOM:

D7I45_00625 D7I45_00630 D7I45_05780 D7I45_05785

AAPN:

AAPFHON13_02200 AAPFHON13_02210

LMAE:

FGL90_04210 FGL90_04215

PPE:	PEPE_0067 PEPE_0224 PEPE_0225

PPEN:

T256_01240 T256_01245

PCE:	PECL_1756 PECL_1757 PECL_622 PECL_651 PECL_652

PDM:	ADU72_0665 ADU72_0666

PACI:

A4V11_03755 A4V11_07725 A4V11_07730

PIO:	PI20285_01215 PI20285_01220

LROS:

LROSL1_0030 LROSL1_0031 LROSL1_0321

LBM:	DS830_05475

LHB:	D1010_12080 D1010_12735

OOE:	OEOE_1300 OEOE_1301

OEN:	DSM07_09355 DSM07_09360

OSI:	DLJ48_00785 DLJ48_00790

LME:	LEUM_0010 LEUM_0011 LEUM_1923

LMM:	MI1_00050 MI1_00055 MI1_08390

LMK:	LMES_0010 LMES_0011 LMES_1677

LCI:	LCK_01447(yohH) LCK_01613

LKI:	LKI_06420 LKI_07900

LEC:	LGMK_04255 LGMK_05715

LCN:	C270_00675

LGS:	LEGAS_0544(gtfA) LEGAS_1748

LGE:	C269_02680 C269_08380

LLF:	BCR17_04555

LGC:	A9176_03090

LSU:	A6B45_00050 A6B45_00055 A6B45_09275

LPSE:

FGL85_02950 FGL85_03340 FGL85_06625 FGL85_06630

WKO:	WKK_04380 WKK_04385 WKK_06600

WCB:	AO080_01170 AO080_01175 AO080_04930 AO080_05885 AO080_11400 AO080_11415

WJO:	FOL01_0197 FOL01_0198 FOL01_0723

WPA:	CO680_07410 CO680_07415

WCF:	C6P13_02595 C6P13_07190 C6P13_09770 C6P13_09775

WSO:	WSWS_01431(tagE) WSWS_01432

WHE:	EFA59_00875 EFA59_00880 EFA59_03545

WDI:	H9L19_04375 H9L19_04380

WVR:	IE337_01355

WCO:	G7084_03370(gtfA) G7084_07825 G7084_07830

LBE:	MOO44_05035 MOO44_05040

XAK:	KIMC2_02510(tagE3)

XAP:	XA3_03600(tagE6)

EGA:	AL523_00415

ERAF:

J9537_16610

EIE:	ENLAB_08960(tagE)

VCP:	H9L18_03440

VHY:	G7082_02510

VIE:	OL234_05745

AUR:	HMPREF9243_0770(gtfA)

AUN:	AWM73_05830

ABAE:

CL176_06675

CBI:

CLJ_B2934

PXV:	FXF36_10330(gtfA)

ERE:	EUBREC_2507 EUBREC_2518

ERT:

EUR_26310

ERA:

ERE_07800

EBM:	SG0102_22120(gtf1)

SHI:	Shel_14750

LXL:	KDY119_02600(tagE)

MTS:	MTES_0795 MTES_0867

MIP:	AXH82_10855

MCW:	A8L33_06710

MPAL:

BO218_07765

MIH:	BJP65_05695 BJP65_06060

MLV:	CVS47_00551(tagE)

MWA:	E4K62_03535

MPRT:

ET475_02610

MSED:

E3O41_11015

MOY:	CVS54_01046(tagE)

MCAW:

F6J84_12080

MLZ:	F6J85_03400

MCHN:

HCR76_08745

MICS:

C1N74_03190

MBIN:

LXM64_12710

MLIQ:

NMQ05_05360

MPAO:

IZR02_04185

MNF:	JSY13_02420

MINV:

T9R20_13495

AGY:	ATC03_02345

AGM:	DCE93_01760

ASOI:

MTP13_01990

MALK:

MalAC0309_0118

MDB:	OVN18_04365

MYL:	C3E77_03680 C3E77_03690

GRY:	D7I44_17720

PLAP:

EAO79_11330

ARM:

ART_1251

ACRY:

AC20117_19715

AAGI:

NCTC2676_1_01717(tagE_1) NCTC2676_1_01725(tagE_3)

AJG:	KKR91_11360

ASUF:

MNQ99_09150

AAI:	AARI_14980

PAEY:

KUF55_10290 KUF55_10370

XCE:

Xcel_2591

IDO:	I598_3339(tagE_1) I598_3340(tagE_2)

SERJ:

SGUI_1312

BLY:	A2T55_13875

BLIN:

BLSMQ_2862 BLSMQ_3087

BLUT:

EW640_07370

BCAU:

I6G59_00195

NPS:	KRR39_17420

MUZ:	H4N58_17610

LSK:	J5X98_21805

RBA:

RB2471

» show all

Reference

1 [PMID:14245359]

Authors

GLASER L, BURGER MM.

Title

THE SYNTHESIS OF TEICHOIC ACIDS. 3. GLUCOSYLATION OF POLYGLYCEROPHOSPHATE.

Journal

J Biol Chem 239:3187-91 (1964)

Reference

2 [PMID:21558268]

Authors

Allison SE, D'Elia MA, Arar S, Monteiro MA, Brown ED

Title

Studies of the genetics, function, and kinetic mechanism of TagE, the wall teichoic acid glycosyltransferase in Bacillus subtilis 168.

Journal

J Biol Chem 286:23708-16 (2011)
DOI:10.1074/jbc.M111.241265

Sequence

[bsu:BSU35730]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.52

IUBMB Enzyme Nomenclature:

2.4.1.52

ExPASy - ENZYME nomenclature database:

2.4.1.52

BRENDA, the Enzyme Database:

2.4.1.52

CAS:	37277-60-4

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