KEGG ENZYME: 2.4.3.8

ENZYME: 2.4.3.8

Entry

EC 2.4.3.8                  Enzyme

Name

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase;
cytidine monophosphoacetylneuraminate-ganglioside GM3;
alpha-2,8-sialyltransferase;
ganglioside GD3 synthase;
ganglioside GD3 synthetase sialyltransferase;
CMP-NeuAc:LM1(alpha2-8) sialyltranferase;
GD3 synthase;
SAT-2

Class

Transferases;
Glycosyltransferases;
Sialyltransferases

Sysname

CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-(2->3)-beta-D-galactoside alpha-(2->8)-N-acetylneuraminyltransferase

Reaction(IUBMB)

CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R [RN:R04564]

Reaction(KEGG)

R04564 > R04583 R05940(G) R05947(G) R06032(G) R13175(G);
(other) R04632 R04649 R04661 R05113 R05995(G) R06000(G) R06005(G) R06009(G)

Substrate

CMP-N-acetylneuraminate [CPD:C00128];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R

Product

CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R

Comment

Gangliosides act as acceptors.

History

EC 2.4.3.8 created 1984 as EC 2.4.99.8, modified 1986, transferred 2022 to EC 2.4.3.8

Pathway

ec00601

Glycosphingolipid biosynthesis - lacto and neolacto series

ec00603

Glycosphingolipid biosynthesis - globo and isoglobo series

ec00604

Glycosphingolipid biosynthesis - ganglio series

ec01100

Metabolic pathways

Orthology

K03371

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)

Genes

HSA:	6489(ST8SIA1)

PTR:	465341(ST8SIA1)

PPS:	100970748(ST8SIA1)

GGO:	101134419(ST8SIA1)

PON:	100455082(ST8SIA1)

NLE:	100588840(ST8SIA1)

HMH:	116472771(ST8SIA1)

MCC:	706707(ST8SIA1)

MCF:	102118571(ST8SIA1)

MTHB:

126930525

MNI:	105492107(ST8SIA1)

CSAB:

103218743(ST8SIA1)

CATY:

105585055(ST8SIA1)

PANU:

101010038(ST8SIA1)

TGE:	112635598(ST8SIA1)

MLEU:

105535615

RRO:	104660754(ST8SIA1)

RBB:	108541110(ST8SIA1)

TFN:	117090396(ST8SIA1)

PTEH:

111540637(ST8SIA1)

CANG:

105521116(ST8SIA1)

CJC:	118144189(ST8SIA1)

SBQ:	101042881(ST8SIA1)

CIMI:

108300261(ST8SIA1)

MMUR:

105882799(ST8SIA1)

LCAT:

123639934(ST8SIA1)

PCOQ:

105807576(ST8SIA1)

OGA:	100950426(ST8SIA1)

MMU:	20449(St8sia1)

MCAL:

110296666(St8sia1)

MPAH:

110316454(St8sia1)

RNO:	25280(St8sia1)

MCOC:

116099770(St8sia1)

ANU:	117714671(St8sia1)

MUN:	110560539(St8sia1)

CGE:	100768920(St8sia1)

MAUA:

101833067(St8sia1)

PROB:

127213126(St8sia1)

PLEU:

114700282(St8sia1)

MORG:

121437731(St8sia1)

MFOT:

126497325

AAMP:

119808271(St8sia1)

NGI:	103736726(St8sia1)

HGL:	101696963(St8sia1)

CPOC:

100715414(St8sia1)

CCAN:

109700114(St8sia1)

DORD:

105992241(St8sia1)

DSP:

122102811

PLOP:

125342728(St8sia1)

NCAR:

124983767

MMMA:

107152803(St8sia1)

OCU:

100351155

OPI:	101532071(ST8SIA1)

TUP:	102468919(ST8SIA1)

GVR:	103599358(ST8SIA1)

CFA:	477672(ST8SIA1)

CLUD:

112665513(ST8SIA1)

VVP:	112917220(ST8SIA1)

VLG:	121480215(ST8SIA1)

NPO:	129505598(ST8SIA1)

AML:	100464397(ST8SIA1)

UMR:	103665233(ST8SIA1)

UAH:	113257801(ST8SIA1)

UAR:	123801659(ST8SIA1)

ELK:

111159987

LLV:

125107481

MPUF:

101693103(ST8SIA1)

MNP:	132019570(ST8SIA1)

MLK:	131838912(ST8SIA1)

NVS:	122891780(ST8SIA1)

ORO:	101366887(ST8SIA1)

EJU:	114216633(ST8SIA1)

ZCA:	113922906(ST8SIA1)

MLX:	118025582(ST8SIA1)

NSU:	110581009(ST8SIA1)

LWW:	102733721(ST8SIA1)

