Entry
Name
(Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase;
waaA (gene name);
kdtA (gene name);
3-deoxy-D-manno-oct-2-ulosonic acid transferase;
3-deoxy-manno-octulosonic acid transferase;
(KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase;
CMP-3-deoxy-D-manno-oct-2-ulosonate:(Kdo)-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase;
Kdo transferase (ambiguous)
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-3-deoxy-beta-D-manno-oct-2-ulosonate:alpha-Kdo-(2->6)-[lipid IVA] 3-deoxy-D-manno-oct-2-ulosonate transferase (configuration-inverting)
Reaction(IUBMB)
CMP-beta-Kdo + an alpha-Kdo-(2->6)-[lipid IVA] = CMP + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[lipid IVA] [RN:
R05074 R06285 ]
Reaction(KEGG)
Substrate
CMP-beta-Kdo [CPD:
C04121 ];
alpha-Kdo-(2->6)-[lipid IVA] [CPD:
C06024 ]
Product
CMP [CPD:
C00055 ];
alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[lipid IVA] [CPD:
C06025 ]
Comment
The enzyme from Escherichia coli is bifunctional and transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC
2.4.99.12 [lipid IVA 3-deoxy-D-manno-octulosonic acid transferase]) [1]. The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes [2].
History
EC 2.4.99.13 created 2010, modified 2011, modified 2021
Pathway
ec00540 Lipopolysaccharide biosynthesis
Orthology
K02527 3-deoxy-D-manno-octulosonic-acid transferase
Genes
CSAT : 104734400 104768560
HSYR : 120211715 120214514
TPRA : 123902554 123904344
LJA : Lj5g3v0706550.1(Lj5g3v0706550.1) Lj5g3v0706550.2(Lj5g3v0706550.2)
CILL : 122277179 122279748
PSOM : 113293083 113309066
DOSA : Os01t0857300-01(Os01g0857300)
TAES : 123062652 123071473 123079809
ECOO : ECRM13514_4622(kdtA)
ECOH : ECRM13516_4420(kdtA)
ECW : EcE24377A_4134(waaA)
EDJ : ECDH1ME8569_3518(waaA)
ECOI : ECOPMV1_03967(waaA)
REE : electrica_00116(waaA)
RTG : NCTC13098_00134(waaA)
CLAP : NCTC11466_04536(waaA)
KIE : NCTC12125_03930(waaA)
AHN : NCTC12129_04887(kdtA)
PTF : PROFFT_A_01200(waaA)
PSHI : SAMEA2665130_2894(waaA)
YPG : YpAngola_A0061(kdtA)
YPI : YpsIP31758_0067(kdtA)
SMW : SMWW4_v1c47680(waaA)
SFJ : SAMEA4384070_4769(waaA)
SOF : NCTC11214_01625(waaA)
PAQU : DMB82_0019625(waaA)
EHD : ERCIPSTX3056_150(waaA)
TPTY : NCTC11468_03730(waaA_2)
PHEI : NCTC12003_03907(waaA)
PRJ : NCTC6933_03925(waaA)
LRI : NCTC12151_00142(waaA)
HIC : NTHIC486_00344(waaA)
HPIT : NCTC13334_00337(waaA)
HHZ : NCTC10839_00551(waaA)
HAEG : NCTC8502_00447(waaA)
PDAG : 4362423_01454(waaA)
ADP : NCTC12871_01254(waaA)
ALIG : NCTC10568_01416(waaA)
ASEG : NCTC10977_00649(waaA)
AVT : NCTC3438_00251(waaA)
RPNE : NCTC8284_00540(waaA_1) NCTC8284_00541(waaA_2)
PAET : NCTC13378_02094(waaA)
XFU : XFF4834R_chr11830(waaA)
XPH : XppCFBP6546_16870(waaA)
XHD : LMG31886_09060(waaA)
LLZ : LYB30171_00537(waaA)
VAU : VANGNB10_cI2534(kdtA_waaA?)
