KEGG ENZYME: 2.4.2.62

ENZYME: 2.4.2.62

Entry

EC 2.4.2.62                 Enzyme

Name

xylosyl alpha-1,3-xylosyltransferase;
XXYLT1 (gene name)

Class

Transferases;
Glycosyltransferases;
Pentosyltransferases

Sysname

UDP-alpha-D-xylose:[EGF-like domain protein]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine 3-alpha-D-xylosyltransferase (configuration-retaining)

Reaction(IUBMB)

UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine = UDP + [protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine [RN:R12637]

Reaction(KEGG)

R12637(G)

Substrate

UDP-alpha-D-xylose [CPD:C00190];
[protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine

Product

UDP [CPD:C00015];
[protein with EGF-like domain]-3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-serine

Comment

The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.

History

EC 2.4.2.62 created 2020

Pathway

ec00514

Other types of O-glycan biosynthesis

Orthology

K23800

xylosyl alpha-1,3-xylosyltransferase

Genes

HSA:	152002(XXYLT1)

PTR:	460947(XXYLT1)

PPS:	100970153(XXYLT1)

GGO:	101142478(XXYLT1)

PON:	100460349(XXYLT1)

NLE:	100579225(XXYLT1)

HMH:	116479986(XXYLT1)

MCC:	708627(XXYLT1)

MCF:	102136008(XXYLT1)

MTHB:

126947970

MNI:	105470806(XXYLT1)

CSAB:

103241959(XXYLT1)

CATY:

105575156(XXYLT1)

PANU:

101013294(XXYLT1)

TGE:	112619532(XXYLT1)

MLEU:

105545911(XXYLT1)

RRO:	104657013(XXYLT1)

RBB:	108530512(XXYLT1)

TFN:	117084423(XXYLT1)

PTEH:

111544311(XXYLT1)

CANG:

105525524(XXYLT1)

CJC:	100399864(XXYLT1)

SBQ:	101049767(XXYLT1)

CIMI:

108293283(XXYLT1)

CSYR:

103264284(XXYLT1)

MMUR:

105879789(XXYLT1)

LCAT:

123630412(XXYLT1)

PCOQ:

105806983(XXYLT1)

OGA:	100945058(XXYLT1)

MMU:	268880(Xxylt1)

MCAL:

110311553(Xxylt1)

MPAH:

110329798(Xxylt1)

RNO:	363799(Xxylt1)

MCOC:

116085792(Xxylt1)

ANU:	117718117(Xxylt1)

MUN:	110557090(Xxylt1)

CGE:	100760146(Xxylt1)

MAUA:

101823811(Xxylt1)

PROB:

127227057(Xxylt1)

PLEU:

114710019(Xxylt1)

MORG:

121461950(Xxylt1)

MFOT:

126512213

AAMP:

119825301(Xxylt1)

NGI:

103726562

HGL:	101724924(Xxylt1)

CPOC:

100735128(Xxylt1)

CCAN:

109692776 109692777(Xxylt1)

DORD:

105987929(Xxylt1)

DSP:	122099632(Xxylt1)

PLOP:

125351849(Xxylt1)

NCAR:

124990173 124992852

MMMA:

107143099(Xxylt1)

OCU:

100338252

OPI:	101518350(XXYLT1)

TUP:	102500896(XXYLT1)

GVR:	103586811(XXYLT1) 103601767

CFA:	609818(XXYLT1)

CLUD:

112676183(XXYLT1)

VVP:	112913548(XXYLT1)

VLG:	121499549(XXYLT1)

NPO:	129503764(XXYLT1)

AML:	100470521(XXYLT1)

UMR:	103678915(XXYLT1)

UAH:	113253333(XXYLT1)

UAR:	123802083(XXYLT1)

ELK:

111155075

LLV:

125102375

MPUF:

101693162(XXYLT1)

MNP:	132011920(XXYLT1)

