KEGG   ENZYME: 2.4.99.21
Entry
EC 2.4.99.21                Enzyme                                 
Name
dolichyl-phosphooligosaccharide-protein glycotransferase;
AglB;
archaeal oligosaccharyl transferase;
dolichyl-monophosphooligosaccharide-protein glycotransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
Sysname
dolichyl-phosphooligosaccharide:protein-L-asparagine N-beta-D-oligosaccharidotransferase
Reaction(IUBMB)
an archaeal dolichyl phosphooligosaccharide + [protein]-L-asparagine = an archaeal dolichyl phosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine
Substrate
archaeal dolichyl phosphooligosaccharide;
[protein]-L-asparagine
Product
archaeal dolichyl phosphate [CPD:C21212];
glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine
Comment
The enzyme, characterized from the archaea Methanococcus voltae and Haloferax volcanii, transfers a glycan component from dolichyl phosphooligosaccharide to external proteins. It is different from EC 2.4.99.18, dolichyl-diphosphooligosaccharide-protein glycotransferase, which uses dolichyl diphosphate as carrier compound in bacteria and eukaryotes. The enzyme participates in the N-glycosylation of proteins in some archaea. It requires Mn2+. Dolichol used by archaea is different from that used by eukaryotes. It is much shorter (C55-C60), it is alpha,omega-saturated and it may have additional unsaturated positions in the chain.
History
EC 2.4.99.21 created 2015
Orthology
K21306  dolichyl-phosphooligosaccharide-protein glycotransferase
Genes
GEOGeob_1424 Geob_2990
DLIdnl_42750
SURSTAUR_5887
AGEAA314_03686
AVMJQX13_32570
CFUSCYFUS_005592
MTAUJS510_00660
VAIBU251_01235
CTMCabther_A0306
CVLJ8C06_02030
CHLOJ8C02_01495
MJAMJ_1525
MFEMefer_0590
MVUMetvu_0243
MFSMFS40622_0538
MIFMetin_1222
MJHJH146_0370
MESGMLAUSG7_0298(aglB)
MESAMLASG1_1379(aglB)
MIGMetig_1797
MMPMMP1424
MMQMmarC5_0154
MMXMmarC6_1249
MMZMmarC7_0669
MMDGYY_07955
MMAKMMKA1_16480
MMAOMMOS7_15310
MMADMMJJ_14150
MAEMaeo_1409
MVNMevan_0735
MVOMvol_1038
MOKMetok_0791
METFCFE53_03490
MTHMTH_1623 MTH_1898 MTH_1906
MMGMTBMA_c02090 MTBMA_c04670
MWOMWSIV6_0169(stt3) MWSIV6_0430 MWSIV6_0432(aglB) MWSIV6_0805
MTEEMTTB_11640 MTTB_13750
METCMTCT_1482 MTCT_1729 MTCT_1730
METEtca_01572(pglB_2) tca_01834 tca_01844(pglB_3)
METZMETMT2_0226 METMT2_1463
METKFVF72_00310 FVF72_02210 FVF72_02215 FVF72_03505