VPL : SA104470976_02509(kdtA)
VSA : VSAL_I0162(kdtA) VSAL_I0261
PAEB : NCGM1900_5740(waaA)
PVD : CFBP1590__4796(waaA)
PPRC : PFLCHA0_c05450(waaA)
PMUD : NCTC8068_00490(waaA)
PFW : PF1751_v1c04590(waaA)
PPUU : PputUW4_00419(waaA)
PTRT : HU722_0003365(waaA)
PTW : TUM18999_55360(waaA)
PTAE : NCTC10697_04103(waaA)
MSHE : MAALD49_07870(kdtA)
PSYC : DABAL43B_2010(kdtA)
MCAT : MC25239_01334(waaA)
MCUN : NCTC10297_01006(waaA)
SCAA : TUM17387_00550(kdtA)
PPIS : B1L02_02430 B1L02_18005
PSEN : PNC201_14520(waaA1) PNC201_17515(waaA2)
PFLI : CTT31_14765 CTT31_17775
PMAZ : R5H13_15390(waaA) R5H13_18765
CATE : C2869_10330 C2869_18380
SALH : HMF8227_00047(kdtA)
CATT : OLW01_10970 OLW01_11030(waaA)
LLG : 44548918_02022(waaA)
LJR : NCTC11533_00740(waaA)
LCJ : NCTC11976_01299(kdtA)
LWA : SAMEA4504053_2578(waaA)
LSS : NCTC12082_01191(waaA)
LADL : NCTC12735_00403(waaA)
LANT : TUM19329_07710(kdtA)
MISZ : MishRS11D_23100(waaA)
HTR : EPV75_03125 EPV75_11770
HMAR : HVMH_1892 HVMH_2254(kdtA)
TCY : Thicy_0072 Thicy_1323
TAO : THIAE_00465 THIAE_08385
THIO : AYJ59_01130 AYJ59_10680
THIG : FE785_02200 FE785_10520
TLH : NR989_02375 NR989_11360
TSE : THMIRHAS_04460(waaA)
TZO : THMIRHAT_01650(kdtA_1) THMIRHAT_05850(kdtA_2)
TFRI : Thiofri_01142(waaA)
HHK : HH1059_01440(kdtA) HH1059_10090
TNI : TVNIR_2701(waaA_[H])
GAI : IMCC3135_06865(waaA)
SEDS : AAY24_04280 AAY24_11290
THIC : TspCOW1_20720(waaA)
ALCA : ASALC70_02885(waaA_3)
NJP : NEJAP_0264 NEJAP_0802
AEL : NCTC12917_00086(kdtA)
CHJ : NCTC10426_00742(waaA)
GAP : GAPWK_2461 GAPWK_2772
ACII : C4901_00265 C4901_14585
ATY : A9R16_000255(waaA) A9R16_013470
CDIZ : CEDIAZO_00371(waaA)
NMM : NMBM01240149_0016(waaA)
NMS : NMBM01240355_0015(waaA)
NMQ : NMBM04240196_0015(waaA)
NMZ : NMBNZ0533_0016(waaA)
NMX : NMA510612_0287(kdtA)
NWE : SAMEA3174300_1768(kdtA)
NZO : SAMEA4504057_0265(waaA)
NCI : NCTC10296_00409(waaA)
NCZ : NCTC10294_01576(kdtA)
NANI : NCTC12227_02100(waaA)
ECOR : SAMEA4412678_1160(waaA)
BMV : BMASAVP1_A0719(waaA)
BML : BMA10229_A2553(waaA)
BPM : BURPS1710b_3139(kdtA)
BPL : BURPS1106A_3116(waaA)
PLG : NCTC10937_00720(kdtA)
LMIR : NCTC12852_02532(waaA)
VTR : MYVALT_G_02140(waaA)
BTRM : SAMEA390648701367(kdtA)
BBRO : BAU06_17200 BAU06_24680
BGV : CAL12_18255 CAL12_26880
AXX : ERS451415_06021(waaA)
LIM : L103DPR2_01289(waaA)
LIH : L63ED372_00872(waaA)
HYR : BSY239_2568 BSY239_2569
RBN : RBXJA2T_05668 RBXJA2T_18368
RDP : RD2015_2348 RD2015_2940
PKT : AT984_06860 AT984_08755
SULF : CAP31_02240 CAP31_03665
SPLB : SFPGR_08450 SFPGR_31400(waaA)
SNIV : SFSGTM_06800 SFSGTM_26380(kdtA)
URU : DSM104443_00057(waaA)
UPL : DSM104440_00056(waaA)
NIV : JY500_05800 JY500_17285(waaA)
