Entry
Name
lipopolysaccharide heptosyltransferase I;
HepI;
rfaC (gene name);
WaaC;
heptosyltransferase I (ambiguous)
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
ADP-L-glycero-beta-D-manno-heptose:an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[lipid A] 5-alpha-heptosyltransferase
Reaction(IUBMB)
ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[lipid A] = ADP + an alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] [RN:
R13003 ]
Reaction(KEGG)
Substrate
ADP-L-glycero-beta-D-manno-heptose [CPD:
C06398 ];
alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A [CPD:
C06026 ]
Product
ADP [CPD:
C00008 ];
alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A]
Comment
The enzyme catalyses a glycosylation step in the biosynthesis of the inner core oligosaccharide of the lipopolysaccharide (endotoxin) of many Gram-negative bacteria.
History
EC 2.4.99.23 created 2022
Orthology
K02841 lipopolysaccharide heptosyltransferase I
Genes
ECOO : ECRM13514_4612(rfaC)
ECOH : ECRM13516_4410(rfaC)
ECW : EcE24377A_4124(rfaC)
EDJ : ECDH1ME8569_3506(rfaC)
ECOI : ECOPMV1_03956(rfaC)
REE : electrica_00126(rfaC)
RTG : NCTC13098_00146(rfaC)
CLAP : NCTC11466_04527(rfaC)
KIE : NCTC12125_03940(rfaC)
AHN : NCTC12129_04879(rfaC)
METY : MRY16398_01300(waaC)
PTF : PROFFT_A_02750(rfaC)
PSHI : SAMEA2665130_2884(rfaC)
YPG : YpAngola_A0062(rfaC)
YPI : YpsIP31758_0068(rfaC)
SMW : SMWW4_v1c47580(rfaC)
SFJ : SAMEA4384070_4760(rfaC)
SOF : NCTC11214_01615(rfaC)
PAQU : DMB82_0019555(rfaC)
DIC : Dpoa569_003759(rfaC)
EHD : ERCIPSTX3056_560(rfaC)
TPTY : NCTC11468_03718(rfaC)
PHEI : NCTC12003_03905(rfaC)
PRJ : NCTC6933_03923(rfaC)
HPIT : NCTC13334_00697(rfaC)
HHZ : NCTC10839_00253(rfaC)
PDAG : 4362423_01994(rfaC)
ALIG : NCTC10568_01799(rfaC_2)
AVT : NCTC3438_00417(rfaC)
PAET : NCTC13378_02016(rfaC)
PAEB : NCGM1900_5763(waaC)
PVD : CFBP1590__4817(rfaC)
PPRC : PFLCHA0_c05210(rfaC)
PMUD : NCTC8068_00470(rfaC)
PFW : PF1751_v1c04370(rfaC)
PPUU : PputUW4_00398(rfaC)
PTRT : HU722_0003225(waaC)
PTW : TUM18999_55590(waaC)
PTAE : NCTC10697_04124(rfaC)
MISZ : MishRS11D_04260(waaC)
TIB : THMIRHAM_17340(waaC)
TSE : THMIRHAS_19960(waaC1)
TFRI : Thiofri_01133(rfaC)
ALCA : ASALC70_02806(rfaC)
TWAN : HUF19_01125(waaC) HUF19_07805(waaC)
GBI : PG2T_04095 PG2T_13370
NMM : NMBM01240149_2054(rfaC)
NMS : NMBM01240355_2090(rfaC)
NMZ : NMBNZ0533_2082(rfaC)
NMX : NMA510612_0263(rfaC)
NWE : SAMEA3174300_1758(rfaC)
NZO : SAMEA4504057_0282(rfaC)
NCI : NCTC10296_00676(rfaC)
NCZ : NCTC10294_01558(rfaC)
NANI : NCTC12227_02004(rfaC)
ECOR : SAMEA4412678_0967(rfaC)