FCA:	101093029(ST8SIA1)

PYU:	121038820(ST8SIA1)

PCOO:

112867675(ST8SIA1)

PBG:	122473547(ST8SIA1)

PVIV:

125171212(ST8SIA1)

LRUF:

124502469

PTG:	102962819(ST8SIA1)

PPAD:

109268731(ST8SIA1)

PUC:

125918896

AJU:

106967976

HHV:	120236008(ST8SIA1)

BTA:	282352(ST8SIA1)

BOM:	102273511(ST8SIA1)

BIU:	109559591(ST8SIA1)

BBUB:

102401968(ST8SIA1)

BBIS:

105000216(ST8SIA1)

CHX:	102187381(ST8SIA1)

OAS:	101117321(ST8SIA1)

BTAX:

128048547(ST8SIA1)

ODA:	120858934(ST8SIA1)

CCAD:

122423333(ST8SIA1)

MBEZ:

129535648(ST8SIA1)

SSC:	100625270(ST8SIA1)

CFR:	102512853(ST8SIA1)

CBAI:

105062287(ST8SIA1)

CDK:	105096526(ST8SIA1)

VPC:	102526499(ST8SIA1)

BACU:

103009301(ST8SIA1)

BMUS:

118902638(ST8SIA1)

LVE:	103076775(ST8SIA1)

OOR:	101285691(ST8SIA1)

DLE:	111176840(ST8SIA1)

PCAD:

102987127(ST8SIA1)

PSIU:

116760632(ST8SIA1)

NASI:

112391788(ST8SIA1)

ECB:	100064415(ST8SIA1) 111772030 111772221 111772374

EPZ:	103554941(ST8SIA1)

EAI:	106825576(ST8SIA1)

MYB:	102249041(ST8SIA1)

MYD:

102769678

MMYO:

118650342(ST8SIA1)

MLF:	102436879(ST8SIA1)

PKL:	118730430(ST8SIA1)

EFUS:

103285148(ST8SIA1)

MNA:	107525320(ST8SIA1)

DRO:	112318440(ST8SIA1)

SHON:

118978440(ST8SIA1)

AJM:	119048980(ST8SIA1)

PDIC:

114513284(ST8SIA1)

PHAS:

123812877(ST8SIA1)

MMF:	118624046(ST8SIA1)

PPAM:

129084976(ST8SIA1)

HAI:	109375156(ST8SIA1)

RFQ:	117028889(ST8SIA1)

PALE:

102892181(ST8SIA1)

PGIG:

120618362(ST8SIA1)

PVP:	105306530(ST8SIA1)

RAY:	107508581(ST8SIA1)

MJV:	108398355(ST8SIA1)

TOD:	119247638(ST8SIA1)

SARA:

101536942(ST8SIA1)

SETR:

126022805(ST8SIA1)

LAV:	100659787(ST8SIA1)

TMU:

101359255

ETF:	101651002(ST8SIA1)

DNM:	101439062(ST8SIA1)

MDO:	100011205(ST8SIA1)

GAS:	123250017(ST8SIA1)

SHR:	100920916(ST8SIA1)

AFZ:

127539289

PCW:	110213804(ST8SIA1)

OAA:	100080234(ST8SIA1)

GGA:	395860(ST8SIA1)

PCOC:

116231405(ST8SIA1)

MGP:	100547921(ST8SIA1)

CJO:	107317147(ST8SIA1)

TPAI:

128084524(ST8SIA1)

LMUT:

125697894(ST8SIA1)

NMEL:

110396210(ST8SIA1)

APLA:

101797310(ST8SIA1)

ACYG:

106038258(ST8SIA1)

CATA:

118245122(ST8SIA1)

AFUL:

116502321(ST8SIA1)

TGU:	100225976(ST8SIA1)

LSR:	110470391(ST8SIA1)

SCAN:

103820535(ST8SIA1)

PMOA:

120497130(ST8SIA1)

OTC:	121332784(ST8SIA1)

PRUF:

121362718(ST8SIA1)

GFR:	102037290(ST8SIA1)

FAB:	101806998(ST8SIA1)

OMA:	130267021(ST8SIA1)

PHI:	102111773(ST8SIA1)

PMAJ:

107204564(ST8SIA1)

CCAE:

111923319(ST8SIA1)

CCW:	104692305(ST8SIA1)

CBRC:

103617289(ST8SIA1)

ETL:	114069418(ST8SIA1)

ZAB:	102064143(ST8SIA1)

ACHL:

103800160(ST8SIA1)

SVG:	106855510(ST8SIA1)

MMEA:

130575566(ST8SIA1)

HRT:	120751890(ST8SIA1)

FPG:	101922614(ST8SIA1)

