KEGG ENZYME: 2.4.3.9

ENZYME: 2.4.3.9

Entry

EC 2.4.3.9                  Enzyme

Name

lactosylceramide alpha-2,3-sialyltransferase;
cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase;
CMP-acetylneuraminate-lactosylceramide-sialyltransferase;
CMP-acetylneuraminic acid:lactosylceramide sialyltransferase;
CMP-sialic acid:lactosylceramide-sialyltransferase;
cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase;
ganglioside GM3 synthetase;
GM3 synthase;
GM3 synthetase;
SAT 1;
CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase;
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide alpha-(2->3)-N-acetylneuraminyltransferase

Class

Transferases;
Glycosyltransferases;
Sialyltransferases

Sysname

CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide alpha-(2->3)-N-acetylneuraminyltransferase

Reaction(IUBMB)

CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03488 R05937]

Reaction(KEGG)

R03488 R05937(G);
(other) R04630 R04647 R06003(G) R06007(G)

Substrate

CMP-N-acetylneuraminate [CPD:C00128];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]

Product

CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Comment

Lactose cannot act as acceptor.

History

EC 2.4.3.9 created 1984 as EC 2.4.99.9, modified 1986, transferred 2022 to EC 2.4.3.9

Pathway

ec00604

Glycosphingolipid biosynthesis - ganglio series

ec01100

Metabolic pathways

Orthology

K03370

lactosylceramide alpha-2,3-sialyltransferase (sialyltransferase 9)

Genes

HSA:	8869(ST3GAL5)

PTR:	459371(ST3GAL5)

PPS:	100974771(ST3GAL5)

GGO:	101127197(ST3GAL5)

PON:	100458488(ST3GAL5)

NLE:	100581835(ST3GAL5)

HMH:	116483175(ST3GAL5)

MCC:	696842(ST3GAL5)

MCF:	102139258(ST3GAL5)

MTHB:

126933402

MNI:	105465394(ST3GAL5) 105481651

CSAB:

103219931(ST3GAL5)

CATY:

105587659(ST3GAL5)

PANU:

101025433(ST3GAL5)

TGE:	112604851(ST3GAL5)

MLEU:

105528861(ST3GAL5)

RRO:	104677060(ST3GAL5)

RBB:	108518136(ST3GAL5)

TFN:	117062146(ST3GAL5)

PTEH:

111551103(ST3GAL5)

CANG:

105527701(ST3GAL5)

CJC:	100399856(ST3GAL5)

SBQ:	101033571(ST3GAL5)

CIMI:

108309994(ST3GAL5)

CSYR:

103266514(ST3GAL5)

MMUR:

105876608(ST3GAL5)

LCAT:

123637135(ST3GAL5)

PCOQ:

105810293(ST3GAL5)

OGA:	100951715(ST3GAL5)

MMU:	20454(St3gal5)

MCAL:

110296137(St3gal5)

MPAH:

110316218(St3gal5)

RNO:	83505(St3gal5)

MCOC:

116099070(St3gal5)

ANU:	117715659(St3gal5)

MUN:	110558892(St3gal5)

CGE:	100754838(St3gal5)

MAUA:

101843771(St3gal5)

PROB:

127235575(St3gal5)

PLEU:

114685874(St3gal5)

MORG:

121440411(St3gal5)

MFOT:

126491042

AAMP:

119807969(St3gal5)

NGI:	103739804(St3gal5)

HGL:	101699085(St3gal5)

CPOC:

100728609(St3gal5)

CCAN:

109696130(St3gal5)

DORD:

106000225(St3gal5)

DSP:	122116892(St3gal5)

PLOP:

125356216(St3gal5)

NCAR:

124962985

MMMA:

107159736(St3gal5)

OCU:

100341761

OPI:	101524576(ST3GAL5)

TUP:	102502390(ST3GAL5)

GVR:	103603572(ST3GAL5)

CFA:	612022(ST3GAL5)

CLUD:

112664330(ST3GAL5)

VVP:	112916669(ST3GAL5)

VLG:	121491257(ST3GAL5)

NPO:	129510928(ST3GAL5)

AML:	100469790(ST3GAL5)

UMR:	103671460(ST3GAL5)

UAH:	113243005(ST3GAL5)

UAR:	123799693(ST3GAL5)

ELK:

111148102

LLV:

125108483

MPUF:

101679411(ST3GAL5)

MNP:	132021389(ST3GAL5)

MLK:	131840402(ST3GAL5)

NVS:	122915058(ST3GAL5)

ORO:	101377844(ST3GAL5)

EJU:	114223482(ST3GAL5)

ZCA:	113937947(ST3GAL5)

MLX:	118007900(ST3GAL5)

NSU:	110587152(ST3GAL5)