AZA : AZKH_3776(kdtA_waaA)
FPHO : SHINM1_021420(kdtA)
RBS : RHODOSMS8_00183(waaA)
SMEL : SM2011_c00894(kdtA)
SFD : USDA257_c05230(waaA)
SAME : SAMCFNEI73_Ch0846(waaA)
AGR : AGROH133_04255(kdtA)
AVV : RvVAT039_22790(kdtA)
AVF : RvVAR031_10090(kdtA)
ASAL : CFBP5507_01675(waaA)
ALEG : CFBP4996_01805(waaA)
REC : RHECIAT_CH0000932(kdtA)
RLW : RlegWSM1455_02500(waaA)
NEN : NCHU2750_04030(kdtA)
LAS : CLIBASIA_01435(kdtA)
BSW : IY71_10165 IY71_12145
BSG : IY72_09905 IY72_11685
BIO : BR141012304_20737(kdtA)
VGO : GJW-30_1_00374(waaA)
BHS : BM1374165_00275(kdtA)
BBK : BARBAKC583_1204(kdtA)
BTX : BM1374166_00266(kdtA)
BEZ : NCTC12898_00156(waaA)
MAQU : Maq22A_c25765(kdtA)
BVY : NCTC9239_00791(waaA)
TSV : DSM104635_01311(waaA)
SIL : SPO2800(kdtA) SPO3444
SIT : TM1040_0723 TM1040_2641
RUA : D1823_01990 D1823_16790
RUT : FIU92_11115(waaA1) FIU92_14665(waaA2)
RDE : RD1_0293 RD1_3308(kdtA)
RLI : RLO149_c025250 RLO149_c042920
RPON : G3256_01175 G3256_06495
KVL : KVU_1197(kdtA) KVU_2299
KRO : BVG79_01441(kdtA) BVG79_02404(kdtA)
PGA : PGA1_c10190(waaA) PGA1_c33500
PGL : PGA2_c10060(waaA) PGA2_c31760
PHP : PhaeoP97_00990 PhaeoP97_03260
PPIC : PhaeoP14_00937(waaA) PhaeoP14_03148
PHQ : D1820_00855 D1820_11535
OAT : OAN307_c38220 OAN307_c47190
OAR : OA238_c08720 OA238_c41440
OTM : OSB_23430(waaA_1) OSB_26850(waaA_2) OSB_30740(waaA_3)
OCT : FTO60_12835 FTO60_12840 FTO60_15395
LMD : METH_12260 METH_19325
LEJ : ETW24_12890 ETW24_18850
LAQU : R2C4_06130 R2C4_18890
LEV : ETW23_06715 ETW23_20905
LCAE : K3721_11225 K3721_17065
CMAR : IMCC12053_1892 IMCC12053_2652 IMCC12053_2941
CEH : CEW89_11990 CEW89_17795
MALG : MALG_00656 MALG_03114
YPAC : CEW88_03360 CEW88_13940
YAN : AYJ57_10505 AYJ57_16500
TPRO : Ga0080559_TMP3223 Ga0080559_TMP663
PABY : Ga0080574_TMP1198 Ga0080574_TMP4769
SUAM : BOO69_06475 BOO69_16770
SULZ : C1J03_01835 C1J03_08525
SULI : C1J05_00400 C1J05_13435
SULD : B5M07_01920 B5M07_11095
SPOT : G6548_00960 G6548_11300
SMED : JNX03_06335 JNX03_14690
SINL : DSM14862_00386(waaA_1) DSM14862_01147(waaA_2)
SFAV : PL335_01760 PL335_05560
SUAL : KDD17_08440 KDD17_16500
SDUB : R1T39_05490 R1T39_12190
SPSE : SULPSESMR1_01892(waaA) SULPSESMR1_02986(waaA)
TOM : BWR18_08895 BWR18_15820
RMM : ROSMUCSMR3_02995(waaA)
RID : RIdsm_00095(waaA_1) RIdsm_02321(waaA_2)
ROM : EI983_06650 EI983_17130
ROH : FIU89_01030(waaA1) FIU89_12425(waaA2)
RPEL : N7U68_04920 N7U68_10960
AHT : ANTHELSMS3_02009 ANTHELSMS3_04388
SAGU : CDO87_05010 CDO87_16140
THAA : CFI11_08795 CFI11_21720
OCD : FHY55_02120 FHY55_15380
ROT : FIV09_00845(waaA1) FIV09_05910(waaA2)
MALU : KU6B_38540(kdtA1) KU6B_43140(kdtA)
TGL : HFZ77_04865 HFZ77_10800
HAT : RC74_03145 RC74_05510