MTHMFZP57_00735 FZP57_02025 FZP57_02030 FZP57_03850
METJFZP68_05750 FZP68_07045 FZP68_07050
MSTMsp_0368
METBAW729_05230
MEISPXD04_05650
MRUmru_0391
MSIMsm_0716
MEBAbm4_0186
MMILsm9_2154
MEYETL18_01100
MOLYLM1_0063
MAROMarbSA_10000
METVK4897_04125
MELMetbo_0534 Metbo_0719
MEWMSWAN_1515 MSWAN_1516 MSWAN_1855
METHMBMB1_1244 MBMB1_1488
MFCBRM9_0454 BRM9_0715
MFIDSM1535_0382 DSM1535_0667
MCUBMCBB_1451 MCBB_1452(aglB_1) MCBB_1453(aglB_3) MCBB_1727
MSUBBK009_06390
METNBK008_00625 BK008_01980
METTCIT01_06795 CIT01_08560 CIT01_08565
METOCIT02_10590 CIT02_11860
MEMEHYG87_07520 HYG87_09010
MFEGGCM10025860_25800 GCM10025860_28970
MFVMfer_0177 Mfer_0275 Mfer_0623
AFUAF_0040 AF_0380
AFGAFULGI_00003280 AFULGI_00003800
APOArcpr_0726 Arcpr_1194
AVEArcve_0568
ASTAsulf_01983
FPLFerp_2437
GACGACE_1401
GAHGAH_01455
PFUPF0156 PF0411
PFIPFC_01140 PFC_07420
PHOPH0242(PH0242) PH1271(PH1271)
PABPAB1586 PAB2202
PYNPNA2_0761 PNA2_1113
PYAPYCH_17920 PYCH_19200
PYSPy04_0309 Py04_0456
PYCTQ32_00625 TQ32_01355
TKOTK0810 TK1718
TONTON_0775 TON_1820
TGATGAM_0406 TGAM_0937
TSITSIB_0007 TSIB_0418
TBATERMP_00665 TERMP_02078 TERMP_02121
THEGQS_01010 GQS_05995 GQS_06090
THATAM4_1026 TAM4_672
THMCL1_0839 CL1_0859 CL1_1904
TLTOCC_09883 OCC_13840 OCC_13845
THSTES1_0603 TES1_2025
TNUBD01_0960 BD01_1483
TEUTEU_03805 TEU_10605
TGYX802_05945 X802_10390
THVADU37_CDS03470 ADU37_CDS21770
TCHCHITON_0376 CHITON_0533
TPEPA0127_01040 A0127_06605
TPIEA7C91_10070
TGGA3K92_05705
TCEA3L02_01695 A3L02_08450
TBSA3L01_04670 A3L01_10285
THHCDI07_00005 CDI07_04540
TSLA3L11_03485 A3L11_03600 A3L11_08810
TTDA3L14_01205 A3L14_06640
TPRFA3L09_06860 A3L09_10205 A3L09_10300
TRLA3L10_01955 A3L10_09685
TPAFA3L08_07280
THYA3L12_02835 A3L12_07965
TICFH039_01740 FH039_08440
TCQTIRI35C_0153 TIRI35C_0174 TIRI35C_1192
THEMFPV09_01110 FPV09_07665
THEIK1720_05200
PPACPAP_06870 PAP_09855
MBAMbar_A0242 Mbar_A0243 Mbar_A0368
MBYMSBRM_0550 MSBRM_2711 MSBRM_2714 MSBRM_2715
MBWMSBRW_0630 MSBRW_0752 MSBRW_0753
MBARMSBR2_1828 MSBR2_2667 MSBR2_2668 MSBR2_2669
MBAKMSBR3_2756 MSBR3_2757 MSBR3_2758 MSBR3_2759 MSBR3_2884
MACMA_1172 MA_3752 MA_3753
MMAMM_0647 MM_2210
MMAZMmTuc01_0661 MmTuc01_2261
MMJMSMAS_0662 MSMAS_0663 MSMAS_2483
MMACMSMAC_0664 MSMAC_0665 MSMAC_1961
MVCMSVAZ_0691 MSVAZ_0693 MSVAZ_3027
MEKMSKOL_0669 MSKOL_0670 MSKOL_3009
MLSMSLAZ_0721 MSLAZ_2435
METMMSMTP_0730 MSMTP_0868
MEFMSWH1_0825 MSWH1_2215