MLK:	131824701(XXYLT1)

NVS:	122908818(XXYLT1)

ORO:	101362175(XXYLT1)

EJU:	114206925(XXYLT1)

ZCA:	113918662(XXYLT1)

MLX:	118006958(XXYLT1)

NSU:	110582493(XXYLT1)

LWW:	115941717(XXYLT1)

FCA:	101089207(XXYLT1)

PYU:	121036418(XXYLT1)

PCOO:

112849899(XXYLT1)

PBG:	122491590(XXYLT1)

PVIV:

125175387(XXYLT1)

LRUF:

124526639

PTG:	102954768(XXYLT1)

PPAD:

109266573(XXYLT1)

PUC:

125921060

AJU:

106976341

HHV:	120230653(XXYLT1)

BTA:	533703(XXYLT1)

BOM:	102265999(XXYLT1) 102282131

BIU:	109556401(XXYLT1)

BBUB:

102397599(XXYLT1)

BBIS:

104984576(XXYLT1)

CHX:	102181630(XXYLT1)

OAS:	105609977(XXYLT1)

BTAX:

128050042(XXYLT1)

ODA:	120869890(XXYLT1)

CCAD:

122444696(XXYLT1)

MBEZ:

129544215(XXYLT1)

SSC:	110256394(XXYLT1)

CFR:	102511937(XXYLT1)

CBAI:

105072427(XXYLT1)

CDK:	105101269(XXYLT1)

VPC:	102528842(XXYLT1)

BACU:

102999507(XXYLT1)

BMUS:

118894862(XXYLT1)

LVE:	103078312(XXYLT1)

OOR:	101269331(XXYLT1)

DLE:	111172441(XXYLT1)

PCAD:

102990205(XXYLT1)

PSIU:

116753542(XXYLT1)

NASI:

112404307(XXYLT1)

ECB:	100069238(XXYLT1)

EPZ:	103552433(XXYLT1)

EAI:	106843195(XXYLT1)

MYB:	102244349(XXYLT1)

MYD:	102759616(XXYLT1)

MMYO:

118676028(XXYLT1)

MLF:	102440865(XXYLT1)

PKL:	118723561(XXYLT1)

EFUS:

103295212(XXYLT1)

MNA:	107527359(XXYLT1)

DRO:	112301008(XXYLT1)

SHON:

118982990(XXYLT1)

AJM:	119055245(XXYLT1)

PDIC:

114490825(XXYLT1)

PHAS:

123827253(XXYLT1)

MMF:	118617640(XXYLT1)

PPAM:

129079895(XXYLT1)

HAI:	109386885(XXYLT1)

RFQ:	117012754(XXYLT1)

PALE:

102896075(XXYLT1)

PGIG:

120592840(XXYLT1)

PVP:	105307702 111733621

RAY:	107505287(XXYLT1)

MJV:	108399253(XXYLT1)

TOD:	119257409(XXYLT1)

SARA:

101536909(XXYLT1)

LAV:	104846154(XXYLT1)

TMU:

101340699

ETF:	101658713(XXYLT1)

DNM:	101416896(XXYLT1)

MDO:	103101409(XXYLT1)

GAS:	123242002(XXYLT1)

SHR:	100925178(XXYLT1)

AFZ:

127554182

PCW:	110193092(XXYLT1)

OAA:	100080620(XXYLT1)

GGA:	424896(XXYLT1)

PCOC:

116230860(XXYLT1)

MGP:	100546151(XXYLT1)

CJO:	107318249(XXYLT1)

TPAI:

128081695(XXYLT1)

LMUT:

125697837(XXYLT1)

NMEL:

110398006(XXYLT1)

APLA:

101796087(XXYLT1)

ACYG:

106039246(XXYLT1)

CATA:

118247090(XXYLT1)

AFUL:

116492402(XXYLT1)

TGU:	100221149(XXYLT1)