PALX : GQA70_03085 GQA70_05835
LSAL : KBK07_09085 KBK07_14545
LALG : LentiSH36_00952 LentiSH36_02693
TRY : QF118_00475 QF118_16320
MARU : FIU81_09655(waaA1) FIU81_15235(waaA2)
RSP : RSP_1461(kdtA) RSP_2394(kdtA1)
RSH : Rsph17029_0112 Rsph17029_1057
RSQ : Rsph17025_0059 Rsph17025_1376
RSK : RSKD131_0709 RSKD131_2852
CAZT : LV780_00295 LV780_06190
RCP : RCAP_rcc00230(kdtA1) RCAP_rcc00647(kdtA2) RCAP_rcc00648(kdtA3)
RHP : LPB142_01770 LPB142_03625
RBL : B6K69_05240 B6K69_05245 B6K69_11920
PAMI : JCM7686_2972 JCM7686_3068
PZH : CX676_15515 CX676_17085
PARO : CUV01_03415 CUV01_05175
PARU : CYR75_03200 CYR75_14755
PAMN : JCM7685_0400 JCM7685_2581
PARS : DRW48_04670 DRW48_06640
PARR : EOJ32_05775 EOJ32_15590
PAAK : FIU66_10685 FIU66_11305
PKD : F8A10_08410 F8A10_09735
PPAN : ESD82_11320 ESD82_17445
PLIA : E4191_02655 E4191_12805
PSAN : HGN31_05220 HGN31_10520
PMAU : CP157_00489(waaA_1) CP157_02408(waaA_2)
PMEH : JWJ88_01100 JWJ88_06885
PSEW : JHW44_02900 JHW44_09420
PSAP : JHX88_01925 JHX88_16380
PFIS : JHX87_07570 JHX87_07725
PAEX : JHW48_03285 JHW48_04315
PSTL : JHW45_12860 JHW45_15485
PALP : JHW40_00420 JHW40_07085
PVER : E3U25_15950 E3U25_21235
PAEZ : PAE61_06545 PAE61_15315
PALS : PAF20_09680 PAF20_15535
PDIM : PAF18_07330 PAF18_13415
PFEO : E3U26_04590 E3U26_09505
PTP : RCA23_c00410 RCA23_c02100(waaA1) RCA23_c08950(waaA2)
RHM : B5V46_01890 B5V46_08640
RMB : K529_009725 K529_012785
TSCO : R1T40_02450 R1T40_15475
DAA : AKL17_3489 AKL17_4615
DON : BSK21_04535 BSK21_04540 BSK21_13330 BSK21_15390
RBZ : B9057_08955 B9057_08960 B9057_13115 B9057_15155
THW : BMG03_01300 BMG03_03735
TEC : AKL02_000610 AKL02_002645
LVS : LOKVESSMR4R_00714(waaA) LOKVESSMR4R_00715(waaA) LOKVESSMR4R_03753(waaA)
GEH : HYN69_00180 HYN69_04700
GFU : KM031_03945 KM031_07190
TAW : EI545_04030 EI545_04035 EI545_11990
SALO : EF888_00755 EF888_03675 EF888_04880
SEDI : EBB79_06500 EBB79_19635
PPSO : QPJ95_00435 QPJ95_08675
HML : HmaOT1_01760 HmaOT1_13635 HmaOT1_13640
PSEB : EOK75_02955 EOK75_02960 EOK75_07740
PAED : G5B38_00345 G5B38_12990
PAMO : BAR1_08365 BAR1_13865 BAR1_14865
PALW : PSAL_004720(waaA_1) PSAL_028440(waaA_2)
PSHQ : F3W81_07430 F3W81_15985
PPAF : I8N54_00350 I8N54_12190
CACT : HZ995_07220 HZ995_15670
THAS : C6Y53_05560 C6Y53_06610
CMAG : CBW24_01480 CBW24_04035
FAP : GR316_01000 GR316_07720
NSM : JO391_09225 JO391_19025
AALK : LGT41_0002130 LGT41_0002300
AMYL : QBD29_02275 QBD29_02580
PBAE : P8S53_08585 P8S53_15705
LVR : T8T21_06430 T8T21_10500
AFR : AFE_0237(kdtA) AFE_2677
AFE : Lferr_0413 Lferr_2302
AFJ : AFERRID_06380 AFERRID_11720
ATX : GCD22_00325(waaA) GCD22_03316
HCL : NCTC13205_01025(waaA)