LWW:	102745883(ST3GAL5)

FCA:	101092099(ST3GAL5)

PYU:	121044504(ST3GAL5)

PCOO:

112864202(ST3GAL5)

PBG:	122497125(ST3GAL5)

PVIV:

125161794(ST3GAL5)

LRUF:

124503124

PTG:	102964432(ST3GAL5)

PPAD:

109264005(ST3GAL5)

PUC:

125937413

AJU:

106978128

HHV:	120245540(ST3GAL5)

BTA:	404164(ST3GAL5)

BOM:	102266477(ST3GAL5)

BIU:	109566161(ST3GAL5)

BBUB:

102397894(ST3GAL5)

BBIS:

105004571(ST3GAL5)

CHX:	102190883(ST3GAL5)

OAS:	101104977(ST3GAL5)

BTAX:

128056454(ST3GAL5)

ODA:	120851510(ST3GAL5)

CCAD:

122441752(ST3GAL5)

MBEZ:

129539126(ST3GAL5)

SSC:	100625751(ST3GAL5)

CFR:	102505366(ST3GAL5)

CBAI:

105072111(ST3GAL5)

CDK:	105104164(ST3GAL5)

VPC:	102545029(ST3GAL5)

BACU:

103002546(ST3GAL5)

BMUS:

118906137(ST3GAL5)

LVE:	103075319(ST3GAL5)

OOR:	101270788(ST3GAL5)

DLE:	111165451(ST3GAL5)

PCAD:

102983416(ST3GAL5)

PSIU:

116764105(ST3GAL5)

NASI:

112398883(ST3GAL5)

ECB:	100067118(ST3GAL5) 111771968 111771995

EPZ:	103556956(ST3GAL5)

EAI:	106838594(ST3GAL5)

MYB:	102245810(ST3GAL5)

MYD:	102759471(ST3GAL5)

MMYO:

118668784(ST3GAL5)

MLF:	102442422(ST3GAL5)

PKL:	118717621(ST3GAL5)

EFUS:

103299052(ST3GAL5)

MNA:	107528667(ST3GAL5)

DRO:	112302949(ST3GAL5)

SHON:

118982212(ST3GAL5)

AJM:	119059867(ST3GAL5)

PDIC:

114500089(ST3GAL5)

PHAS:

123811510(ST3GAL5)

MMF:	118631229(ST3GAL5)

PPAM:

129073967(ST3GAL5)

HAI:	109371317(ST3GAL5)

RFQ:	117032887(ST3GAL5)

PALE:

102879934(ST3GAL5)

PGIG:

120594581(ST3GAL5)

PVP:	105298536(ST3GAL5)

RAY:	107506062(ST3GAL5)

MJV:	108405884(ST3GAL5) 118971593

TOD:	119259137(ST3GAL5)

SARA:

101548851(ST3GAL5)

SETR:

126024498(ST3GAL5)

LAV:	100673997(ST3GAL5)

TMU:

101361139

ETF:	101646487(ST3GAL5)

DNM:	101431587(ST3GAL5)

MDO:	100029907(ST3GAL5)

SHR:	100919035(ST3GAL5)

AFZ:

127547455

PCW:	110196314(ST3GAL5)

OAA:	100080527(ST3GAL5)

GGA:	407775(ST3GAL5)

PCOC:

116225715(ST3GAL5)

MGP:	100547934(ST3GAL5)

CJO:	107314000(ST3GAL5)

TPAI:

128079831(ST3GAL5)

LMUT:

125692114(ST3GAL5)

NMEL:

110398704(ST3GAL5)

APLA:

101803297(ST3GAL5)

ACYG:

106034105(ST3GAL5)

CATA:

118248438(ST3GAL5)

AFUL:

116488990(ST3GAL5)

TGU:	100229190(ST3GAL5)

LSR:	110473300(ST3GAL5)

SCAN:

103823564(ST3GAL5)

PMOA:

120509366(ST3GAL5)

OTC:	121335112(ST3GAL5)

PRUF:

121363254(ST3GAL5)

GFR:	102038355(ST3GAL5)

FAB:	101819557(ST3GAL5)

OMA:	130252494(ST3GAL5)

PHI:	102100405(ST3GAL5)

PMAJ:

107203387(ST3GAL5)

CCAE:

111928296(ST3GAL5)

CCW:	104690804(ST3GAL5)

CBRC:

103625650(ST3GAL5)

ETL:	114058521(ST3GAL5)

ZAB:	102071310(ST3GAL5)

ACHL:

103804293(ST3GAL5)

SVG:	106865268(ST3GAL5)

MMEA:

130581169(ST3GAL5)

HRT:	120752866(ST3GAL5)

FPG:	101917839(ST3GAL5)

FCH:	102058346(ST3GAL5)

