Entry
Name
lipopolysaccharide heptosyltransferase II;
HepII;
rfaF (gene name);
WaaF;
heptosyltransferase II
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
ADP-L-glycero-beta-D-manno-heptose:an alpha-L-glycero-D-manno-heptosyl-(1->5)-[alpha-Kdo-(2->4)]-alpha -Kdo-(2->6)-[lipid A] 3-alpha-heptosyltransferase
Reaction(IUBMB)
ADP-L-glycero-beta-D-manno-heptose + an alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] = ADP + an alpha-Hep-(1->3)-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A] [RN:
R13004 ]
Reaction(KEGG)
Substrate
ADP-L-glycero-beta-D-manno-heptose [CPD:
C06398 ];
alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A]
Product
ADP [CPD:
C00008 ];
alpha-Hep-(1->3)-alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[lipid A]
Comment
The enzyme catalyses a glycosylation step in the biosynthesis of the inner core oligosaccharide of the lipopolysaccharide (endotoxin) of some Gram-negative bacteria.
History
EC 2.4.99.24 created 2022
Orthology
K02843 lipopolysaccharide heptosyltransferase II
Genes
ECOO : ECRM13514_4611(rfaF)
ECOH : ECRM13516_4409(rfaF)
ECW : EcE24377A_4123(rfaF)
EDJ : ECDH1ME8569_3505(rfaF)
ECOI : ECOPMV1_03955(rfaF)
REE : electrica_00127(rfaF_2)
RTG : NCTC13098_00147(rfaF)
CLAP : NCTC11466_04526(rfaF)
KIE : NCTC12125_03941(rfaF)
AHN : NCTC12129_04878(rfaF)
YRE : HEC60_17030 HEC60_17355(rfaF)
PTF : PROFFT_A_02760(rfaF)
PSHI : SAMEA2665130_2883(rfaF)
YPG : YpAngola_A0063(rfaF)
YPI : YpsIP31758_0069(rfaF)
SMW : SMWW4_v1c47570(rfaF)
SFJ : SAMEA4384070_4759(rfaF)
SOF : NCTC11214_01614(rfaF_1)
EAME : GXP68_11740 GXP68_20785(rfaF)
PAQU : DMB82_0019550(rfaF)
DIC : Dpoa569_003758(rfaF)
EHD : ERCIPSTX3056_559(rfaF)
PLF : PANA5342_0148(rfaF3)
TPTY : NCTC11468_03717(rfaF)
PPEE : I6G31_09440(rfaF) I6G31_09510
PHEI : NCTC12003_03904(rfaF)
PRJ : NCTC6933_03922(rfaF)
LRI : NCTC12151_00144(rfaF)
HIC : NTHIC486_01688(rfaF)
HPIT : NCTC13334_00699(rfaF)
HHZ : NCTC10839_00256(rfaF)
HAEG : NCTC8502_01239(rfaF)
PDAG : 4362423_01995(rfaF)
ADP : NCTC12871_00680(rfaF)
ALIG : NCTC10568_01800(rfaF)
ASEG : NCTC10977_00376(rfaF)
AVT : NCTC3438_00416(rfaF)
RPNE : NCTC8284_00078(rfaF_1)
PAET : NCTC13378_02017(rfaF)
VPL : SA104470976_02507(rfaF_1)
VSA : VSAL_I0161(rfaF) VSAL_I0262
PAEB : NCGM1900_5764(waaF)
PVD : CFBP1590__4818(rfaF)
PPRC : PFLCHA0_c05200(rfaF)
PMUD : NCTC8068_00469(rfaF)
PFW : PF1751_v1c04360(rfaF)
PPUU : PputUW4_00397(rfaF)
PTRT : HU722_0003220(waaF)
PTW : TUM18999_55600(waaF)
PTAE : NCTC10697_04125(rfaF)
MSHE : MAALD49_07760(rfaF)
HJA : BST95_02490 BST95_04885
HALC : EY643_00300(waaF) EY643_17360(waaF)
CBS : COXBURSA331_A1852(rfaF)
LLG : 44548918_00060(rfaF)
LCJ : NCTC11976_00916(rfaF)
MMOB : F6R98_03545(waaF) F6R98_03865
MOZ : MoryE10_02280(waaF) MoryE10_12340
NWR : E3U44_07370 E3U44_15355
TNI : TVNIR_2693(rfaF_[H])
ALCA : ASALC70_02804(rfaF)
AEL : NCTC12917_00085(rfaF)
CDIZ : CEDIAZO_00372(rfaF)
NMM : NMBM01240149_0642(rfaF)
NMS : NMBM01240355_1450(rfaF)
NMQ : NMBM04240196_0691(rfaF)
NMZ : NMBNZ0533_1504(rfaF)
NMX : NMA510612_1944(rfaF)
NWE : SAMEA3174300_1065(rfaF)
NZO : SAMEA4504057_0872(rfaF)
NCI : NCTC10296_02360(rfaF)