HSH : NHP194022_02420(kdtA)
HPUL : NCTC13154_00634(waaA)
CJV : MTVDSCj20_0729(kdtA)
CFV : CFVI03293_1000(kdtA)
CAMP : CFT03427_1023(kdtA)
CCOC : CCON33237_0887(kdtA)
CLR : UPTC16701_0967(kdtA)
CLM : UPTC16712_0997(kdtA)
CAMR : CAQ16704_0991(kdtA)
CHV : CHELV3228_1179(kdtA)
CPIN : CPIN18020_0587(kdtA)
CAMZ : CVIC12175_0813(kdtA)
SMAB : LN246_01610(waaA) LN246_14155(waaA)
GBN : GEOBRER4_32840(kdtA)
DLM : DPPLL_18160(kdtA_1) DPPLL_21920(kdtA_2)
DPR : Despr_0927 Despr_2326
DEO : CAY53_00580 CAY53_11065
DOG : HP555_12625 HP555_12985
DBK : DGMP_09510(kdtA) DGMP_32950
ECOM : QTN59_03015 QTN59_05840
DTO : TOL2_C12450(waaA) TOL2_C16140(waaA2)
DWD : DSCW_15030 DSCW_15380(kdtA)
DALK : DSCA_14310(kdtA_1) DSCA_14770(kdtA_2)
DML : Dmul_19060(waaA1) Dmul_30400(waaA2)
DLI : dnl_00840(waaA) dnl_50300
DMM : dnm_060950 dnm_070800(waaA)
DAX : FDQ92_06175 FDQ92_13020
TID : Thein_0083 Thein_0152
TAV : G4V39_06745 G4V39_08875
TMAI : FVE67_00535 FVE67_07410
DHR : LGS26_01405 LGS26_02140
VRM : 44547418_00561(waaA)
VDN : NCTC11831_01401(waaA)
DHO : Dia5BBH33_02580(kdtA)
MANA : MAMMFC1_02255(waaA)
PFAC : PFJ30894_00851(waaA)
NPY : NPRO_25000 NPRO_25550
OBG : Verru16b_02297(waaA)
ABIW : Abiwalacus_13740(waaA)
LCRE : Pla8534_39850(waaA)
PLON : Pla110_19940(waaA_1) Pla110_42830(waaA_2)
UAM : UABAM_00053 UABAM_01933
FPOL : ERS445057_00452(waaA)
BTHO : Btheta7330_00331(waaA)
BCEL : BcellWH2_03393(waaA)
PCRE : NCTC12858_00081(waaA)
PCAG : NCTC12856_00062(waaA)
PMZ : HMPREF0659_A5277(waaA)
PDN : HMPREF9137_0872(waaA)
POC : NCTC13071_02495(waaA)
SMIZ : 4412673_03707(waaA)
SDJ : NCTC13534_05146(waaA)
STHA : NCTC11429_01159(waaA)
PSEZ : HME7025_01017(kdtA)
DSN : HWI92_15110 HWI92_24355
FOK : KK2020170_03100(kdtA)
PHG : KCTC32516_00969(waaA)
AALG : AREALGSMS7_02202(waaA)
KOS : KORDIASMS9_01912(waaA)
KAN : IMCC3317_36800(waaA)
SPON : HME9304_02057(kdtA)
FBU : UJ101_01810(kdtA|waaA)
CGLE : NCTC11432_02832(waaA)
CTAI : NCTC12078_02812(waaA)
CTAK : 4412677_01294(waaA)
CJG : NCTC13459_01748(waaA)
CANT : NCTC13489_01831(waaA)
PROC : Ptc2401_01610(waaA)
NLI : G3M70_07460 G3M70_07465
» show all
Taxonomy
Reference
Authors
Belunis CJ, Raetz CR
Title
Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli.
Journal
J Biol Chem 267:9988-97 (1992)
Sequence
Reference
Authors
Lobau S, Mamat U, Brabetz W, Brade H
Title
Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-alpha-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183.
Journal
Sequence
Reference
Authors
Schmidt H, Hansen G, Singh S, Hanuszkiewicz A, Lindner B, Fukase K, Woodard RW, Holst O, Hilgenfeld R, Mamat U, Mesters JR.
Title
Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.99.13