Entry
Name
EGF-domain serine xylosyltransferase;
POGLUT1 (gene name) (ambiguous);
rumi (gene name) (ambiguous)
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-xylose:[protein with EGF-like domain]-L-serine O-beta-xylosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine = UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine [RN:
R05925 ]
Reaction(KEGG)
Substrate
UDP-alpha-D-xylose [CPD:
C00190 ];
[protein with EGF-like domain]-L-serine
Product
UDP [CPD:
C00015 ];
[protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine
Comment
The enzyme, found in animals and insects, xylosylates at the serine in the C-X-S-X-P-C motif of epidermal growth factor-like (EGF-like) domains. The enzyme is bifunctional also being active with UDP-alpha-glucose as donor (EC
2.4.1.376 , EGF-domain serine glucosyltransferase).
History
EC 2.4.2.63 created 2020
Orthology
K13667 EGF-domain serine glucosyl/xylosyltransferase
Genes
PPAM : 129069649(POGLUT1) 129082265
XLA : 108707382(poglut1.L) 446695(poglut1.S)
SRX : 107739820 107742654(poglut1)
SGH : 107552365 107552368 107588837(poglut1)
CCAR : 109083311 109093877
PPRL : 129353787 129379065
OKE : 118363831(poglut1) 118370267
SALP : 111953666(poglut1) 111971149
PSPA : 121320912 121327858
ARUT : 117406369 117406601
LRJ : 133355521(POGLUT1) 133355555
LPIC : 129256537 129256538
DME : Dmel_CG31139(CG31139) Dmel_CG31152(rumi)
DSI : Dsimw501_GD18424(Dsim_GD18424) Dsimw501_GD18425(Dsim_GD18425)
RZE : 108365540 108365541 108370983
CFEL : 113370866 113370868 113371601
PMOO : 119585388 119585392
PPOI : 119095389 119111021
CRE : CHLRE_07g344500v5 CHLRE_08g367750v5
SMIN : v1.2.002892.t1(symbB.v1.2.002892.t1) v1.2.004773.t1(symbB.v1.2.004773.t1)
EHX : EMIHUDRAFT_227650 EMIHUDRAFT_242134 EMIHUDRAFT_249850 EMIHUDRAFT_252748 EMIHUDRAFT_441372 EMIHUDRAFT_79465
» show all
Taxonomy
Reference
Authors
Li Z, Fischer M, Satkunarajah M, Zhou D, Withers SG, Rini JM
Title
Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein-O-glucosyltransferase 1 (POGLUT1).
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.63
ExPASy - ENZYME nomenclature database: 2.4.2.63