NCZ : NCTC10294_01003(rfaF)
NANI : NCTC12227_01087(rfaF)
VFF : VITFI_CDS2401 VITFI_CDS2402
ECOR : SAMEA4412678_1221(rfaF)
CCAH : DWG20_06045 DWG20_11525(waaF)
CHRO : CXB49_12105(waaF) CXB49_18050
BMV : BMASAVP1_A0586(rfaF)
BML : BMA10229_A2419(rfaF)
BPS : BPSL0791(waaF) BPSS0425
BPM : BURPS1710b_0990(rfaF) BURPS1710b_A1967(rfaF)
BPL : BURPS1106A_0832(rfaF) BURPS1106A_A0576
BPD : BURPS668_0828(rfaF) BURPS668_A0669
BPZ : BP1026B_I2759(waaF) BP1026B_II0476
BPQ : BPC006_I0822 BPC006_II0623
BTE : BTH_I0658(rfaF) BTH_II1978
BTHA : DR62_07745 DR62_1853
BOK : DM82_184(rfaF) DM82_4504
PSPU : NA29_03310 NA29_09795
PFG : AB870_05125 AB870_10355
PLG : NCTC10937_00691(rfaF)
LMIR : NCTC12852_00577 NCTC12852_02111(rfaQ)
VTR : MYVALT_G_01730(rfaF)
BAV : BAV2018 BAV2230(waaF)
BTRM : SAMEA390648703775(rfaF)
AXY : AXYL_02017 AXYL_03114
AXX : ERS451415_01904(rfaF_1)
AAEG : RA224_11890 RA224_22710
PVAC : HC248_00103(rfaF_1)
RDP : RD2015_725 RD2015_726
AON : DEH84_13725 DEH84_13730
FAM : OYT1_ch0383 OYT1_ch1529
URU : DSM104443_02866(rfaF_1)
UPL : DSM104440_02565(rfaF)
AIQ : Azoinq_02715(waaF) Azoinq_08570 Azoinq_11365
MAMO : A6B35_19635 A6B35_26100
KAI : K32_02850 K32_20110(rfaF)
BSEP : HAP48_0047290(waaF)
BCAN : BcanWSM471_26305(waaF)
XDI : EZH22_20510(waaF) EZH22_24875
TSV : DSM104635_02585(rfaF)
HPO : HMPREF4655_21381(rfaF)
HPX : HMPREF0462_1203(rfaF)
HCB : HCBAA847_0994 HCBAA847_1217
HCL : NCTC13205_00278(rfaF)
HSH : NHP194022_13230(rfaF)
HPUL : NCTC13154_00428(rfaF)
CJV : MTVDSCj20_1153(waaF)
CFF : CFF8240_1411(rfaF) CFF8240_1607
CFT : CFF04554_1423 CFF04554_1610
CFV : CFVI03293_1449(waaF) CFVI03293_1632
CFX : CFV97608_1549(waaF) CFV97608_1735
CAMP : CFT03427_1374(waaF) CFT03427_1560
CFP : CR44_06950 CR44_07910
CCOC : CCON33237_0433(waaF)
CLR : UPTC16701_1205(waaF)
CLM : UPTC16712_1237(waaF)
CAMR : CAQ16704_1247(waaF)
CHV : CHELV3228_0509(waaF)
CPIN : CPIN18020_1352(waaF)
CAMZ : CVIC12175_0221(waaF)
ALK : ALEK_1135 ALEK_2530(waaF)
HEBR : AEBR_2075(waaF) AEBR_2870
HCJ : HCR_14790 HCR_17520(waaF)
NAP : C3L23_08540 C3L23_08850(waaF)
DAV : DESACE_05455 DESACE_05460
GEF : FO488_01035 FO488_03010(waaF)
GEO : Geob_0668 Geob_2111 Geob_2115
PSYF : N1030_00375 N1030_02830
DSB : LN040_00820 LN040_16805
PSEL : GM415_03050 GM415_09350
PSEF : PSDVSF_07810 PSDVSF_25240
PPOR : JCM14722_05400 JCM14722_20120
PTHE : LF599_01470(waaF) LF599_11125
PBIZ : LWC08_00590 LWC08_03265
CLIH : KPS_003482 KPS_003592(waaF)
DOV : DSCO28_11440(rfaF_1)
DMP : FAK_22670(rfaF) FAK_22690
BSTO : C0V70_02240 C0V70_17755
SBF : JCM31447_04430 JCM31447_14880
PIJ : QEJ31_08040 QEJ31_11660
SAQI : AXG55_00820 AXG55_09160
VRM : 44547418_00024(rfaC_1) 44547418_00028(rfaF_2) 44547418_00769(rfaQ)
VDN : NCTC11831_01188(rfaQ_1)
MHW : ACT01_00300 ACT01_07700
SELT : BCS37_01270 BCS37_01300
SDIA : QU667_00875 QU667_00880
MANA : MAMMFC1_02284(rfaF_3) MAMMFC1_02295(rfaQ_4)
AIN : Acin_0069 Acin_0847(waaF)
PFAC : PFJ30894_00055(rfaQ)
KBB : ccbrp13_29040 ccbrp13_29050 ccbrp13_29060 ccbrp13_29080
TNR : Thena_0130 Thena_0850 Thena_1397 Thena_1506 Thena_1663
TACI : TDSAC_0119 TDSAC_1007 TDSAC_1371 TDSAC_1485 TDSAC_1632