LSR:	110473868(XXYLT1)

SCAN:

103815639(XXYLT1)

PMOA:

120508601(XXYLT1)

OTC:	121341089(XXYLT1)

PRUF:

121357943(XXYLT1)

GFR:	102032493(XXYLT1)

FAB:	101813758(XXYLT1)

OMA:	130256966(XXYLT1)

PHI:	102103383(XXYLT1)

PMAJ:

107208582(XXYLT1)

CCAE:

111933472(XXYLT1)

CCW:	104693481(XXYLT1)

CBRC:

103624850(XXYLT1)

ETL:	114057622(XXYLT1)

ZAB:	102061732(XXYLT1)

ACHL:

103807224(XXYLT1)

SVG:	106860808(XXYLT1)

MMEA:

130583316(XXYLT1)

HRT:	120757211(XXYLT1)

FPG:	101911641(XXYLT1)

FCH:	102047871(XXYLT1)

CLV:	102093152(XXYLT1)

EGZ:	104127086(XXYLT1)

NNI:	104015739(XXYLT1)

PLET:

104626926(XXYLT1)

ACUN:

113483453(XXYLT1)

TALA:

104366424(XXYLT1)

PADL:

103913852(XXYLT1)

AFOR:

103901513(XXYLT1)

ACHC:

115346738(XXYLT1)

HLE:	104832311(XXYLT1)

AGEN:

126039625

GCL:

127020340

CCRI:

104161474(XXYLT1)

CSTI:

104556653(XXYLT1)

CMAC:

104480592(XXYLT1)

MUI:	104547685(XXYLT1)

BREG:

104641594(XXYLT1)

LDI:	104354586(XXYLT1)

OHA:	104338767(XXYLT1)

SHAB:

115611820(XXYLT1)

DPUB:

104307670(XXYLT1)

CPEA:

104392343(XXYLT1)

CVF:	104285039(XXYLT1)

RTD:	128911520(XXYLT1)

CUCA:

104063453(XXYLT1)

TEO:	104380282(XXYLT1)

AAM:	106485860(XXYLT1)

AROW:

112962147(XXYLT1)

NPD:	112947459(XXYLT1)

DNE:	112981707(XXYLT1)

SCAM:

104153238(XXYLT1)

ASN:	102370903(XXYLT1)

AMJ:	102576451(XXYLT1) 109286051

CPOO:

109308306(XXYLT1)

GGN:	109287781(XXYLT1)

PSS:	102452329(XXYLT1)

CMY:	102941143(XXYLT1)

CCAY:

125642757(XXYLT1)

CPIC:

101933120(XXYLT1)

TST:	117882760(XXYLT1)

CABI:

116823526(XXYLT1)

MRV:	120371831(XXYLT1)

ACS:	100556346(xxylt1)

ASAO:

132769761(XXYLT1)

PVT:	110087099(XXYLT1)

SUND:

121926921(XXYLT1)

PBI:	103068189(XXYLT1)

PMUR:

107291698(XXYLT1)

CTIG:

120307164(XXYLT1)

TSR:	106551580(XXYLT1)

PGUT:

117669841(XXYLT1)

APRI:

131200553(XXYLT1)

PTEX:

113450923(XXYLT1)

NSS:	113425178(XXYLT1)

VKO:	123018782(XXYLT1)

PMUA:

114598177(XXYLT1)

PRAF:

128414928(XXYLT1)

ZVI:	118093982(XXYLT1)

HCG:	128348725(XXYLT1)

GJA:	107125633(XXYLT1)

STOW:

125427075(XXYLT1)

EMC:	129332039(XXYLT1)

XLA:	446386(xxylt1.S)

XTR:	100495920(xxylt1)

NPR:	108795948(XXYLT1)

RTEM:

120936815(XXYLT1)

BBUF:

120997951(XXYLT1)

BGAR:

122933959(XXYLT1)