CLV:	102084795(ST3GAL5)

EGZ:	104135244(ST3GAL5)

NNI:	104018542(ST3GAL5)

PCRI:

104031858(ST3GAL5)

PLET:

104624691(ST3GAL5)

EHS:	104504416(ST3GAL5)

PCAO:

104048930(ST3GAL5)

ACUN:

113479340(ST3GAL5)

TALA:

104363197(ST3GAL5)

PADL:

103923514(ST3GAL5)

AFOR:

103907242(ST3GAL5)

ACHC:

115343163(ST3GAL5)

HALD:

104319112(ST3GAL5)

HLE:	104838083(ST3GAL5)

AGEN:

126035691

GCL:

127015598

CSTI:

104559230(ST3GAL5)

CMAC:

104475694(ST3GAL5)

MUI:	104537111(ST3GAL5)

BREG:

104642809(ST3GAL5)

FGA:	104077805(ST3GAL5)

GSTE:

104256438(ST3GAL5)

LDI:	104349716(ST3GAL5)

MNB:	103782489(ST3GAL5)

OHA:	104329614(ST3GAL5)

NNT:	104403472(ST3GAL5)

SHAB:

115610671(ST3GAL5)

DPUB:

104304847(ST3GAL5)

PGUU:

104465835(ST3GAL5)

ACAR:

104525908(ST3GAL5)

CPEA:

104391015(ST3GAL5)

AVIT:

104274692(ST3GAL5)

CVF:	104284222(ST3GAL5)

RTD:	128910435(ST3GAL5)

CUCA:

104054927(ST3GAL5)

TEO:	104380204(ST3GAL5)

BRHI:

104490503(ST3GAL5)

AAM:	106488111(ST3GAL5)

AROW:

112965547(ST3GAL5)

NPD:	112943034(ST3GAL5)

TGT:	104566071(ST3GAL5)

DNE:	112990776(ST3GAL5)

SCAM:

104151337(ST3GAL5)

ASN:	102372315(ST3GAL5)

AMJ:	102562268(ST3GAL5)

CPOO:

109322185(ST3GAL5)

GGN:	109303897(ST3GAL5)

PSS:	102453544(ST3GAL5)

CMY:	102933732(ST3GAL5)

CCAY:

125636272(ST3GAL5)

DCC:	119854676(ST3GAL5)

CPIC:

101941756(ST3GAL5)

TST:

117877626

CABI:

116829575

MRV:	120406521(ST3GAL5)

ACS:	100561853(st3gal5)

ASAO:

132771358(ST3GAL5)

PVT:	110080831(ST3GAL5)

PBI:	103065629(ST3GAL5)

PMUR:

107283194

CTIG:

120318725(ST3GAL5)

TSR:	106549664(ST3GAL5)

PGUT:

117664877(ST3GAL5)

APRI:

131199598(ST3GAL5)

PTEX:

113439476(ST3GAL5)

NSS:	113426772(ST3GAL5)

VKO:	123032414(ST3GAL5)

PMUA:

114604199(ST3GAL5)

PRAF:

128421475(ST3GAL5)

ZVI:	118079076(ST3GAL5)

HCG:	128349963(ST3GAL5)

GJA:	107116130(ST3GAL5)

STOW:

125431528(ST3GAL5)

EMC:	129325486(ST3GAL5)

XLA:	108697625(st3gal5.L) 108706512(st3gal5.S)

XTR:	100329191(st3gal5)

NPR:	108802045(ST3GAL5)

RTEM:

120924345(ST3GAL5)

BBUF:

120990425(ST3GAL5)

BGAR:

122939067(ST3GAL5)

MUO:	115461338(ST3GAL5)

GSH:	117363604(ST3GAL5)

DRE:	394230(st3gal5)

SRX:

107746174

SANH:

107677008 107677010 107688584

SGH:	107571828 107580674

CCAR:

109045093 109047824

CAUA:

113113436(st3gal5) 113114353

CGIB:

127971853 128026884

PTET:

122357592(st3gal5)

LROH:

127176416(st3gal5)

OMC:	131553419(st3gal5)

PPRM:

120494851(st3gal5)

RKG:	130085474(st3gal5)

MAMB:

125261075(st3gal5)

CIDE:

127494457

MASI:

127413326 127418155

TROS:

130551217(st3gal5)

TDW:	130438294(st3gal5)

MANU:

129422166(st3gal5)

IPU:

108269097

IFU:	128611326(st3gal5)

PHYP:

113542676(st3gal5)

SMEO:

124386518(st3gal5)

TFD:	113635947(st3gal5)

TVC:	132855894(st3gal5)

AMEX:

103033675

CMAO:

118807224(st3gal5)

EEE:

113584806

CHAR:

105913091(st3gal5)

