KEGG ENZYME: 2.4.1.66

ENZYME: 2.4.1.66

Entry

EC 2.4.1.66                 Enzyme

Name

procollagen glucosyltransferase;
galactosylhydroxylysine glucosyltransferase;
collagen glucosyltransferase;
collagen hydroxylysyl glucosyltransferase;
galactosylhydroxylysyl glucosyltransferase;
UDP-glucose-collagenglucosyltransferase;
uridine diphosphoglucose-collagen glucosyltransferase;
UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase;
UDP-glucose:(2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen] D-glucosyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-glucose:[procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine 2-alpha-D-glucosyltransferase (configuration-retaining)

Reaction(IUBMB)

UDP-alpha-D-glucose + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine = UDP + [procollagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine [RN:R04491]

Reaction(KEGG)

R04491

Substrate

UDP-alpha-D-glucose [CPD:C00029];
[procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine

Product

UDP [CPD:C00015];
[procollagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine

Comment

Involved in the synthesis of carbohydrate units in the complement system (cf. EC 2.4.1.50 procollagen galactosyltransferase).

History

EC 2.4.1.66 created 1972

Pathway

ec00514

Other types of O-glycan biosynthesis

Orthology

K13646

lysyl hydroxylase/galactosyltransferase/glucosyltransferase

Genes

HSA:	8985(PLOD3)

PTR:	463618(PLOD3)

PPS:	100968399(PLOD3)

GGO:	101151570(PLOD3)

PON:	100189797(PLOD3)

NLE:	100597272(PLOD3)

HMH:	116810964(PLOD3)

MCC:	714283(PLOD3)

MCF:	101867014(PLOD3)

MTHB:

126950346

MNI:	105492738(PLOD3)

CSAB:

103246688(PLOD3)

CATY:

105593407(PLOD3)

PANU:

101020298(PLOD3)

TGE:	112620036(PLOD3)

MLEU:

105543347(PLOD3)

RRO:	104681188(PLOD3)

RBB:	108518931(PLOD3)

TFN:	117072346(PLOD3)

PTEH:

111527915(PLOD3)

CANG:

105524674(PLOD3)

CJC:	100390092(PLOD3)

SBQ:	101043341(PLOD3)

CIMI:

108307954(PLOD3)

MMUR:

105868206 105874704

LCAT:

123632023(PLOD3)

PCOQ:

105826035(PLOD3)

OGA:	100962184(PLOD3)

MMU:	26433(Plod3)

MCAL:

110294972(Plod3)

MPAH:

110339077(Plod3)

RNO:	288583(Plod3)

MCOC:

116068572(Plod3)

ANU:	117697873(Plod3)

MUN:	110566258(Plod3)

MAUA:

106021964(Plod3)

PROB:

127236975(Plod3)

PLEU:

114710313(Plod3)

MORG:

121446082(Plod3)

MFOT:

126491910

AAMP:

119824992(Plod3)

NGI:	103733492(Plod3)

HGL:	101701075(Plod3)

CPOC:

100733225(Plod3)

CCAN:

109692822(Plod3)

DORD:

105997327(Plod3)

DSP:	122113534(Plod3)

PLOP:

125367859(Plod3)

NCAR:

124970077

MMMA:

107146598(Plod3)

OCU:

103345704

OPI:	101533570(PLOD3)

TUP:	102476916(PLOD3)

GVR:	103604904(PLOD3)

CFA:	479730(PLOD3)

CLUD:

112646206(PLOD3)

VVP:	112935697(PLOD3)

VLG:	121487921(PLOD3)

NPO:	129520270(PLOD3)

AML:	100484476(PLOD3)

UMR:	103670197(PLOD3)

UAH:	113267834(PLOD3)

UAR:	123777278(PLOD3)

ELK:

111146121

LLV:

125090429

MPUF:

101679995(PLOD3)

MNP:	132026581(PLOD3)

MLK:	131819146(PLOD3)

NVS:	122895290(PLOD3)

