KEGG ENZYME: 2.5.1.117

ENZYME: 2.5.1.117

Entry

EC 2.5.1.117                Enzyme

Name

homogentisate solanesyltransferase;
HST;
PDS2 (gene name)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

all-trans-nonaprenyl-diphosphate:homogentisate nonaprenyltransferase

Reaction(IUBMB)

all-trans-nonaprenyl diphosphate + homogentisate = diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 [RN:R08782]

Reaction(KEGG)

R08782

Substrate

all-trans-nonaprenyl diphosphate [CPD:C04145];
homogentisate [CPD:C00544]

Product

diphosphate [CPD:C00013];
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol [CPD:C17570];
CO2 [CPD:C00011]

Comment

Requires Mg2+ for activity. Part of the biosynthesis pathway of plastoquinol-9. The enzymes purified from the plant Arabidopsis thaliana and the alga Chlamydomonas reinhardtii are also active in vitro with unsaturated C10 to C20 prenyl diphosphates, producing main products that are not decarboxylated [2].

History

EC 2.5.1.117 created 2014

Pathway

ec00130

Ubiquinone and other terpenoid-quinone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K12501

homogentisate solanesyltransferase

Genes

ATH:	AT3G11945(HST)

ALY:

9320940

CRB:

17893368

CSAT:

104745405 104764953 104776009

EUS:	EUTSA_v10020917mg

BRP:	103859421 103870296

BNA:	106353069 106401877 106415089 106452511

BOE:	106295456 106328784

RSZ:	108857256 108861640 130495167

THJ:

104799273

CPAP:

110811676

CIT:

102623177

CIC:	CICLE_v10011942mg

PVY:	116123782 116141098

MINC:

123217947

TCC:

18599202

GRA:

105799584

GHI:	107889470 107891223

GAB:

108454348

HSYR:

120159828 120202024

DZI:

111311614

EGR:

104446383

GMX:	106794098 732619(VTE2-2)

GSJ:	114368608 114391749

PVU:	PHAVU_007G263400g PHAVU_007G263600g

VRA:

106772791

VAR:

108324919

VUN:

114189752

VUM:

124845334

CCAJ:

109815147

APRC:

113870943

MTR:

25483545

TPRA:

123906043

CAM:

101499831

PSAT:

127098289

VVO:	131628171 131631878

LJA:	Lj5g3v0380030.1(Lj5g3v0380030.1)

ADU:

107488364

AIP:	107638265 107640277 107643163

AHF:	112740928 112749774 112749775 112801368

LANG:

109348270

PCIN:

129312483

QSA:	O6P43_005780

FVE:

101315076

RCN:

112191407

PPER:

18771788

PMUM:

103339596

PAVI:

110748815

PDUL:

117634837

MDM:	103413543 103453758

MSYL:

126594281 126600879

ZJU:

107432279

MNT:	112090276 112090288 112090338 112090624 112090625 112090629 112091786 112092455 112092457 112092653 112092669 112093398 112093399 112093962 21386351 21386352 21391268 21392968 21395652 21395653 21397213 21397216 21397218 21397221 21400881 21408641 21408642

CSAV:

115699217 115707809 115713148 115713171 115713185 115713205 115713215