RPOR : RHAB15C_0001248 RHAB15C_0001249
VEG : SAMN05444156_0352 SAMN05444156_1410 SAMN05444156_1648
FPES : NXS98_01940(waaF) NXS98_11105(waaF)
SDYN : Mal52_56800(rfaF_2)
PLON : Pla110_29550(rfaF_2)
KST : KSMBR1_1397(rfaF) KSMBR1_3211(rfaF)
BPIT : BPIT_07130 BPIT_09540 BPIT_30860 BPIT_33880
JET : L3J17_02535 L3J17_09625(waaF)
ALUS : STSP2_02126(rfaF_1)
LPRO : PQO03_11110 PQO03_14605(waaF)
LKB : LPTSP3_g17240(rfaF) LPTSP3_g20900
BHY : BHWA1_00299(rfaC2) BHWA1_01247
BHD : BHYOB78_01490 BHYOB78_09830
BPO : BP951000_0118(rfaC2) BP951000_0475(rfaF) BP951000_0666(rfaF)
BPJ : B2904_orf1410 B2904_orf2035 B2904_orf916
BPIP : BPP43_00645 BPP43_02505 BPP43_11830
BPW : WESB_1321 WESB_1769 WESB_1979
BIP : Bint_0606 Bint_0820(rfaF) Bint_1294(rfaC2)
BHP : BHAMNSH16_10225 BHAMNSH16_13615
GEX : GETHOR_05320 GETHOR_09580(rfaF) GETHOR_13560 GETHOR_21230(waaF)
GEP : Q9293_07840 Q9293_07845 Q9293_12670
MSIL : METEAL_15960 METEAL_16940 METEAL_41760(waaF_2)
MSEA : METESE_12780(opsX) METESE_15630 METESE_38080
EPO : Epro_0320 Epro_0321(waaF) Epro_0322(waaF) Epro_0542(rfaF)
FUL : C4N20_05495 C4N20_05980
FPEI : C4N17_00405 C4N17_01915
FPOL : ERS445057_01759(rfaQ_4)
STR : Sterm_3090 Sterm_3091
HABY : HLVA_04120 HLVA_06550(waaC) HLVA_16960
BLQ : L21SP5_00037(rfaQ_1)
NKO : Niako_1987 Niako_2166
PSEG : D3H65_10855 D3H65_25415 D3H65_30430
THEO : IMW88_02170 IMW88_03945
SPIK : EXU85_21650 EXU85_26960
SFOL : H3H32_17535 H3H32_23015
SENF : GJR95_12835 GJR95_34990
HAEI : MUN82_00450 MUN82_00455
KOS : KORDIASMS9_02552(rfaF)
KAN : IMCC3317_43740(rfaF_2)
FBU : UJ101_00135(waaF|rfaF)
CACI : CLOAM0418 CLOAM1569 CLOAM1695
DIN : Selin_0540 Selin_0541
DDF : DEFDS_0333 DEFDS_1147
GTL : EP073_05935 EP073_13065(waaF)
MSCH : N508_001325(rfaF_1)
NMV : NITMOv2_3527(rfaF_gmhB)
NKF : Nkreftii_001064 Nkreftii_001209 Nkreftii_001211
NALL : PP769_00050 PP769_12840(waaF)
NVA : G3M78_05370(waaF) G3M78_07255
MFE : Mefer_0512 Mefer_0513
MJH : JH146_0064 JH146_0065
MMAD : MMJJ_17650(rfaF_1) MMJJ_17660(rfaF_2)
» show all
Taxonomy
Reference
Authors
Allen AG, Isobe T, Maskell DJ.
Title
Identification and cloning of waaF (rfaF) from Bordetella pertussis and use to generate mutants of Bordetella spp. with deep rough lipopolysaccharide.
Journal
Sequence
Reference
Authors
Bauer BA, Lumbley SR, Hansen EJ.
Title
Characterization of a WaaF (RfaF) homolog expressed by Haemophilus ducreyi.
Journal
Sequence
Reference
Authors
Gronow S, Brabetz W, Brade H
Title
Comparative functional characterization in vitro of heptosyltransferase I (WaaC) and II (WaaF) from Escherichia coli.
Journal
Reference
Authors
Gronow S, Oertelt C, Ervela E, Zamyatina A, Kosma P, Skurnik M, Holst O.
Title
Characterization of the physiological substrate for lipopolysaccharide heptosyltransferases I and II.
Journal
J Endotoxin Res 7:263-70 (2001)
Reference
Authors
Oldfield NJ, Moran AP, Millar LA, Prendergast MM, Ketley JM.
Title
Characterization of the Campylobacter jejuni heptosyltransferase II gene, waaF, provides genetic evidence that extracellular polysaccharide is lipid A core independent.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.99.24