ORO:	101383290(PLOD3)

EJU:	114214465(PLOD3)

ZCA:	113933351(PLOD3)

MLX:	117999442(PLOD3)

NSU:	110589725(PLOD3)

LWW:	102736053(PLOD3)

FCA:	101089668(PLOD3)

PYU:	121017669(PLOD3)

PBG:	122471319(PLOD3)

PVIV:

125154551(PLOD3)

LRUF:

124519191

PTG:	102950927(PLOD3)

PPAD:

109250535(PLOD3)

PUC:

125928208

AJU:

106988106

HHV:	120239329(PLOD3)

BTA:	514996(PLOD3)

BOM:	102276636(PLOD3)

BIU:	109578633(PLOD3)

BBUB:

102415837(PLOD3)

BBIS:

104998970(PLOD3)

CHX:	100861039(PLOD3)

OAS:	101121738(PLOD3)

BTAX:

128062470(PLOD3)

ODA:	120878960(PLOD3)

CCAD:

122433016(PLOD3)

MBEZ:

129545655(PLOD3)

SSC:	100624420(PLOD3)

CFR:	102505707(PLOD3)

CBAI:

105067244(PLOD3)

CDK:	105092397(PLOD3)

VPC:	102527284(PLOD3)

BACU:

103018042(PLOD3)

BMUS:

118881352(PLOD3)

LVE:	103090807(PLOD3)

OOR:	101272678(PLOD3)

DLE:	111181992(PLOD3)

PCAD:

102994038(PLOD3)

PSIU:

116739866(PLOD3)

NASI:

112399927(PLOD3)

ECB:	100059479(PLOD3)

EPZ:	103566973(PLOD3)

EAI:	106839342(PLOD3)

MYB:	102249872(PLOD3)

MYD:	102755224(PLOD3)

MMYO:

118656360(PLOD3)

MLF:	102417167(PLOD3)

PKL:	118703384(PLOD3)

EFUS:

103286244(PLOD3)

MNA:	107526507(PLOD3)

DRO:	112314858(PLOD3)

SHON:

118992841(PLOD3)

AJM:	119044717(PLOD3)

PDIC:

114500553(PLOD3)

PHAS:

123806488(PLOD3)

MMF:	118641652(PLOD3)

PPAM:

129083802(PLOD3)

HAI:	109385048(PLOD3)

RFQ:	117024816(PLOD3)

PALE:

102879015(PLOD3)

PGIG:

120591731(PLOD3)

PVP:	105299719(PLOD3)

RAY:	107511774(PLOD3)

MJV:	108395755(PLOD3)

TOD:	119241561(PLOD3)

SARA:

101558289(PLOD3)

SETR:

126029561(PLOD3)

LAV:	100675876(PLOD3)

TMU:

101349481

ETF:	101640056(PLOD3)

DNM:	101416474(PLOD3)

MDO:	100017782(PLOD3)

GAS:	123244749(PLOD3)

SHR:	100921874(PLOD3)

AFZ:

127560952

PCW:	110194378(PLOD3)

OAA:	100086224(PLOD3)

OMA:

130263335

AGEN:

126034626

ASN:

102379166

AMJ:	102561107(PLOD3)

PSS:	102444474(PLOD3)

CCAY:

125628614(PLOD3)

DCC:	119849255(PLOD3)

CPIC:

101943910(PLOD3)

MRV:	120381391(PLOD3)

ACS:	100558042(plod3)

ASAO:

132777682(PLOD3)

PVT:	110087641(PLOD3)

SUND:

121933382(PLOD3)

PBI:	103051832(PLOD3)

PMUR:

107291310(PLOD3)

CTIG:

120301057(PLOD3)

PGUT:

117679687(PLOD3)

APRI:

131197737(PLOD3)

PTEX:

113449472(PLOD3)

NSS:	113422790(PLOD3)

VKO:	123018930(PLOD3)

PMUA:

114581701(PLOD3)

PRAF:

128399618(PLOD3)

