KEGG   ENZYME: 2.5.1.132
Entry
EC 2.5.1.132                Enzyme                                 
Name
3-deoxy-D-glycero-D-galacto-nonulopyranosonate 9-phosphate synthase;
3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase;
2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase;
Kdn 9-P synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
phosphoenolpyruvate:D-mannose-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase
Reaction(IUBMB)
phosphoenolpyruvate + D-mannose 6-phosphate + H2O = 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate [RN:R11439]
Reaction(KEGG)
R11439
Substrate
phosphoenolpyruvate [CPD:C00074];
D-mannose 6-phosphate [CPD:C00275];
H2O [CPD:C00001]
Product
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate [CPD:C21383];
phosphate [CPD:C00009]
Comment
The enzyme participates in the biosynthesis of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). The human sialic acid synthase (EC 2.5.1.57) is also able to catalyse the reaction. Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
History
EC 2.5.1.132 created 2016
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K05304  sialic acid synthase
K21279  3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase
Genes
HSA54187(NANS)
PTR743934(NANS)
PPS100982112(NANS)
GGO101124502(NANS)
PON100446862(NANS)
NLE100603154(NANS)
HMH116475313(NANS)
MCC715459(NANS)
MCF102120030(NANS)
MTHB126938070
MNI105477199(NANS)
CSAB103219150(NANS)
CATY105593048(NANS)
PANU101020165(NANS)
TGE112607835(NANS)
MLEU105549289(NANS)
RRO104657773(NANS)
RBB108539113(NANS)
TFN117098940(NANS)
PTEH111536614(NANS)
CANG105509947(NANS)
CJC100411585(NANS)
SBQ101027621(NANS)
CIMI108303891(NANS)
CSYR103273474(NANS)
MMUR105873791(NANS)
LCAT123645941(NANS)
PCOQ105805371(NANS)
OGA100951418(NANS)
MMU94181(Nans)
MCAL110292645(Nans)
MPAH110323062(Nans)
RNO298071(Nans)
MCOC116095967(Nans)
ANU117709646(Nans)
MUN110551128(Nans)
CGE100767837(Nans)
MAUA101830178(Nans)
PROB127224641(Nans)
PLEU114702354(Nans)
MORG121458558(Nans)
MFOT126509881
AAMP119826497(Nans)
NGI103749137(Nans)
HGL101721582(Nans)
CPOC100716456(Nans)
CCAN109697287(Nans)
DORD105990839(Nans)
DSP122121805(Nans)
PLOP125345837(Nans)
NCAR124964919
MMMA107147766(Nans)
OCU100356934
OPI101522937(NANS)
TUP102496776(NANS)
GVR103590728(NANS)
CFA481624(NANS)
CLUD112649641(NANS)
VVP112930767(NANS)
VLG121494904(NANS)
NPO129495242(NANS)
AML100471912(NANS)
UMR103678504(NANS)
UAH113260417(NANS)
UAR123781029(NANS)
ELK111146174
LLV125083268
MPUF101687668(NANS)
MNP132024576(NANS)
MLK131812492(NANS)
NVS122917426(NANS)
ORO101377441(NANS)
EJU114213569(NANS)
ZCA113934273(NANS)
MLX118017911(NANS)
NSU110581438(NANS)
LWW102730978(NANS)
FCA101092303(NANS)
PYU121034713(NANS)
PCOO112872235(NANS)
PBG122474611(NANS)
PVIV125149821(NANS)
LRUF124502196
PTG102952743(NANS)
PPAD109270098(NANS)
PUC125920084
