KEGG   ENZYME: 2.5.1.124
Entry
EC 2.5.1.124                Enzyme                                 
Name
6-linalyl-2-O,3-dimethylflaviolin synthase;
Fur7;
6-(3,7-dimethylocta-1,6-dien-3-yl)-5,7-dihydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranyl-diphosphate:2-O-methyl-3-methylflaviolin geranyltransferase (6-linalyl-2-O,3-dimethylflaviolin-forming)
Reaction(IUBMB)
geranyl diphosphate + 2-O,3-dimethylflaviolin = diphosphate + 6-linalyl-2-O,3-dimethylflaviolin [RN:R11086]
Reaction(KEGG)
R11086
Substrate
geranyl diphosphate [CPD:C00341];
2-O,3-dimethylflaviolin [CPD:C21001]
Product
diphosphate [CPD:C00013];
6-linalyl-2-O,3-dimethylflaviolin [CPD:C21002]
Comment
The enzyme is involved in biosynthesis of the polyketide-isoprenoid furaquinocin D in the bacterium Streptomyces sp. KO-3988. It catalyses the transfer of a geranyl group to 2-O,3-dimethylflaviolin to yield 6-linalyl-2-O,3-dimethylflaviolin and 7-O-geranyl-2-O,3-dimethylflaviolin (cf. EC 2.5.1.125, 7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase) in a 10:1 ratio.
History
EC 2.5.1.124 created 2014
Orthology
K21341  6-linalyl-2-O,3-dimethylflaviolin/7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase
Genes
SDV: BN159_7948
SQZ: FQU76_00200 FQU76_33540
SPAD: DVK44_34335
SMOB: J7W19_27640
SROI: IAG44_38270
SXT: KPP03845_300034(ppzP_1) KPP03845_300071(ppzP_2)
ABRY: NYE86_28205
ACTQ: OG417_42660
KBU: Q4V64_43050
MSAG: GCM10017556_12000
MENO: Jiend_53560
MCHL: PVK74_09525
PSUU: Psuf_091250 Psuf_091420
 » show all
Reference
1  [PMID:20937800]
  Authors
Kumano T, Tomita T, Nishiyama M, Kuzuyama T
  Title
Functional characterization of the promiscuous prenyltransferase responsible for furaquinocin biosynthesis: identification of a physiological polyketide substrate and its prenylated reaction products.
  Journal
J Biol Chem 285:39663-71 (2010)
DOI:10.1074/jbc.M110.153957
  Sequence
[ag:BAF02319]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.124
IUBMB Enzyme Nomenclature: 2.5.1.124
ExPASy - ENZYME nomenclature database: 2.5.1.124
BRENDA, the Enzyme Database: 2.5.1.124

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (17)   
Protein sequence (4)   
   UniProt (3)   
   SWISS-PROT (1)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (3)   
   InterPro (3)   
All databases (33)   

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