TRU:	777948(st3gal5)

TFS:	130531842(st3gal5)

LCO:	104939171(st3gal5)

TBEN:

117475033(st3gal5)

CGOB:

115015108(st3gal5)

PGEO:

117454402(st3gal5)

GACU:

117550375(st3gal5)

EMAC:

134860020(st3gal5)

ELY:	117261196(st3gal5)

EFO:	125894471(st3gal5)

PLEP:

121948416(st3gal5)

SLUC:

116036587(st3gal5)

ECRA:

117951371(st3gal5)

ESP:	116696871(st3gal5)

PFLV:

114562610(st3gal5)

GAT:	120817074(st3gal5)

PPUG:

119210590(st3gal5)

AFB:	129090147(st3gal5)

CLUM:

117737216(st3gal5)

PSWI:

130209968(st3gal5)

MSAM:

119888660(st3gal5)

SCHU:

122880795(st3gal5)

ALAT:

119007070(st3gal5)

MZE:	101486925(st3gal5)

ONL:	100705347(st3gal5)

OAU:	116333953(st3gal5)

OLA:	101156587(st3gal5)

OML:	112153239(st3gal5)

CSAI:

133447689 133449608

XMA:	102216472(st3gal5)

XCO:	114138892(st3gal5)

XHE:	116714719(st3gal5)

PRET:

103471010(st3gal5)

PFOR:

103151708(st3gal5)

PLAI:

106934612

PMEI:

106931039

GAF:	122836795(st3gal5)

PPRL:

129362956(st3gal5)

CVG:	107094163(st3gal5)

CTUL:

119794102(st3gal5)

GMU:	124860546(st3gal5)

NFU:	107390897(st3gal5)

KMR:	108240047(st3gal5)

ALIM:

106533017

NWH:	119408572(st3gal5)

AOCE:

111580987(st3gal5)

MCEP:

125008235 125008236 125008237

CSEM:

103391463(st3gal5)

POV:	109625986(st3gal5)

SSEN:

122778864(st3gal5)

HHIP:

117768951(st3gal5)

HSP:	118111911(st3gal5)

SMAU:

118319215(st3gal5)

LCF:	108901518(st3gal5)

SDU:	111226677(st3gal5)

SLAL:

111667589

XGL:	120785328(st3gal5)

HCQ:	109515789(st3gal5)

SSCV:

125977633

SBIA:

133508805(st3gal5)

PEE:	133407383(st3gal5)

PTAO:

133484395(st3gal5)

BPEC:

110156361(st3gal5)

MALB:

109957532(st3gal5)

BSPL:

114864612(st3gal5)

SJO:	128363272(st3gal5)

STRU:

115205504(st3gal5)

OTW:	112256003(st3gal5)

OMY:	110504737(st3gal5)

OGO:	124011042(st3gal5)

ONE:	115129272(st3gal5)

OKI:	109905012(st3gal5)

OKE:	118363312(st3gal5)

SALP:

111967309(st3gal5)

SNH:	120062485(st3gal5)

CCLU:

121586712(st3gal5)

ELS:	105026834(st3gal5)

SFM:	108920350(st3gal5)

PKI:	111837711(st3gal5)

AANG:

118232380(st3gal5)

LOC:	102684259(st3gal5)

PSPA:

121325705 121331013

ARUT:

117408868 117420817

PSEX:

120527872(st3gal5)

CMK:

103181477

CPLA:

122557794 122561295(st3gal7)

HOC:	132826168(st3gal7) 132827272

LERI:

129706234(st3gal5)

PMRN:

116940511(ST3GAL5)

LRJ:	133343361(ST3GAL5)

» show all

Reference

1 [PMID:4631392]

Authors

Basu S, Kaufman B, Roseman S.

Title

Enzymatic synthesis of glucocerebroside by a glucosyltransferase from embryonic chicken brain.

Journal

J Biol Chem 248:1388-94 (1973)

Reference

2 [PMID:4022]

Authors

Fishman PH, Bradley RM, Henneberry RC.

Title

Butyrate-induced glycolipid biosynthesis in HeLa cells: properties of the induced sialyltransferase.

Journal

Arch Biochem Biophys 172:618-26 (1976)
DOI:10.1016/0003-9861(76)90116-8

Reference

3 [PMID:3838172]

Authors

Higashi H, Basu M, Basu S.

Title

Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain.

Journal

J Biol Chem 260:824-8 (1985)

Other DBs

ExplorEnz - The Enzyme Database:

2.4.3.9

IUBMB Enzyme Nomenclature:

2.4.3.9

ExPASy - ENZYME nomenclature database:

2.4.3.9

BRENDA, the Enzyme Database:

2.4.3.9

CAS:	125752-90-1

DBGET integrated database retrieval system