AJU106981299
HHV120233531(NANS)
BTA540602(NANS)
BOM102266035(NANS)
BIU109563072(NANS)
BBUB102402717(NANS)
BBIS104993691(NANS)
CHX102171423(NANS)
OAS101104048(NANS)
BTAX128052274(NANS)
ODA120862645(NANS)
CCAD122452923(NANS)
MBEZ129556850(NANS)
SSC100155883(NANS)
CFR102511644(NANS)
CBAI105067382(NANS)
CDK105086903(NANS)
VPC102528094(NANS)
BACU103016138(NANS)
BMUS118897102(NANS)
LVE103074242(NANS)
OOR101286113(NANS)
DLE111187968(NANS)
PCAD102975186(NANS)
PSIU116755813(NANS)
NASI112392669(NANS)
ECB100064126(NANS)
EPZ103550229(NANS)
EAI106842931(NANS)
MYB102254698(NANS)
MYD102770256(NANS)
MMYO118667273(NANS)
MLF102435662(NANS)
PKL118716275(NANS)
EFUS103286401(NANS)
MNA107544993(NANS)
DRO112304493(NANS)
SHON118979589(NANS)
AJM119045927(NANS)
PDIC114509777(NANS)
PHAS123819942(NANS)
MMF118629683(NANS)
PPAM129079673(NANS)
HAI109386412(NANS)
RFQ117032312(NANS)
PALE102882391(NANS)
PGIG120597479(NANS)
PVP105296243(NANS)
RAY107511690(NANS)
MJV108386331(NANS)
TOD119231857(NANS)
SARA101558462(NANS)
LAV100659127(NANS)
TMU101361417
ETF101653381(NANS)
DNM101415935(NANS)
MDO100014569(NANS)
GAS123231260(NANS)
SHR100915225(NANS)
AFZ127560750
PCW110220562(NANS)
OAA100074951(NANS)
GGA427283(NANS)
PCOC116234839(NANS)
MGP100540972(NANS)
CJO107306381(NANS)
TPAI128089605 128089615
LMUT125687047 125687392
NMEL110389693(NANS)
APLA101793548(NANS)
ACYG106046483(NANS)
CATA118256861(NANS)
AFUL116500909(NANS)
TGU100227675(NANS)
LSR110472303(NANS)
SCAN103821217(NANS)
PMOA120509468(NANS)
OTC121334701(NANS)
PRUF121355663(NANS)
GFR102036907(NANS)
FAB101817049(NANS)
OMA130264714(NANS)
PHI102108606(NANS)
PMAJ107198262(NANS)
CCAE111940921(NANS)
CCW104689769(NANS)
CBRC103616433(NANS)
ETL114056942(NANS)
ZAB102065706(NANS)
ACHL103804865(NANS)
SVG106859673(NANS)
MMEA130577596(NANS)
HRT120765301(NANS)
FPG101910977(NANS)
FCH102058691(NANS)
CLV102088004(NANS)
EGZ104135026(NANS)
NNI104014067(NANS)
PCRI104025538(NANS)
PLET104620779(NANS)
EHS104517044(NANS)
PCAO104046970(NANS)
ACUN113489989(NANS)
TALA104366421(NANS)
PADL103923247(NANS)
AFOR103896158(NANS)
ACHC115336739(NANS)
HALD104312067(NANS)
HLE104830508(NANS)
AGEN126036494
GCL127027665
CCRI104155775(NANS)
CSTI104550675(NANS)
CMAC104481639(NANS)
FGA104074239(NANS)
GSTE104263825(NANS)
LDI104355132(NANS)
MNB103774718(NANS)
OHA104331297(NANS)
NNT104409114(NANS)
SHAB115601192(NANS)
DPUB104304859(NANS)
PGUU104469406(NANS)
ACAR104518859(NANS)
CPEA104394483(NANS)
AVIT104274354(NANS)
CVF104285719(NANS)
RTD128902703(NANS)
CUCA104059924(NANS)
TEO104375228(NANS)
BRHI104489142(NANS)
AAM106487451(NANS)
AROW112968978(NANS)
NPD112946284(NANS)
TGT104577698(NANS)
DNE112982754(NANS)
SCAM104151902(NANS)
ASN102371122(NANS)
AMJ102562418(NANS)
CPOO109323518(NANS)
CMY102930222(NANS)
CCAY125636602(NANS)
DCC119855742(NANS)
CPIC101940249(NANS)
TST117878892(NANS)
CABI116832497(NANS)
MRV120408042(NANS)