DEE : HQN60_06780(waaC) HQN60_07935(waaC)
DTK : K4H28_00500(waaC) K4H28_15975(waaC)
CHIZ : HQ393_11905(waaC) HQ393_15915(waaC)
RSO : RSc0692(rfaC1) RSp0634(rfaC2)
RPU : CDC45_03580(waaC) CDC45_20790(waaC)
RNC : GO999_13125(waaC) GO999_17215(waaC)
RSL : RPSI07_2658(rfaC) RPSI07_mp0517(rfaC)
RSN : RSPO_c02677(rfaC) RSPO_m00981(rfaC2)
RSM : CMR15_30227(rfaC) CMR15_mp10586(rfaC)
RSY : RSUY_09090(rfaC_1) RSUY_38460(rfaC_2)
RPJ : N234_04230 N234_16535
REH : H16_A0905(rfaF2) H16_A2884(rfaF1)
CNC : CNE_1c08530(rfaF2) CNE_1c28220(rfaF3)
RME : Rmet_2224(rfaC) Rmet_2715(rfaC)
CTI : RALTA_A0816(rfaC2) RALTA_A2363(rfaC1)
CBW : RR42_m2789 RR42_m3196
CGD : CR3_0521(waaC) CR3_1783(waaC)
CPAU : EHF44_00210(waaC) EHF44_09340(waaC) EHF44_11625(waaC)
COX : E0W60_14670(waaC) E0W60_23575(waaC)
CCAM : M5D45_10885(waaC) M5D45_12785(waaC)
CCAX : KZ686_06850(waaC) KZ686_13615(waaC)
CUK : KB879_04465(waaC) KB879_26585(waaC)
CNAN : A2G96_05275 A2G96_18210
BMA : BMA2108(rfaC) BMA2190(waaC)
BMV : BMASAVP1_A0717(waaC) BMASAVP1_A0804(rfaC)
BML : BMA10229_A2551(rfaC_1) BMA10229_A2636(rfaC_2)
BMN : BMA10247_1976(rfaC_2) BMA10247_2063(rfaC_1)
BMAL : DM55_2274(rfaC) DM55_2350(rfaC)
BMAE : DM78_889(rfaC) DM78_965(rfaC)
BMAQ : DM76_2258(rfaC) DM76_2334(rfaC)
BMAF : DM51_1764(waaC) DM51_1840(waaC)
BMAZ : BM44_1164(rfaC) BM44_1242(rfaC)
BMAB : BM45_730(waaC) BM45_807(waaC)
BPS : BPSL2592(waaC2) BPSL2665(waaC1)
BPM : BURPS1710b_3061(rfaC) BURPS1710b_3141(rfaC)
BPL : BURPS1106A_3028(rfaC) BURPS1106A_3118(rfaC)
BPD : BURPS668_2963(rfaC) BURPS668_3082(rfaC)
BPR : GBP346_A3167(rfaC_1) GBP346_A3262(rfaC_2)
BPSE : BDL_2781(rfaC) BDL_2858(rfaC)
BPSM : BBQ_648(rfaC) BBQ_725(rfaC)
BPSU : BBN_776(rfaC) BBN_853(rfaC)
BPSD : BBX_1180(rfaC) BBX_1257(rfaC)
BPZ : BP1026B_I0654(waaC1) BP1026B_I0732(waaC2)
BPQ : BPC006_I3066 BPC006_I3162
BPK : BBK_2279(rfaC) BBK_2362(rfaC)
BPSH : DR55_1854(rfaC) DR55_1930(rfaC)
BPSA : BBU_2899(rfaC) BBU_2976(rfaC)
BPSO : X996_1495(rfaC) X996_1577(rfaC)
BUT : X994_3494(waaC) X994_3571(waaC)
BTE : BTH_I1490(rfaC-1) BTH_I1574(rfaC-2)
BTQ : BTQ_2346(rfaC) BTQ_2432(rfaC)
BTJ : BTJ_3233(rfaC) BTJ_3338(rfaC)
BTZ : BTL_1163(rfaC) BTL_1248(rfaC)
BTD : BTI_1032(rfaC) BTI_941(rfaC)
BTV : BTHA_1256(rfaC) BTHA_1360(rfaC)
BTHE : BTN_141(rfaC) BTN_224(rfaC)
BTHM : BTRA_1372(rfaC) BTRA_1477(rfaC)
BTHL : BG87_1386(waaC) BG87_1473(waaC)
BOK : DM82_2214(rfaC) DM82_2327(rfaC)
BOC : BG90_2408(waaC) BG90_2498(waaC)
BUU : WS70_12990 WS70_13545
BSAV : WS86_04940 WS86_05330
BHG : I6G56_15510(waaC) I6G56_15985(waaC)
BUD : AQ610_04570 AQ610_05035
BVI : Bcep1808_0827 Bcep1808_0906
BVE : AK36_2953(waaC) AK36_3033(waaC)