FCH:	102056471(ST8SIA1)

CLV:	102093502(ST8SIA1)

EGZ:	104135090(ST8SIA1)

NNI:	104012705(ST8SIA1)

PCRI:

104034257

PCAO:

104043589(ST8SIA1)

ACUN:

113487646(ST8SIA1)

TALA:

104365612(ST8SIA1)

PADL:

103924330(ST8SIA1)

AFOR:

103898734(ST8SIA1)

ACHC:

115352512(ST8SIA1)

AGEN:

126047785

GCL:

127019811

CCRI:

104168338(ST8SIA1)

CSTI:

104564133(ST8SIA1)

CMAC:

104479213

LDI:	104347216(ST8SIA1)

OHA:	104327191(ST8SIA1)

NNT:	104403606(ST8SIA1)

SHAB:

115605291(ST8SIA1)

DPUB:

104299482(ST8SIA1)

PGUU:

104466166

ACAR:

104521623(ST8SIA1)

CPEA:

104393457(ST8SIA1)

CVF:	104281725(ST8SIA1)

RTD:	128910513(ST8SIA1)

CUCA:

104059493(ST8SIA1)

TEO:	104372828(ST8SIA1)

BRHI:

104489776

AAM:	106488295(ST8SIA1)

AROW:

112966614(ST8SIA1)

NPD:	112944369(ST8SIA1)

TGT:	104578998(ST8SIA1)

DNE:	112978905(ST8SIA1)

SCAM:

104154118(ST8SIA1)

ASN:	102378302(ST8SIA1)

AMJ:	102562267(ST8SIA1)

CPOO:

109316395(ST8SIA1)

GGN:	109296296(ST8SIA1)

PSS:	102462829(ST8SIA1)

CMY:	102943965(ST8SIA1)

CCAY:

125625048(ST8SIA1)

DCC:	119850214(ST8SIA1)

CPIC:

101937464(ST8SIA1)

TST:	117883367(ST8SIA1)

CABI:

116835477(ST8SIA1)

MRV:	120371084(ST8SIA1)

ACS:	100337536(st8sia1)

ASAO:

132775711(ST8SIA1)

PVT:	110091198(ST8SIA1)

SUND:

121930321(ST8SIA1)

PBI:	103065178(ST8SIA1)

PMUR:

107295788(ST8SIA1)

CTIG:

120309794(ST8SIA1)

TSR:	106547779(ST8SIA1)

PGUT:

117679860(ST8SIA1)

APRI:

131202524(ST8SIA1)

PTEX:

113437871(ST8SIA1)

NSS:	113419064(ST8SIA1)

VKO:	123034657(ST8SIA1)

PMUA:

114605143(ST8SIA1)

PRAF:

128422080(ST8SIA1)

ZVI:	118091196(ST8SIA1)

HCG:	128327158(ST8SIA1)

GJA:

107105667

STOW:

125434326(ST8SIA1)

EMC:	129336057(ST8SIA1)

XLA:	108712513(st8sia1.S) 398735(st8sia1.L)

XTR:	444887(st8sia1)

NPR:	108789879(ST8SIA1)

RTEM:

120932763(ST8SIA1)

BBUF:

121005110(ST8SIA1)

BGAR:

122926561(ST8SIA1)

DRE:	553210(st8sia1)

SRX:	107748471 107755164

SANH:

107689712(st8sia1)

SGH:

107567669

CCAR:

109045336 109066147

CAUA:

113048254 113061141

CGIB:

127956856 127972491

PTET:

122342725(st8sia1)

LROH:

127164321(st8sia1)

OMC:	131539055(st8sia1)

PPRM:

120477091(st8sia1)

RKG:	130092533(st8sia1)

MAMB:

125245379(st8sia1)

CIDE:

127511328

MASI:

127435346 127436847

TROS:

130547566(st8sia1)

TDW:	130420284(st8sia1)

MANU:

129432559(st8sia1)

IPU:	108279455(st8sia1) 108279490

IFU:	128623476(st8sia1) 128623558

PHYP:

113531749(st8sia1)

SMEO:

124401145(st8sia1)

TFD:	113647226(st8sia1)

TVC:	132859374(st8sia1)

AMEX:

103035159(st8sia1)

CMAO:

118812360(st8sia1)

EEE:	113584008(st8sia1)

CHAR:

105889648(st8sia1) 105892368 105892371 105892372 105909703 116219229

TRU:	445978(st8sia1)

TFS:	130519207(st8sia1)

TNG:	GSTEN00020858G001

LCO:	109141779(st8sia1)

NCC:	104958359(st8sia1)

TBEN:

117485063(st8sia1)

CGOB:

115028360(st8sia1)

PGEO:

117439298(st8sia1)

GACU:

117547931(st8sia1)

