KEGG ENZYME: 2.4.2.57

ENZYME: 2.4.2.57

Entry

EC 2.4.2.57                 Enzyme

Name

AMP phosphorylase;
AMPpase;
nucleoside monophosphate phosphorylase;
deoA (gene name)

Class

Transferases;
Glycosyltransferases;
Pentosyltransferases

Sysname

AMP:phosphate alpha-D-ribosyl 5'-phosphate-transferase

Reaction(IUBMB)

(1) AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate [RN:R10836];
(2) CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate [RN:R10837];
(3) UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate [RN:R10838]

Reaction(KEGG)

R10836 R10837 R10838

Substrate

AMP [CPD:C00020];
phosphate [CPD:C00009];
CMP [CPD:C00055];
UMP [CPD:C00105]

Product

adenine [CPD:C00147];
alpha-D-ribose 1,5-bisphosphate [CPD:C01151];
cytosine [CPD:C00380];
uracil [CPD:C00106]

Comment

The enzyme from archaea is involved in AMP metabolism and CO2 fixation through type III RubisCO enzymes. The activity with CMP and UMP requires activation by cAMP [2].

History

EC 2.4.2.57 created 2014

Pathway

ec00230

Purine metabolism

ec00240

Pyrimidine metabolism

ec01100

Metabolic pathways

Orthology

K18931

AMP phosphorylase

Genes

SRB:	P148_SR1C001G0223

MJA:

MJ_0667

MFE:	Mefer_1403

MVU:	Metvu_0291

MFS:	MFS40622_1516

MIF:	Metin_0751

MJH:	JH146_1232

MESG:

MLAUSG7_0441

MESA:

MLASG1_0067

MIG:	Metig_0832

MMP:	MMP0327(deoA)

MMQ:	MmarC5_1346

MMX:	MmarC6_0624

MMZ:	MmarC7_1329

MMD:

GYY_01685

MMAK:

MMKA1_03350(deoA)

MMAO:

MMOS7_03620(deoA)

MMAD:

MMJJ_07310(pdp)

MAE:

Maeo_0618

MVN:	Mevan_1338

MVO:

Mvol_1718

MOK:	Metok_1244

METF:

CFE53_03450

AFU:	AF_1341 AF_1342

AFG:	AFULGI_00014530 AFULGI_00014540

APO:	Arcpr_1123

AVE:	Arcve_0240 Arcve_2095

AST:	Asulf_01770 Asulf_01771

FPL:

Ferp_0811

GAC:

GACE_0123

GAH:

GAH_00259

PFU:

PF1607

PFI:

PFC_10580

PHO:	PH1598(PH1598)

PAB:

PAB1982

PYN:

PNA2_0183

PYA:	PYCH_04830

PYS:

Py04_1485

PYC:	TQ32_08875

TKO:

TK0352

TON:

TON_1062

TGA:

TGAM_1786

TSI:

TSIB_0680

TBA:	TERMP_01023

THE:

GQS_10255

THA:

TAM4_270

THM:

CL1_1626

TLT:

OCC_02747

THS:

TES1_1098

TNU:

BD01_1010

TEU:

TEU_10940

TGY:	X802_02315

THV:	ADU37_CDS06780

TCH:	CHITON_1834

TPEP:

A0127_02550

TPIE:

A7C91_00800

TGG:	A3K92_01245

TCE:	A3L02_05060

TBS:	A3L01_06040

THH:	CDI07_05995

TSL:	A3L11_10085

TTD:	A3L14_08440

TPRF:

A3L09_03120

TRL:	A3L10_00560

TPAF:

A3L08_09185

THY:	A3L12_06725

TIC:	FH039_07700

TCQ:	TIRI35C_1520

THEM:

FPV09_01725

THEI:

K1720_06545

PPAC:

PAP_04670

MBA:	Mbar_A3188

MBY:	MSBRM_2287

MBW:	MSBRW_1549

MBAR:

MSBR2_0125

MBAK:

MSBR3_0180

MAC:	MA_3242(deoA)

MMA:

MM_0087

MMAZ:

MmTuc01_0096

MMJ:	MSMAS_1243

MMAC:

MSMAC_2591

MVC:	MSVAZ_1622

MEK:	MSKOL_1551

MLS:	MSLAZ_1586

METM:

MSMTP_1230

MEF:	MSWH1_2026

MEQ:	MSWHS_3043

MSJ:	MSSAC_1182

MSZ:	MSSIH_2777

MSW:	MSSIT_2809

MTHR:

MSTHT_0154

MTHE:

MSTHC_0574

MHOR:

MSHOH_2091

MFZ:	AOB57_001685

MBU:

Mbur_0255

MMET:

MCMEM_0874

MELO:

J7W08_02610

MMH:

Mmah_1278

MHAZ:

BHR79_07150

MPOT:

BKM01_03400

MEV:	Metev_0684

MZH:	Mzhil_0675

MPY:

Mpsy_0111

MZI:	HWN40_05870

MMAV:

RE476_02540

MSEB:

RE474_12380

MHZ:	Metho_1154

MTP:

Mthe_0462

MCJ:

MCON_0583

MHI:	Mhar_0827 Mhar_1625

MHU:

Mhun_2262

MRTJ:

KHC33_15725

MLA:

Mlab_0067

MEM:	Memar_0551

MBG:	BN140_1665(deoA)

MEMA:

MMAB1_2139

MCHK:

MchiMG62_06790

MSUM:

OH143_09480

MRC:	R6Y96_00015

MPI:

Mpet_0506

MEND:

L6E24_05320

MEFW:

F1737_08660

MAQE:

RJ40_06415

MFK:	E2N92_06550

MOU:	OU421_03255

MESB:

L1S32_06860

MANQ:

L1994_08825

MBN:

Mboo_0523

MFO:	Metfor_2665

MPL:

Mpal_2125

MPD:

MCP_0060

MEZ:	Mtc_0258(deoA)

RCI:	RCIX1126(deoA)

HARA:

AArcS_1364(deoA)

NPH:	NP_3958A(deoA)

HALI:

BV210_04495

SSAI:

N0B31_08630

HVO:	HVO_0965(deoA)

HME:	HFX_0962(deoA)

HGI:	ABY42_04630

HALE:

G3A49_04810

HLS:	KU306_09415

HLN:	SVXHx_0918(ampp)

HBO:	Hbor_21600

HLM:	DV707_15785

SRUB:

C2R22_06165

HDF:	AArcSl_0205(deoA)

NMG:	Nmag_4015(deoA)

NAJ:	B1756_15370

NAG:	AArcMg_2615

NAN:	AArc1_1083

NARA:

QQ977_06435

NBG:	DV706_02185

NAS:	GCU68_11445

MEAM:

MU439_00575

MEAE:

QEN48_02095

TAR:	TALC_00201

MAX:	MMALV_01880

MER:	MMINT_17690

MEAR:

Mpt1_c12740

MEUZ:

KRP56_01055

MARC:

AR505_0705 AR505_1641

ABI:

Aboo_0332

ACF:	AciM339_0725

SHC:	Shell_0989

DKA:

DKAM_0158

DFD:	Desfe_0233

DMU:	Desmu_0291

TAG:

Tagg_0379

THG:	TCELL_1247

HBU:

Hbut_0381

PDL:	Pyrde_2037

PABI:

PABY_20650

PARE:

PYJP_20540

TPE:

Tpen_0093

THB:	N186_01385

TCB:	TCARB_1361

THEL:

IG193_07085

NUE:	C5F50_03375

NIU:	DSQ19_01120

NCK:	QVH35_04710

BARC:

AOA65_1927

FLT:	Sv326_0528

LOB:	NEF87_004614 NEF87_004615

PSYT:

DSAG12_02244

AGW:	QT03_C0001G0516

» show all

Reference

1 [PMID:17303759]

Authors

Sato T, Atomi H, Imanaka T

Title

Archaeal type III RuBisCOs function in a pathway for AMP metabolism.

Journal

Science 315:1003-6 (2007)
DOI:10.1126/science.1135999

Sequence

[tko:TK0352]

Reference

2 [PMID:23065974]

Authors

Aono R, Sato T, Yano A, Yoshida S, Nishitani Y, Miki K, Imanaka T, Atomi H

Title

Enzymatic characterization of AMP phosphorylase and ribose-1,5-bisphosphate isomerase functioning in an archaeal AMP metabolic pathway.

Journal

J Bacteriol 194:6847-55 (2012)
DOI:10.1128/JB.01335-12

Sequence

[tko:TK0352]

Reference

3 [PMID:23659790]

Authors

Nishitani Y, Aono R, Nakamura A, Sato T, Atomi H, Imanaka T, Miki K

Title

Structure analysis of archaeal AMP phosphorylase reveals two unique modes of dimerization.

Journal

J Mol Biol 425:2709-21 (2013)
DOI:10.1016/j.jmb.2013.04.026

Sequence

[tko:TK0352]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.2.57

IUBMB Enzyme Nomenclature:

2.4.2.57

ExPASy - ENZYME nomenclature database:

2.4.2.57

BRENDA, the Enzyme Database:

2.4.2.57

DBGET integrated database retrieval system