ACS100558551(nans)
ASAO132768113(NANS)
PVT110077827(NANS)
SUND121924222(NANS)
PBI103051012(NANS)
PMUR107293127(NANS)
CTIG120308567(NANS)
TSR106556782(NANS)
PGUT117661676(NANS)
APRI131193653(NANS)
PTEX113444069(NANS)
NSS113415520(NANS)
VKO123030229(NANS)
PMUA114587657(NANS)
PRAF128405086(NANS)
ZVI118097903(NANS)
HCG128346307(NANS)
GJA107122992(NANS)
STOW125437185(NANS)
EMC129334514(NANS)
XLA432051(nans.S) 447417(nans.L)
XTR100492893(nans)
NPR108783786(NANS)
RTEM120946942(NANS)
BBUF120989333(NANS)
BGAR122920937(NANS)
MUO115459142 115463653
GSH117347248 117347256
DRE322780(nansa) 492779(nansb)
SRX107723182 107754352 107754390 107758866
SANH107665955 107686966 107686967 107692601
SGH107557947 107566238 107566239
CCAR109076464 109090623 109090659
CAUA113044320 113066551 113066555 113066556 113066635 113085422 113105679
CGIB127946856 127946857 127948763 127975766
PTET122322880(nansa)
LROH127156361(nansb) 127172436(nansa)
OMC131524664 131534998(nansb) 131541588(nansa)
PPRM120475377(nansb) 120475384 120475385 120475386 120478311(nansa)
RKG130097610 130097653 130106509 130106510
MAMB125247499 125247713 125247908 125247921 125248041 125251616 125251645 125272478(nansa)
CIDE127507296 127519832
MASI127443667 127445253
TROS130553152(nansa)
TDW130407907(nansa) 130414328 130414329 130414351 130414352 130414355 130414375
MANU129433135 129433751 129444857(nansa) 129445965
IPU100528493(nansa) 108260162
IFU128603812 128604222(nansa)
PHYP113531522(nans)
SMEO124378730 124381237(nansa)
TFD113635339(nansa)
TVC132842025(nansa)
AMEX111195185(nans)
CMAO118811935 118811936 118816978(nansa)
EEE113568448(nans) 113589926
CHAR105903578(nansa)
TRU778024(nans)
TFS130527938(nansa)
TNGGSTEN00033532G001
LCO104922341(nans)
TBEN117474709(nansa)
CGOB115010173 115010214
PGEO117439291(nansa) 117450755
GACU117555257 117561263(nansa) 117561638
EMAC134864542(nansa)
ELY117254746(nansa)
EFO125885917(nansa)
PLEP121942582(nansa)
SLUC116042899(nansa)
ECRA117956637(nansa)
ESP116698406(nans)
PFLV114570372(nans)
GAT120825501 120825503
PPUG119218410(nansa)
AFB129095925 129096028(nansa)
CLUM117737471(nansa)
PSWI130190092(nansa)
MSAM119884880 119899378 119899379
SCHU122873785 122873786
CUD121507902 121508708 121508709
ALAT119028006
MZE101481190 106674567
ONL100695579 100695847 100696106
OAU116310552 116310553 116310587
OLA101166198(nans)
OML112137589(nansa)
CSAI133444310(nansa)
XMA102234709(nans)
XCO114145362(nans)
XHE116720640(nans)
PRET103467988(nans) 103472627
PFOR103148741(nans)
PLAI106938624(nans)
PMEI106905478(nans)
GAF122829775(nansa)
PPRL129367361(nansa)
CVG107083396(nans) 107083415 107083416
CTUL119787144 119787154 119787177
GMU124868545 124868562
NFU107390917 107390934
KMR108241432 108241509
ALIM106528334(nans)
NWH119422378 119422379
AOCE111575007(nans)
MCEP125003896 125004087 125004788
CSEM103384124 103384125