BUR : Bcep18194_A4000 Bcep18194_A4092
BCM : Bcenmc03_0864 Bcenmc03_0949
BCH : Bcen2424_0894 Bcen2424_0989
BCJ : BCAL3022 BCAL3112(waaC)
BCEN : DM39_707(rfaC) DM39_816(rfaC)
BCEW : DM40_1565(rfaC) DM40_1643(rfaC)
BCEO : I35_0761(waaC) I35_0847
BAC : BamMC406_0784 BamMC406_0861
BMJ : BMULJ_00740(waaC) BMULJ_00824(waaC)
BMK : DM80_711(rfaC) DM80_782(rfaC)
BMUL : NP80_1077(waaC) NP80_901(waaC)
BCED : DM42_851(rfaC) DM42_934(rfaC)
BCEP : APZ15_08205 APZ15_08610
BDL : AK34_2192(waaC) AK34_2274(waaC)
BPYR : ABD05_10100 ABD05_10510
BCON : NL30_10875 NL30_11275
BUB : BW23_752(waaC) BW23_832(waaC)
BDF : WI26_04005 WI26_04395
BLAT : WK25_04190 WK25_04630
BTEI : WS51_14750 WS51_15155
BSEM : WJ12_04090 WJ12_04530
BPSL : WS57_21880 WS57_22450
BMEC : WJ16_04120 WJ16_04555
BSTG : WT74_04400 WT74_04840
BSTL : BBJ41_07255 BBJ41_07675
BANN : JFN94_04305(waaC) JFN94_04720(waaC)
BARI : NLX30_04400(waaC) NLX30_04885(waaC)
BAEN : L3V59_04380(waaC) L3V59_04845(waaC)
BUG : BC1001_0693 BC1001_0809
BGF : BC1003_0803 BC1003_0909
BYI : BYI23_A020340 BYI23_B004300
BUE : BRPE67_ACDS20970 BRPE67_BCDS06920
BUL : BW21_1034(waaC) BW21_1125(waaC)
BUQ : AC233_03450 AC233_17510
BUM : AXG89_01790 AXG89_17185
BUI : AX768_11535 AX768_26905
BURK : DM992_16720(waaC) DM992_17140(waaC)
BXB : DR64_1120(rfaC) DR64_1392(rfaC)
BGE : BC1002_0656 BC1002_0766
BPX : BUPH_05376 BUPH_05522
BPY : Bphyt_0921 Bphyt_1060
BUZ : AYM40_03505 AYM40_04595
BFN : OI25_672(waaC) OI25_794(waaC)
BCAI : K788_0003265 K788_0007858
PSPW : BJG93_08905(waaC) BJG93_09560(waaC)
PARA : BTO02_07070 BTO02_07240 BTO02_16200
PARB : CJU94_00895(waaC) CJU94_01575(waaC)
PHS : C2L64_03650(waaC) C2L64_12710(waaC)
PTER : C2L65_03475(waaC) C2L65_11815(waaC)
PGP : CUJ91_03660(waaC) CUJ91_17445(waaC)
PCJ : CUJ87_03665(waaC) CUJ87_04225(waaC)
PTS : CUJ90_03380(waaC) CUJ90_03965(waaC)
PMEG : FNZ07_18400(waaC) FNZ07_28440(waaC)
PTRO : G5S35_03235(waaC) G5S35_10775(waaC)
PGIS : I6I06_07760(waaC) I6I06_08345(waaC)
PACP : FAZ97_03395(waaC) FAZ97_10570(waaC)
PACS : FAZ98_03210(waaC) FAZ98_04110(waaC)
PEW : KZJ38_05980(waaC) KZJ38_15930(waaC) KZJ38_16130(waaC)
PDIO : PDMSB3_0812(rfaC) PDMSB3_0960
PBRY : NDK50_03635(waaC) NDK50_04340(waaC)
PSAA : QEN71_03540(waaC) QEN71_25405(waaC)
PKF : RW095_39105(waaC) RW095_39710(waaC)
PBON : QS306_04585(waaC) QS306_10695(waaC)
PPAI : E1956_07070(waaC) E1956_14755(waaC)
BRH : RBRH_00221 RBRH_01443(waaC)
PLG : NCTC10937_00692(rfaC)
LMIR : NCTC12852_02101(rfaC)
CABA : SBC2_27890(rfaC_1) SBC2_64620(rfaC_2)
BUO : BRPE64_ACDS21380(waaC) BRPE64_BCDS08900
CABK : NK8_21360(waaC) NK8_37480(waaC)