ZVI:	118094932(PLOD3)

HCG:	128331910(PLOD3)

GJA:	107118151(PLOD3)

STOW:

125444847(PLOD3)

EMC:	129339034(PLOD3)

XLA:	380138(plod3.L) 495489

XTR:	734090(plod3)

NPR:	108800474(PLOD3)

RTEM:

120933651(PLOD3)

BBUF:

120990542

MUO:	115456999(PLOD3)

GSH:	117350186(PLOD3)

DRE:	556077(plod3)

SRX:	107709211 107737962

SANH:

107673154 107676175

SGH:	107567109 107575731

CAUA:

113041328(plod3)

CGIB:

128011419

PTET:

122334528(plod3) 122334587

LROH:

127154944(plod3)

OMC:	131531651(plod3)

PPRM:

120463468(plod3)

RKG:	130069421(plod3)

MAMB:

125260123(plod3)

CIDE:

127505558

MASI:

127419328 127419824

TROS:

130544911(plod3)

TDW:	130409310(plod3)

MANU:

129430632(plod3)

IPU:

108275691

IFU:	128619223(plod3)

PHYP:

113525458

SMEO:

124398795(plod3)

TFD:	113646092(plod3)

TVC:	132862771(plod3)

AMEX:

103037645

CMAO:

118799343(plod3)

EEE:

113568782

CHAR:

105891472(plod3)

TRU:	100101242(plod3)

TFS:	130523051(plod3)

TNG:	GSTEN00003803G001

TBEN:

117480844(plod3)

EMAC:

134875696(plod3)

ELY:	117245834(plod3)

EFO:	125883736(plod3)

PLEP:

121965451(plod3)

SLUC:

116065859(plod3)

PFLV:

114574041(plod3)

GAT:	120822297(plod3)

PPUG:

119221736(plod3)

AFB:	129093099(plod3)

CLUM:

117748197(plod3)

PSWI:

130212044(plod3)

MSAM:

119912035 119912612(plod3)

SCHU:

122870115(plod3)

CUD:	121504490(plod3)

ALAT:

119026698(plod3)

MZE:

101473400

ONL:

100697420

OAU:	116334646(plod3)

OLA:	101154842(plod3)

OML:	112141494(plod3)

CSAI:

133420117(plod3)

XMA:

102223949

XHE:	116732017(plod3)

PFOR:

103129610

PLAI:

106958328(plod3)

PMEI:

106904637(plod3)

GAF:	122820891(plod3)

PPRL:

129376666

CVG:	107102307(plod3)

CTUL:

119774676(plod3)

GMU:	124880767(plod3)

KMR:	108229421(plod3)

ALIM:

106511660

NWH:	119410195(plod3)

AOCE:

111567088(plod3)

MCEP:

125008878(plod3)

CSEM:

103389255

POV:	109643399(plod3)

SSEN:

122767094(plod3)

HHIP:

117751848(plod3)

HSP:	118102891(plod3)

SMAU:

118319902(plod3)

LCF:	108892696 108892807

SDU:

111239991

SLAL:

111647817

XGL:	120797240(plod3)

HCQ:	109518414(plod3)

SSCV:

125992156

SBIA:

133494654(plod3)

PEE:	133398097(plod3)

PTAO:

133472377(plod3)

BPEC:

110174873

MALB:

109952454(plod3)

BSPL:

114851242(plod3)

SJO:	128384062(plod3)

SASA:

100196315(plod3)

STRU:

115183238(plod3)

OTW:	112235044 121847355

OMY:	110532881(plod3)

OGO:

124008310

OKI:

109886259

OKE:	118381469(plod3)

CCLU:

121557767(plod3)

ELS:

105008588

SFM:	108920367 108923182

PKI:	111835052 111860867

AANG:

118223708(plod3)

LOC:

102685790

PSPA:

121305608 121306609

ARUT:

117404435 117967929

PSEX:

120525067(plod3)

LCM:	102347396(PLOD3)

CPLA:

122544351

HOC:	132835223(plod3)

PMRN:

116939825

LRJ:

133350383

BBEL:

109469521

CIN:

100178986

SCLV:

120344031

LPIC:

129276874

FEX:

115245513

TPRE:

106655232

LHT:

122507079

LBD:

127287438

FAS:

105272692

DAM:

107042269

AGIF:

122848610

VCAN:

122413664

CCIN:

107263621

DSM:

124409192

NPT:

124216834

NFB:

124180228

NVG:

124302731

AROA:

105689017

AGB:

108915013

LDC:

111517758

APLN:

108733015

OTU:

111417207

DCI:

103506550

HVI:

124360674

MQU:	128991601 128992403

FOC:

113206291

TPAL:

117640830

SGRE:

126295284

IEL:

124164305

DPZ:

124320936

PJA:	122246560 122260753 122262496

PCHN:

125036057 125041711 125042482

PMOO:

119581816 119594377

HAME:

121857217 121863340 121868820

PCLA:

123759111 123759160 123760181 123768393

CQD:	128684105 128689496

PTRU:

123512406 123519830

ESN:

127009504

HAZT:

108679845

TCF:

131885193

PPOI:

119096284 119096383

DSV:

119446574

RSAN:

119389743

RMP:

119177002

VDE:

111244671

VJA:

111260478

DFR:

124490505

UDV:

129234119

SDM:	118192558 118196474

LPOL:

106474399

PMEO:

129586199

TSP:

Tsp_03029

HRO:	HELRODRAFT_185714

PVUL:

126828860

BGT:

106067603

GAE:

121390029

HRF:

124110780

HRJ:

124279706

CRG:

105335547

CVN:

111137017

CANU:

128189035

OED:

125679627

PMAX:

117344468

MCAF:

127719443 127719449

MMER:

123527641

RPHI:

132724076 132737997 132738885

DPOL:

127832507

OBI:

106878123

OSN:

115209243

NVE:

5513198

EPA:

110241798

ATEN:

116302656

ADF:

107346845

AMIL:

114959945

PDAM:

113682513

SPIS:

111329220

DGT:

114518278

XEN:

124443869

HSY:	130656162 130656165

SRE:	PTSG_00122

» show all

Reference

1 [PMID:5637038]

Authors

Bosmann HB, Eylar EH.

Title

Attachment of carbohydrate to collagen. Isolation, purification and properties of the glucosyl transferase.

Journal

Biochem Biophys Res Commun 30:89-94 (1968)
DOI:10.1016/0006-291X(68)90717-1

Reference

2 [PMID:4968368]

Authors

Bosmann HB, Eylar EH.

Title

Collagen-glucosyl transferase in fibriblasts transformed by oncogenic viruses.

Journal

Nature 218:582-3 (1968)
DOI:10.1038/218582a0

Reference

3 [PMID:4288358]

Authors

Butler WT, Cunningham LW.

Title

Evidence for the linkage of a disaccharide to hydroxylysine in tropocollagen.

Journal

J Biol Chem 241:3882-8 (1966)

Reference

Authors

Kivirikko, K.I. and Myllyla, R.

Title

In: Hall, D.A. and Jackson, D.S. (Eds.), International Review of Connective Tissue Research, vol. 8, Academic Press, New York, 1979, p. 23.

Reference

5 [PMID:21220425]

Authors

Sricholpech M, Perdivara I, Nagaoka H, Yokoyama M, Tomer KB, Yamauchi M

Title

Lysyl hydroxylase 3 glucosylates galactosylhydroxylysine residues in type I collagen in osteoblast culture.

Journal

J Biol Chem 286:8846-56 (2011)
DOI:10.1074/jbc.M110.178509

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.66

IUBMB Enzyme Nomenclature:

2.4.1.66

ExPASy - ENZYME nomenclature database:

2.4.1.66

BRENDA, the Enzyme Database:

2.4.1.66

CAS:

9028-08-4

DBGET integrated database retrieval system