KEGG ENZYME: 2.5.1.111

ENZYME: 2.5.1.111

Entry

EC 2.5.1.111                Enzyme

Name

4-hydroxyphenylpyruvate 3-dimethylallyltransferase;
CloQ;
4HPP dimethylallyltransferase;
NovQ;
dimethylallyl diphosphate:4-hydroxyphenylpyruvate 3-dimethylallyltransferase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

prenyl-diphosphate:3-(4-hydroxyphenyl)pyruvate 3'-prenyltransferase

Reaction(IUBMB)

prenyl diphosphate + 3-(4-hydroxyphenyl)pyruvate = diphosphate + 3-(4-hydroxy-3-prenylphenyl)pyruvate [RN:R06757]

Reaction(KEGG)

R06757

Substrate

prenyl diphosphate [CPD:C00235];
3-(4-hydroxyphenyl)pyruvate [CPD:C01179]

Product

diphosphate [CPD:C00013];
3-(4-hydroxy-3-prenylphenyl)pyruvate [CPD:C12456]

Comment

The enzyme's product feeds into the biosynthesis of the aminocoumarin antibiotics clorobiocin and novobiocin [1].

History

EC 2.5.1.111 created 2013

Pathway

ec00401

Novobiocin biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K12707

4-hydroxyphenylpyruvate 3-dimethylallyltransferase

Genes

NGV:	CDO52_02230

Reference

1 [PMID:12618544]

Authors

Pojer F, Wemakor E, Kammerer B, Chen H, Walsh CT, Li SM, Heide L.

Title

CloQ, a prenyltransferase involved in clorobiocin biosynthesis.

Journal

Proc Natl Acad Sci U S A 100:2316-21 (2003)
DOI:10.1073/pnas.0337708100

Sequence

[ag:AAN65239]

Reference

2 [PMID:17077503]

Authors

Keller S, Pojer F, Heide L, Lawson DM

Title

Crystallization and preliminary X-ray analysis of the aromatic prenyltransferase CloQ from the clorobiocin biosynthetic cluster of Streptomyces roseochromogenes.

Journal

Acta Crystallogr Sect F Struct Biol Cryst Commun 62:1153-5 (2006)
DOI:10.1107/S1744309106042527

Reference

3 [PMID:20946900]

Authors

Metzger U, Keller S, Stevenson CE, Heide L, Lawson DM

Title

Structure and mechanism of the magnesium-independent aromatic prenyltransferase CloQ from the clorobiocin biosynthetic pathway.

Journal

J Mol Biol 404:611-26 (2010)
DOI:10.1016/j.jmb.2010.09.067

Sequence

[ag:AAN65239]