MUO:	115459088 115478301

GSH:	117367187(XXYLT1)

DRE:	449721(xxylt1)

SRX:	107715806 107718247

SANH:

107677510 107685961

SGH:	107551790(xxylt1) 107581703

CCAR:

109076241 109098340

CAUA:

113055328 113110938

CGIB:

127968555 128022176

PTET:

122353566(xxylt1)

LROH:

127172745(xxylt1)

OMC:	131549573(xxylt1)

PPRM:

120480807(xxylt1)

RKG:

130083556

MAMB:

125256592(xxylt1)

CIDE:

127522247

MASI:

127425914 127427752

TROS:

130571599(xxylt1)

TDW:	130409900(xxylt1)

MANU:

129427533(xxylt1)

IPU:

108271417

IFU:	128613613(xxylt1)

PHYP:

113536584(xxylt1)

SMEO:

124391479(xxylt1)

TFD:	113658942(xxylt1)

TVC:	132850145(xxylt1)

AMEX:

103024552(xxylt1)

CMAO:

118819113(xxylt1)

EEE:	113568717(xxylt1)

CHAR:

122131663

TRU:	101068186(xxylt1)

TFS:	130528859(xxylt1)

TNG:	GSTEN00019852G001 GSTEN00019874G001 GSTEN00024527G001

LCO:	104917761(xxylt1)

NCC:

104941403

TBEN:

117496008(xxylt1)

CGOB:

115007476(xxylt1)

PGEO:

117445973(xxylt1)

GACU:

117555225(xxylt1)

EMAC:

134870200(xxylt1)

ELY:	117254288(xxylt1)

EFO:	125895786(xxylt1)

PLEP:

121941278(xxylt1)

SLUC:

116055357(xxylt1)

ECRA:

117951046(xxylt1)

ESP:	116696224(xxylt1)

PFLV:

114561949(xxylt1)

GAT:	120824028(xxylt1)

PPUG:

119216399(xxylt1)

AFB:	129094804(xxylt1)

CLUM:

117729229(xxylt1)

PSWI:

130193657(xxylt1)

MSAM:

119881901 119900612(xxylt1) 119903385 119915313

SCHU:

122878379(xxylt1)

CUD:	121512472(xxylt1)

ALAT:

119028942(xxylt1)

MZE:	101466919(xxylt1)

ONL:	100690495(xxylt1)

OAU:	116334671(xxylt1)

OLA:	101163562(xxylt1)

OML:	112150897(xxylt1)

CSAI:

133457819(xxylt1)

XMA:	102231578(xxylt1)

XCO:	114151515(xxylt1)

XHE:	116726421(xxylt1)

PRET:

103463487(xxylt1)

PFOR:

103130648(xxylt1)

PLAI:

106948180(xxylt1)

PMEI:

106930556(xxylt1)

GAF:	122838711(xxylt1)

PPRL:

129369419(xxylt1)

CVG:	107101869(xxylt1)

CTUL:

119794237(xxylt1)

GMU:	124873399(xxylt1)

NFU:	107392723(xxylt1)

KMR:	108234396(xxylt1)

ALIM:

106511148(xxylt1)

NWH:	119430766(xxylt1)

AOCE:

111569259(xxylt1) 111585648

MCEP:

125009998(xxylt1)

CSEM:

103392422(xxylt1)

POV:	109625868(xxylt1)

SSEN:

122780724(xxylt1)

HHIP:

117759775(xxylt1)

HSP:	118120762(xxylt1)

SMAU:

118317661(xxylt1)

LCF:

108881258

SDU:	111217564(xxylt1)

SLAL:

111649488(xxylt1)

XGL:	120791269(xxylt1)

HCQ:	109522088(xxylt1)

SSCV:

125976077

SBIA:

133504054(xxylt1)

PEE:	133406174(xxylt1)

PTAO:

133480993(xxylt1)

BPEC:

110160195(xxylt1)

MALB:

109958238(xxylt1)

BSPL:

114854640(xxylt1)

SJO:	128361761(xxylt1)

SASA:

106573863 106613663(xxylt1)

STRU:

115151719

OTW:	112252170(xxylt1)

OMY:	110498260(xxylt1)

OGO:

123998583

ONE:

115109182

OKI:

109889157

OKE:

118401428

SALP:

111952861

SNH:

120053746

CCLU:

121533634(xxylt1) 121576837

ELS:	105011423(xxylt1)

SFM:	108937178(xxylt1)

PKI:	111848178(xxylt1)

AANG:

118224719(xxylt1)

LOC:	102697515(xxylt1)

PSPA:

121307632 121323443 121327319(xxylt1)

ARUT:

117416976(xxylt1) 117423164

PSEX:

120537329(xxylt1)

LCM:	102357578(XXYLT1)

CMK:	103184429(xxylt1)

HOC:	132821869(xxylt1)

LERI:

129703612(xxylt1)

PMRN:

116943804(XXYLT1)

LRJ:	133355523(XXYLT1)

BFO:

118408601

BBEL:

109486527

CIN:

100176443

SCLV:

120326789

SPU:	115918677 115918680 575308 575517

LPIC:

129276233 129276595

APLC:

110976527

SKO:

100375634

DME:	Dmel_CG11388(Xxylt)

DER:

6548393

DSE:

6615836

DSI:	Dsimw501_GD29218(Dsim_GD29218)

DYA:	Dyak_GE14358

DAN:

6495736

DSR:

110191656

DPO:

4804298

DPE:

6590999

DMN:

108160957

DWI:

6640167

DGR:

6560070

DMO:	Dmoj_GI20695

DAZ:

108616316

DNV:

115564424

DHE:

111600132

MDE:

101896527

SCAC:

106085421

LCQ:

111678025

LSQ:

119607460

GFS:	119636213 119641593

ECOE:

129952564

CLON:

129615736

HIS:

119648628

AGA:

1269625

ACOZ:

120952943

AARA:

120893808

AMER:

121591396

ASTE:

118512092

AFUN:

125768691

AMOU:

128300809

AALI:

118466661

AAG:

5571606

AALB:

109408514

CQU:	CpipJ_CPIJ000257

CPII:

120427115

BCOO:

119080146

AME:

724932

ACER:

108002892

ALAB:

122711485

ADR:

102670731

AFLR:

100865855

BIM:

100749882

BBIF:

117214485

BVK:

117242626

BVAN:

117161231

BTER:

100643598

BAFF:

126925850

BPYO:

122576432

BPAS:

132914728

FVI:

122527156

CCAL:

108626498

OBB:

114877841

OLG:

117608971

MGEN:

117224053

NMEA:

116430770

CGIG:

122402252

SOC:

113003780

MPHA:

105839668

AEC:

105152620

ACEP:

105620818

PBAR:

105429965

VEM:

105569072

HST:

105186701

DQU:

106749119

CFO:

105254221

FEX:

115236631

LHU:

105669086

PGC:

109859868

OBO:

105275640

PCF:

106789677

PFUC:

122518881

VPS:

122634460

VCRB:

124430072

VVE:

124954699

NVI:

100123940

CSOL:

105363607

TPRE:

106655456

LHT:

122500956

LBD:

127288525

MDL:

103580061

FAS:

105268964

DAM:

107035736

AGIF:

122859188

CINS:

118064990

VCAN:

122418328 122418762

CCIN:

107266371

DSM:

124408995

NPT:

124217812

NFB:

124181201

NLO:

107216736

NVG:

124303686

AROA:

105684190

TCA:

660293

DPA:

109539050

SOY:

115886385

AGRG:

126743709

ATD:

109599045

CSET:

123312434

AGB:

108917065

LDC:

111510685

NVL:

108558286

APLN:

