Entry
Name
3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase;
3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase;
2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase;
Kdn 9-P synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
phosphoenolpyruvate:D-mannose-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
phosphoenolpyruvate + D-mannose 6-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate [RN:
R11439 ]
Reaction(KEGG)
Substrate
Product
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate [CPD:
C21383 ];
phosphate [CPD:
C00009 ]
Comment
The enzyme participates in the biosynthesis of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). The human sialic acid synthase (EC
2.5.1.57 ) is also able to catalyse the reaction. Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
History
EC 2.5.1.132 created 2016
Pathway
ec00520 Amino sugar and nucleotide sugar metabolism
Orthology
K21279 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase
Genes
TPAI : 128089605 128089615
LMUT : 125687047 125687392
XLA : 432051(nans.S) 447417(nans.L)
DRE : 322780(nansa) 492779(nansb)
SRX : 107723182 107754352 107754390 107758866
SANH : 107665955 107686966 107686967 107692601
SGH : 107557947 107566238 107566239
CCAR : 109076464 109090623 109090659
CAUA : 113044320 113066551 113066555 113066556 113066635 113085422 113105679
CGIB : 127946856 127946857 127948763 127975766
LROH : 127156361(nansb) 127172436(nansa)
OMC : 131524664 131534998(nansb) 131541588(nansa)
PPRM : 120475377(nansb) 120475384 120475385 120475386 120478311(nansa)
RKG : 130097610 130097653 130106509 130106510
MAMB : 125247499 125247713 125247908 125247921 125248041 125251616 125251645 125272478(nansa)
CIDE : 127507296 127519832
MASI : 127443667 127445253
TDW : 130407907(nansa) 130414328 130414329 130414351 130414352 130414355 130414375
MANU : 129433135 129433751 129444857(nansa) 129445965
IPU : 100528493(nansa) 108260162
IFU : 128603812 128604222(nansa)
SMEO : 124378730 124381237(nansa)
CMAO : 118811935 118811936 118816978(nansa)
EEE : 113568448(nans) 113589926
CGOB : 115010173 115010214
PGEO : 117439291(nansa) 117450755
GACU : 117555257 117561263(nansa) 117561638
AFB : 129095925 129096028(nansa)
MSAM : 119884880 119899378 119899379
SCHU : 122873785 122873786
CUD : 121507902 121508708 121508709
ONL : 100695579 100695847 100696106
OAU : 116310552 116310553 116310587
PRET : 103467988(nans) 103472627
CVG : 107083396(nans) 107083415 107083416
CTUL : 119787144 119787154 119787177
MCEP : 125003896 125004087 125004788
CSEM : 103384124 103384125
SSEN : 122770577 122771631
HHIP : 117769790 117769798
SMAU : 118312620 118312971
SSCV : 125969199 125969200
SBIA : 133506019 133506020
PTAO : 133476244 133476245
BPEC : 110166192 110166235
BSPL : 114858266 114858277 114858282
SASA : 100195066(sias) 106594767 106609889
STRU : 115191851 115202178 115202179 115202180 115202181
OMY : 110497423 110497424 110534455
OGO : 124001941 124001943 124012735
ONE : 115137363 115137722 115145762 115146546
OKE : 118362993 118362994 118395463
SALP : 111971593 112068285 112080022
SNH : 120034903 120051990 120052901
CCLU : 121534521 121535761 121535762
PSEX : 120532357 120532358 120532359
CMK : 103177631(nansa) 103177633
CPLA : 122539555(nansa) 122547124
BBEL : 109471483 109471485
DSI : Dsimw501_GD18832(Dsim_GD18832)
APLN : 108741788 112904754
PMAC : 106708951 106709065
PPOT : 106100777 106100789
PPOI : 119112814 119113236
ABRU : 129958113 129958114 129958115
EHX : EMIHUDRAFT_437804(NEUB)
HEBR : AEBR_0577 AEBR_2874
PSEL : GM415_02085 GM415_02270
BTHO : Btheta7330_01302(neuB_1) Btheta7330_02995(neuB_2)
BCEL : BcellWH2_03092(neuB)
PCLR : PC1C4_16490 PC1C4_23910
PRN : BW723_03025 BW723_09690
HWS : RNZ46_01605 RNZ46_07195
PTAN : CRYO30217_01041(neuB)
» show all
Taxonomy
Reference
Authors
Angata T, Nakata D, Matsuda T, Kitajima K, Troy FA 2nd
Title
Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis.
Journal
Reference
Authors
Lawrence SM, Huddleston KA, Pitts LR, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ
Title
Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability.
Journal
Sequence
Reference
Authors
Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D
Title
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.5.1.132