EMAC:

134879382(st8sia1)

ELY:	117249341(st8sia1)

EFO:	125882523(st8sia1)

PLEP:

121961498(st8sia1)

SLUC:

116060120(st8sia1)

ECRA:

117938764(st8sia1)

ESP:	116673185(st8sia1)

PFLV:

114550187(st8sia1)

GAT:

100174872

PPUG:

119211090(st8sia1)

AFB:	129112618(st8sia1)

CLUM:

117726120(st8sia1)

PSWI:

130200293(st8sia1)

MSAM:

119918439(st8sia1)

SCHU:

122871344(st8sia1)

CUD:	121505444(st8sia1)

ALAT:

119032673(st8sia1)

MZE:	101480363(st8sia1)

ONL:	100695121(st8sia1)

OAU:	116309833(st8sia1)

OLA:	100049518(st8sia1)

OML:	112155472(st8sia1)

CSAI:

133423960(st8sia1)

XMA:	102218717(st8sia1)

XCO:	114141471(st8sia1)

XHE:	116736502(st8sia1)

PRET:

103459243(st8sia1)

PFOR:

103146226(st8sia1)

PLAI:

106961373 106961377

PMEI:

106931844(st8sia1)

GAF:	122826653(st8sia1)

PPRL:

129375504(st8sia1)

CVG:	107085992(st8sia1)

CTUL:

119785664(st8sia1)

GMU:	124883158(st8sia1)

NFU:	107379800(st8sia1)

KMR:	108235108(st8sia1)

ALIM:

106533543(st8sia1)

NWH:	119428390(st8sia1)

AOCE:

111571510(st8sia1)

MCEP:

125000032(st8sia1)

CSEM:

103382754(st8sia1)

POV:	109632888(st8sia1)

SSEN:

122767240(st8sia1)

HHIP:

117756967(st8sia1)

HSP:	118101632(st8sia1)

SMAU:

118287693(st8sia1)

LCF:

108879661

SDU:	111224971(st8sia1)

SLAL:

111671912(st8sia1)

XGL:	120802191(st8sia1)

HCQ:	109523778(st8sia1)

SSCV:

125992241

SBIA:

133493589(st8sia1)

PEE:	133396986(st8sia1)

PTAO:

133471915(st8sia1)

BPEC:

110170325(st8sia1)

MALB:

109959852(st8sia1)

BSPL:

114862095(st8sia1)

SJO:	128353385(st8sia1)

SASA:

106595526 106609639(st8sia1)

STRU:

115180086 115199122

OTW:	112242451(st8sia1)

OMY:	110499835 118936578

OGO:	124026144(st8sia1)

ONE:

115114980

OKI:	109879214(st8sia1)

OKE:	118372698(st8sia1)

SNH:	120036006 120040271

CCLU:

121543396 121549897

ELS:	105020361(st8sia1)

SFM:	108936438 108942102

PKI:	111846118 111846528

AANG:

118219081(st8sia1) 118231201

LOC:	102694617(st8sia1)

PSPA:

121318379 121319722

ARUT:

117414707 117419486

PSEX:

120534204(st8sia1)

LCM:	102350065(ST8SIA1)

CMK:	103181078(st8sia1)

RTP:	109917984(st8sia1)

CPLA:

122561586(st8sia1)

HOC:	132826941(st8sia1)

LERI:

129707670

PMRN:

103091726(ST8SIA1)

LRJ:	133351486(ST8SIA1)

LPIC:

129272954 129272955

» show all

Reference

1 [PMID:7407217]

Authors

Eppler CM, Morre DJ, Keenan TW.

Title

Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides.

Journal

Biochim Biophys Acta 619:332-43 (1980)
DOI:10.1016/0005-2760(80)90081-8

Reference

2 [PMID:3838172]

Authors

Higashi H, Basu M, Basu S.

Title

Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain.

Journal

J Biol Chem 260:824-8 (1985)

Reference

3 [PMID:4044605]

Authors

McCoy RD, Vimr ER, Troy FA.

Title

CMP-NeuNAc:poly-alpha-2,8-sialosyl sialyltransferase and the biosynthesis of polysialosyl units in neural cell adhesion molecules.

Journal

J Biol Chem 260:12695-9 (1985)

Reference

4 [PMID:6766128]

Authors

Yohe HC, Yu RK.

Title

In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a.

Journal

J Biol Chem 255:608-13 (1980)

Other DBs

ExplorEnz - The Enzyme Database:

2.4.3.8

IUBMB Enzyme Nomenclature:

2.4.3.8

ExPASy - ENZYME nomenclature database:

2.4.3.8

BRENDA, the Enzyme Database:

2.4.3.8

CAS:	67339-00-8

DBGET integrated database retrieval system