108735005

PPYR:

116171245

OTU:

111425250

CFEL:

113366679

CCRN:

123305029

API:

100166315

DNX:

107161488

AGS:	114128320 114128325

RMD:

113548568

ACOO:

126839288

DVT:

126894596

BTAB:

109038038

DCI:

103505046

CLEC:

106663143

HHAL:

106689874

NLU:

111059486

HVI:

124360053

MQU:

128991900

PHU:	Phum_PHUM498320

FOC:

113205198

TPAL:

117644944

ZNE:

110827477

CSEC:

111862437

SGRE:

126269433

IEL:	124166648 124167925

DPX:	DAPPUDRAFT_210281

DMK:	116929617 116933696 123474008

DPZ:

124311232

PVM:

113805334

PJA:

122250183

PCHN:

125026344

PMOO:

119580451

HAME:

121862950

PCLA:

123758731

PTRU:

123514520

ESN:

126995417

HAZT:

108666219

EAF:	111697990 111699263 111699268 111699566 111708450 111709088 111709097 111711480 111712451 111714345 111715508 111715934

LSM:

121116899

TCF:

131885967

PPOI:

119096272 119096274

DSV:	119444486 119444958 119445983 119450235

RSAN:

119383281 119383282 119390457

RMP:	119170447 119171742

DPTE:

113798364

DFR:

124495123

CSCU:

111613684 111620252 111620253

PTEP:

107452048 107453466

ABRU:

129964262 129983754

UDV:	129222219 129226311

SDM:	118183721 118203439

LPOL:

106457140 106461570

HRO:	HELRODRAFT_157060

LGI:	LOTGIDRAFT_113431

PVUL:

126828229

PCAN:

112558122

BGT:

106078720

GAE:	121390449 121390592

HRF:

124117744

HRJ:

124257495

CRG:

105318731

CVN:

111134662

CANU:

128188890

OED:

125660830

MYI:

110458899

PMAX:

117314575

MCAF:

127719857

MMER:

123527279

RPHI:

132748362

DPOL:

127841067 127841694 127842085

OBI:

106876761

OSN:

115224413

LAK:

106176825

NVE:

5509033

EPA:

110254287

ATEN:

116304657

ADF:

107337704

AMIL:

114973463

PDAM:

113674169

SPIS:

111332430

DGT:

114518404

XEN:

124444210

HMG:

100205303

HSY:

130642106

TAD:	TRIADDRAFT_50070

» show all

Reference

1 [PMID:8982869]

Authors

Minamida S, Aoki K, Natsuka S, Omichi K, Fukase K, Kusumoto S, Hase S

Title

Detection of UDP-D-xylose: alpha-D-xyloside alpha 1-->3xylosyltransferase activity in human hepatoma cell line HepG2.

Journal

J Biochem 120:1002-6 (1996)
DOI:10.1093/oxfordjournals.jbchem.a021492

Reference

2 [PMID:22117070]

Authors

Sethi MK, Buettner FF, Ashikov A, Krylov VB, Takeuchi H, Nifantiev NE, Haltiwanger RS, Gerardy-Schahn R, Bakker H

Title

Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch.

Journal

J Biol Chem 287:2739-48 (2012)
DOI:10.1074/jbc.M111.302406

Sequence

[hsa:152002]

Reference

3 [PMID:26414444]

Authors

Yu H, Takeuchi M, LeBarron J, Kantharia J, London E, Bakker H, Haltiwanger RS, Li H, Takeuchi H

Title

Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism.

Journal

Nat Chem Biol 11:847-54 (2015)
DOI:10.1038/nchembio.1927

Sequence

[mmu:268880]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.2.62

IUBMB Enzyme Nomenclature:

2.4.2.62

ExPASy - ENZYME nomenclature database:

2.4.2.62

BRENDA, the Enzyme Database:

2.4.2.62

DBGET integrated database retrieval system