KEGG ENZYME: 2.4.2.49

ENZYME: 2.4.2.49

Entry

EC 2.4.2.49                 Enzyme

Name

neamine phosphoribosyltransferase;
btrL (gene name);
neoM (gene name)

Class

Transferases;
Glycosyltransferases;
Pentosyltransferases

Sysname

neamine:5-phospho-alpha-D-ribose 1-diphosphate phosphoribosyltransferase

Reaction(IUBMB)

neamine + 5-phospho-alpha-D-ribose 1-diphosphate = 5''-phosphoribostamycin + diphosphate [RN:R08898]

Reaction(KEGG)

R08898

Substrate

neamine [CPD:C01441];
5-phospho-alpha-D-ribose 1-diphosphate [CPD:C00119]

Product

5''-phosphoribostamycin [CPD:C18004];
diphosphate [CPD:C00013]

Comment

Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. The enzyme requires a divalent metal ion, optimally Mg2+, Ni2+ or Co2+.

History

EC 2.4.2.49 created 2013

Pathway

ec00524

Neomycin, kanamycin and gentamicin biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K13554

neamine phosphoribosyltransferase

Genes

PCHI:

PC41400_18575

SRN:	A4G23_05118(btrL)

SFB:	CP974_27315

Reference

1 [PMID:17482823]

Authors

Kudo F, Fujii T, Kinoshita S, Eguchi T

Title

Unique O-ribosylation in the biosynthesis of butirosin.

Journal

Bioorg Med Chem 15:4360-8 (2007)
DOI:10.1016/j.bmc.2007.04.040

Sequence

[ag:BAE07064]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.2.49

IUBMB Enzyme Nomenclature:

2.4.2.49

ExPASy - ENZYME nomenclature database:

2.4.2.49

BRENDA, the Enzyme Database:

2.4.2.49

DBGET integrated database retrieval system