VTR : MYVALT_G_02120(rfaC)
TVL : FAZ95_17145(waaC) FAZ95_21975(waaC)
TCAR : U0034_04965(waaC) U0034_15095(waaC)
BTRM : SAMEA390648701366(rfaC)
AXX : ERS451415_06022(rfaC)
RHY : RD110_14355 RD110_14360
THI : THI_1200(rfaC) THI_1242
URU : DSM104443_00058(rfaC)
UPL : DSM104440_00057(rfaC)
QAU : KI612_04680 KI612_18620(waaC)
AZO : azo2321(waaC1) azo3566(waaC2)
AZA : AZKH_0595(waaC_rfaC)
AZR : CJ010_14880 CJ010_21590(waaC)
ACOM : CEW83_17565 CEW83_17605 CEW83_17840(waaC)
FPHO : SHINM1_021430(rfaC)
VGO : GJW-30_1_02193(rfaC)
HPO : HMPREF4655_20521(rfaC)
HPX : HMPREF0462_0332(rfaC)
HCL : NCTC13205_00711(waaC)
HSH : NHP194022_03950(rfaC)
HPUL : NCTC13154_00680(rfaC)
CJV : MTVDSCj20_1136(waaC)
CFV : CFVI03293_1437(waaC)
CAMP : CFT03427_1362(waaC)
CCOC : CCON33237_1504(waaC)
CLR : UPTC16701_1230(waaC)
CLM : UPTC16712_1248(waaC)
CAMR : CAQ16704_1258(waaC)
CHV : CHELV3228_0547(waaC)
CPIN : CPIN18020_1341(waaC)
CAMZ : CVIC12175_0225(waaC)
GEF : FO488_03060(waaC) FO488_03070(waaC)
DMM : dnm_055040 dnm_085500
VRM : 44547418_00768(rfaF_3)
VDN : NCTC11831_01189(rfaQ_2)
DHO : Dia5BBH33_09710(rfaF)
MANA : MAMMFC1_02280(rfaQ_2)
PFAC : PFJ30894_00056(rfaC)
NPY : NPRO_08570 NPRO_08580
LCRE : Pla8534_35790(rfaC)
SDYN : Mal52_39240(rfaF_1)
PLON : Pla110_29020(rfaF_1)
HBS : IPV69_01305(waaC) IPV69_10380
ABAC : LuPra_05050(rfaQ_2)
MSIL : METEAL_13660(waaF_1)
NNEO : PQG83_03700 PQG83_11250
» show all
Taxonomy
Reference
Authors
Kadrmas JL, Raetz CR.
Title
Enzymatic synthesis of lipopolysaccharide in Escherichia coli. Purification and properties of heptosyltransferase i.
Journal
Reference
Authors
de Kievit TR, Lam JS.
Title
Isolation and characterization of two genes, waaC (rfaC) and waaF (rfaF), involved in Pseudomonas aeruginosa serotype O5 inner-core biosynthesis.
Journal
Sequence
Reference
Authors
Klena JD, Gray SA, Konkel ME.
Title
Cloning, sequencing, and characterization of the lipopolysaccharide biosynthetic enzyme heptosyltransferase I gene (waaC) from Campylobacter jejuni and Campylobacter coli.
Journal
Sequence
Reference
Authors
Gronow S, Oertelt C, Ervela E, Zamyatina A, Kosma P, Skurnik M, Holst O.
Title
Characterization of the physiological substrate for lipopolysaccharide heptosyltransferases I and II.
Journal
J Endotoxin Res 7:263-70 (2001)
Reference
Authors
Grizot S, Salem M, Vongsouthi V, Durand L, Moreau F, Dohi H, Vincent S, Escaich S, Ducruix A.
Title
Structure of the Escherichia coli heptosyltransferase WaaC: binary complexes with ADP and ADP-2-deoxy-2-fluoro heptose.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.99.23