MEQMSWHS_0883 MSWHS_2866
MSJMSSAC_1266 MSSAC_3560 MSSAC_3561 MSSAC_3562
MSZMSSIH_2848 MSSIH_3102 MSSIH_3103 MSSIH_3104
MSWMSSIT_2883 MSSIT_3159 MSSIT_3160 MSSIT_3161
MTHRMSTHT_2372 MSTHT_2373 MSTHT_2469
MTHEMSTHC_0813 MSTHC_0907 MSTHC_0908
MHORMSHOH_0783 MSHOH_0784 MSHOH_0785 MSHOH_3118
MFZAOB57_003075 AOB57_003555 AOB57_003560
MBUMbur_1579
MMETMCMEM_2091
MELOJ7W08_09420
MMHMmah_0123
MHAZBHR79_02840
MPOTBKM01_05460
MEVMetev_1257
MZHMzhil_1653
MPYMpsy_2355
MZIHWN40_06640 HWN40_10570
MMAVRE476_12710
MSEBRE474_09440 RE474_09780
MHZMetho_0214 Metho_0482
MEHFMmiHf6_15040
MEESMmiEs2_12260
MTPMthe_1164 Mthe_1498
MCJMCON_1133 MCON_1444
MHIMhar_0540 Mhar_1091 Mhar_1439 Mhar_1730
MHUMhun_2859 Mhun_3138
MRTJKHC33_01570 KHC33_02655 KHC33_16045
MLAMlab_0662
MEMMemar_0175 Memar_2235
MBGBN140_1425
MEMAMMAB1_1829
MCHKMchiMG62_25530 MchiMG62_25540
MSUMOH143_05460 OH143_07655
MRCR6Y96_03705
MPIMpet_0084 Mpet_2443
MEFWF1737_10575
MFKE2N92_07215
MOUOU421_07675
MESBL1S32_11060
MANQL1994_10565 L1994_11805
MBNMboo_0249 Mboo_1209
MFOMetfor_0235 Metfor_0449 Metfor_2864
MPLMpal_0785
MPDMCP_2705 MCP_2723
MEZMtc_0182 Mtc_0183 Mtc_0205
RCILRC539 LRC558
HALVNG_1068G(tot)
HSLOE_2548F(aglB)
HANRLJ422_04380
HDLHALDL1_10975
HHBHhub_1167 Hhub_2271(aglB)
HAGSJT689_05635
HABOJRZ79_04100
HNOLT974_07075
HLULT972_06890
HALHHTSR_0845(aglB)
HHSRHSR6_0872(aglB)
HSUHLASF_1520(aglB)
HSFHLASA_1507(aglB)
HAHSHSRCO_1860(aglS)
SALRFQU85_09050
HALREFA46_009405
HJEHacjB3_10630
HDOMUK72_10570
HALXM0R89_17325
HAXZM0R88_17615
HAYCNGM10_15075
HAXYNGM07_03725
SALIL593_04990
SAIMK0C01_09230
HARAAArcS_1839(aglS2)
HMArrnAC0431(tot)
HHIHAH_1202(stt3)
HHNHISP_06150
HABSG26_13800
HTABVU17_05845
HALJG9465_10525
HSINKDQ40_07485
NPHNP_3720A(aglB)
NMONmlp_2363(aglB)
NHOHWV23_01680
NSALHWV07_01780
HUTHuta_2131 Huta_2808
HTIHTIA_0988 HTIA_2714
HALAHrd1104_03925
HASVSVXHr_1767(aglB)
HABNHBNXHr_1755(aglB)
HMUHmuk_2752
HALZE5139_01055
HALLLC1Hm_2096(aglB)
HAZPGBQ70_01055
HALIBV210_00425
HSNDV733_10970 DV733_14250 DV733_16010
HDSHSR122_1829(aglS)
HRRHZS55_05895 HZS55_17075
HPELHZS54_11250 HZS54_20445
HLTI7X12_18565
HARCHARCEL1_10660
SSAIN0B31_08725
HAADMW046_02035 MW046_17750
HWAHQ_2681A(aglB)
HWCHqrw_3013(aglB) Hqrw_3360
HVOHVO_1530(aglB)
HMEHFX_1592(stt3)
HGIABY42_07445
HALEG3A49_10770
HLSKU306_12730
HLNSVXHx_1476(aglb) SVXHx_3241(aglb)
HBOHbor_17000
HAQDU484_07450 DU484_15375
HAJDU500_15395
