KEGG ENZYME: 2.4.2.37

ENZYME: 2.4.2.37

Entry

EC 2.4.2.37                 Enzyme

Name

NAD+---dinitrogen-reductase ADP-D-ribosyltransferase;
NAD-azoferredoxin (ADPribose)transferase;
NAD-dinitrogen-reductase ADP-D-ribosyltransferase;
draT (gene name)

Class

Transferases;
Glycosyltransferases;
Pentosyltransferases

Sysname

NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase

Reaction(IUBMB)

NAD+ + [dinitrogen reductase]-L-arginine = nicotinamide + [dinitrogen reductase]-Nomega-alpha-(ADP-D-ribosyl)-L-arginine [RN:R03447]

Reaction(KEGG)

R03447

Substrate

NAD+ [CPD:C00003];
[dinitrogen reductase]-L-arginine [CPD:C03315]

Product

nicotinamide [CPD:C00153];
[dinitrogen reductase]-Nomega-alpha-(ADP-D-ribosyl)-L-arginine [CPD:C01253]

Comment

The combined action of this enzyme and EC 3.2.2.24, ADP-ribosyl-[dinitrogen reductase] hydrolase, controls the activity level of nitrogenase (EC 1.18.6.1). In the presence of ammonium, the product of nitrogenase, this enzyme covalently links an ADP-ribose moiety to a specific arginine residue of the dinitrogenase reductase component of nitrogenase, blocking its activity.

History

EC 2.4.2.37 created 1992, modified 2015

Orthology

K05951

NAD+---dinitrogen-reductase ADP-D-ribosyltransferase

Genes

VZI:	G5S32_16000

SAVI:

JYB87_03995

TTU:	TERTU_0343

MCA:

MCA1828

MMEO:

OOT43_04630

MMT:	Metme_3770

MDN:	JT25_015365

MDH:	AYM39_06045

MKO:	MKLM6_1231

METL:

U737_04950

MPAD:

KEF85_02880

MELL:

IVG45_20700

MMOT:

QZJ86_06380

MBUR:

EQU24_17285

MMAI:

sS8_5461

MSZE:

MSZNOR_4721(draT)

THIS:

HZT40_12980

TUN:	J9260_09895

TLO:	J9253_07000

TSB:	HMY34_13380

ALV:	Alvin_1882

TVI:	Thivi_3646

TMB:	Thimo_3246

MPUR:

MARPU_03075

TSY:	THSYN_08890

TTP:	E6P07_09460

THIP:

N838_09325

CJAP:

GWK36_11820

THIM:

KFB96_12290

TBOG:

LT988_07965

TLR:	Thiosp_00980(draT)

TFRI:

Thiofri_01194(draT)

TWG:	Thiowin_00052(draT)

EBS:	ECTOBSL9_3099

AAEO:

BJI67_04195

HAZ:	A9404_01635

SEDS:

AAY24_16610

NIK:	F5I99_03435

GSN:	YC6258_05525

TAU:

Tola_0578

VFF:	VITFI_CDS1675

AQL:	BXU06_13135

RAC:	RA876_02730

HTN:	KI616_08025

RGE:	RGE_42860(draT)

RBN:	RBXJA2T_11478

IDC:	LRM40_03680

NPV:	OHM77_01940

SLT:

Slit_0880

FAM:	OYT1_ch0970

FKU:	FGKAn22_10690

SEME:

MIZ01_0822

SLAC:

SKTS_09630

DSU:

Dsui_0954

ARES:

IWH25_06470

AIQ:	Azoinq_06065

NIV:	JY500_11650

RBH:	B4966_06750

DAR:

Daro_1416

DEY:	HYN24_06715

DDEN:

KI615_08645

QAU:	KI612_04820

FLE:	KI610_08730

AZO:	azo0537(draT)

AOA:

dqs_0547

AZA:	AZKH_0793(draT)

AZI:	AzCIB_0708

AZD:	CDA09_23075

AZR:	CJ010_03555

AZQ:	G3580_19055

ACOM:

CEW83_10480

ZPA:	C3497_06315

APP:	CAP2UW1_4446

BRO:	BRAD285_0319(draT)

RPA:	TX73_007350 TX73_012435

RPB:

RPB_3044

RPC:

RPC_0878

RPD:

RPD_2407

RPE:	RPE_0837 RPE_3888

RPT:	Rpal_1616 Rpal_2657

RPX:	Rpdx1_3108 Rpdx1_3129

BVR:

BVIR_1911

BLAG:

BLTE_24170

RSQ:	Rsph17025_3203

CAZT:

LV780_15490

RCP:	RCAP_rcc03016(draT)

RBL:	B6K69_09400

RHC:

RGUI_1803

RAP:	RHOA_4114(draT)

AZL:	AZL_007730

ALI:	AZOLI_0684(draT)

ABS:	AZOBR_70132(draT)

ABQ:	ABAZ39_09990

ABF:	AMK58_04670

ATI:	AL072_00470

AHU:	A6A40_02920

AZT:	TSH58p_07625

AZM:	DM194_02570

AOZ:	HUE56_19880

AARE:

D3093_13670

AZS:	E6C72_07860

SKT:	IGS68_09240

SROE:

JL101_016830

RRU:	Rru_A1009 Rru_A1389

RRF:	F11_05200 F11_07175

RPM:	RSPPHO_00485 RSPPHO_02585(draT)

MGY:	MGMSRv2__0346(draT)

MGRY:

MSR1_18690(draT)

MAGX:

XM1_3937(draT)

MAGN:

WV31_08655

DEX:	HWD60_15140

DVN:	HQ394_18640

MAG:

amb1575

VSU:	P3M64_06885

MGM:

Mmc1_1203

AFR:	AFE_1524(draT)

AFE:	Lferr_1242

AFI:	Acife_1652

AFJ:	AFERRID_23440

AFP:	K1Y48_11505

GSU:	GSU2802(draT)

GSK:	KN400_2739(draT)

GME:	Gmet_0674(draT)

GPI:	GPICK_13000

GBZ:	JZM60_09030

GEM:

GM21_2137

GEB:

GM18_1869

GEF:	FO488_17125

GUR:

Gura_1205

GEO:	Geob_2585(draT)

GLO:

Glov_0630

TAMM:

GEAMG1_0065(draT)

GBM:	Gbem_2081(draT)

GBN:	GEOBRER4_11380(draT)

GER:	KP004_09400

GSUB:

KP001_05785

GNT:	KP003_08810

GPL:	M1B72_11370

GHC:	L9S41_01355

PCA:	Pcar_2092(draT)

PACE:

A6070_04835

PEF:	A7E78_00750

PPD:

Ppro_3487

DEU:

DBW_0108

DVE:	DESUT3_36230(draT)

DEP:	AOP6_2674(draT)

DES:	DSOUD_2576(draT)

DAT:	HRM2_09830(draT)

DOV:	DSCO28_58820(draT)

AFW:	Anae109_3033

ANK:	AnaeK_3210

AORY:

AMOR_48930(draT)

APAU:

AMPC_39510(draT)

OBT:	OPIT5_01825

CAA:

Caka_2843

RUFI:

K0V07_13855

DIN:	Selin_0259

DAP:	Dacet_1042

GTL:	EP073_09665

CNI:	Calni_0683

» show all

Reference

1 [PMID:3141411]

Authors

Lowery RG, Ludden PW.

Title

Purification and properties of dinitrogenase reductase ADP-ribosyltransferase from the photosynthetic bacterium Rhodospirillum rubrum.

Journal

J Biol Chem 263:16714-9 (1988)

Reference

2 [PMID:2506427]

Authors

Fitzmaurice WP, Saari LL, Lowery RG, Ludden PW, Roberts GP

Title

Genes coding for the reversible ADP-ribosylation system of dinitrogenase reductase from Rhodospirillum rubrum.

Journal

Mol Gen Genet 218:340-7 (1989)
DOI:10.1007/BF00331287

Sequence

[rru:Rru_A1009]

Reference

3 [PMID:24934999]

Authors

Moure VR, Costa FF, Cruz LM, Pedrosa FO, Souza EM, Li XD, Winkler F, Huergo LF

Title

Regulation of nitrogenase by reversible mono-ADP-ribosylation.

Journal

Curr Top Microbiol Immunol 384:89-106 (2015)
DOI:10.1007/82_2014_380

Other DBs

ExplorEnz - The Enzyme Database:

2.4.2.37

IUBMB Enzyme Nomenclature:

2.4.2.37

ExPASy - ENZYME nomenclature database:

2.4.2.37

BRENDA, the Enzyme Database:

2.4.2.37

CAS:	117590-45-1

DBGET integrated database retrieval system