HAERDU502_05710 DU502_13475
HRAEI982_08080 EI982_08355 EI982_17700
HLMDV707_04230
HALMFCF25_14555
HLAHlac_1062
HALPDOS48_05360
HALBEKH57_05760
HEZZEO776_06735
HALQHrr1229_001115 Hrr1229_001220
HSSJ7656_09935
HSAIHPS36_00285
HAZZKI388_04265
SRUBC2R22_09340 C2R22_20965
HAEhalTADL_2411
HALNB4589_014265
HALGHUG10_00440
HALUHUG12_17320
HMPK6T50_14730
HREK6T36_14685
HRMK6T25_02065
HACBHbl1158_06790
HDFAArcSl_2614(aglB2)
HAHHalar_1620
HTUHtur_2957
HSALJMJ58_13645
HAKZJ0X25_01415
NMGNmag_0927(aglB)
HXAHalxa_2340
NATNJ7G_1722
NPENatpe_1007
NVRFEJ81_05205
NPLFGF80_05650
NAYHYG81_05440
HALYHYG82_08425
HJTDVR14_14335 DVR14_18215 DVR14_22345
HLOJ0X27_11635
NGENatgr_2245
HRUHalru_0989
SAWLNGM29_06990
NOUNatoc_2649
HLRHALLA_07255
HLCCHINAEXTREME09050
NAJB1756_14500
NAGAArcMg_2847
NANAArc1_0855
NARAQQ977_11745
NBGDV706_10780
NASGCU68_01300
HDABB347_08850
NACAQV86_00615
MEAMMU439_01745
TACTa1136
TVOTVG1271204(TVG1271204)
PTOPTO0786
FACFACI_IFERC01G1211
FAIFAD_0235
CDIVCPM_1322
TARTALC_01514
MAXMMALV_16370
MERMMINT_19550
MEARMpt1_c13780(aglB)
MEUZKRP56_00005
MARCAR505_0061
ABIAboo_0310
ACFAciM339_0753
MARHMia14_0132
FLTSv326_1310
MIYMicr_00082 Micr_00288
NCONLC1Nh_1167(stt3)
AGWQT03_C0001G0537
ARGQT11_C0001G0576
 » show all
Reference
1  [PMID:16824110]
  Authors
Chaban B, Voisin S, Kelly J, Logan SM, Jarrell KF
  Title
Identification of genes involved in the biosynthesis and attachment of Methanococcus voltae N-linked glycans: insight into N-linked glycosylation pathways in Archaea.
  Journal
Mol Microbiol 61:259-68 (2006)
DOI:10.1111/j.1365-2958.2006.05226.x
  Sequence
Reference
2  [PMID:23624439]
  Authors
Larkin A, Chang MM, Whitworth GE, Imperiali B
  Title
Biochemical evidence for an alternate pathway in N-linked glycoprotein biosynthesis.
  Journal
Nat Chem Biol 9:367-73 (2013)
DOI:10.1038/nchembio.1249
  Sequence
Reference
3  [PMID:24212570]
  Authors
Cohen-Rosenzweig C, Guan Z, Shaanan B, Eichler J
  Title
Substrate promiscuity: AglB, the archaeal oligosaccharyltransferase, can process  a variety of lipid-linked glycans.
  Journal
Appl Environ Microbiol 80:486-96 (2014)
DOI:10.1128/AEM.03191-13
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.21
IUBMB Enzyme Nomenclature: 2.4.99.21
ExPASy - ENZYME nomenclature database: 2.4.99.21
BRENDA, the Enzyme Database: 2.4.99.21

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