POV109627210 109627438
SSEN122770577 122771631
HHIP117769790 117769798
HSP118122966 118126039
SMAU118312620 118312971
LCF108885367 108885368
SDU111229256 111229269
SLAL111659703
XGL120800959(nansa)
HCQ109519806 109519931
SSCV125969199 125969200
SBIA133506019 133506020
PEE133404376 133404378
PTAO133476244 133476245
BPEC110166192 110166235
MALB109953770(nans)
BSPL114858266 114858277 114858282
SJO128374734(nansa)
SASA100195066(sias) 106594767 106609889
STRU115191851 115202178 115202179 115202180 115202181
OTW112231840 112261351
OMY110497423 110497424 110534455
OGO124001941 124001943 124012735
ONE115137363 115137722 115145762 115146546
OKI109894131 109901155
OKE118362993 118362994 118395463
SALP111971593 112068285 112080022
SNH120034903 120051990 120052901
CCLU121534521 121535761 121535762
ELS105022900(nans)
SFM108920829
PKI111855408(nans)
AANG118227907(nansa)
LOC102687418(nans)
PSPA121319344(nansa)
ARUT117420829(nansa)
PSEX120532357 120532358 120532359
CMK103177631(nansa) 103177633
RTP109938218(nansa)
CPLA122539555(nansa) 122547124
HOC132833232(nansa)
LERI129702205(nansa)
PMRN116951617(NANS)
LRJ133340871
BFO118412951 118412952
BBEL109471483 109471485
SCLV120347367
SPU577884
LPIC129272734
APLC110979925
AJC117102584
SKO100367009 100376912
DMEDmel_CG5232(NANS)
DER6553702
DSE6606666
DSIDsimw501_GD18832(Dsim_GD18832)
DYADyak_GE26192
DSR110190443
DPO4800832
DPE6598731
DMN108156913
DWI6650267
DGR6568185
DMODmoj_GI24828
DAZ108621816
DNV108653385
DHE111601415
CCAT101459749
BOD106619099
BDR105230863
RZE108365099
AOQ129252978
TDA119676011
MDE101899077
SCAC106086863
LCQ111687367
LSQ119609198
GFS119638352
ECOE129939471
CLON129606515
HIS119658663
AGA133390932
ACOZ120950612
AARA120897604
AMER121589583
ASTE118508544
AFUN125763207
AMOU128309712
AALI118457210
AAG5563645
AALB109400878
CQUCpipJ_CPIJ013964
CPII120415920
CNS116345828
BCOO119073869
TCA103312199
DPA109539228
SOY115879752
AGRG126744310
ATD109597067
CSET123315673
AGB108917229
LDC111503205
NVL108567369
APLN108741788 112904754
PPYR116164831
BMOR101744099
BMAN114246626
MSEX115444962
DPLKGM_201756
BANY112054184
MJU123873286
NIQ126781032
VCD124533422
MCIX123656177
PMAC106708951 106709065
PPOT106100777 106100789
PXU106124172 106124788
PRAP110994857
PBX123716686
PNAP125054681
ZCE119829783
CCRC123693416
LSIN126969391
HAW110380482
HZE124629863
TNL113496613 113506267
SLIU111353605
OFU114364386
PXY105391284
PGW126373167 126377162
CCRN123298907
API100166349 100570600
DNX107161705
AGS114120104
RMD113549718
ACOO126833023
DVT126896132
BTAB109035180
DCI103520284
CLEC106666066
HHAL106681070
NLU111058090
HVI124352678
PHUPhum_PHUM018360
FOC113212662
TPAL117647422
ZNE110829049
CSEC111874253
SGRE126267101
BROR134530381
IEL124155457
FCD110842189
DPXDAPPUDRAFT_300651
DMK116933060
DPZ124349840
PVM113802701
PJA122265930
PCHN125046868
PMOO119575012
HAME121873235
PCLA123769285
CQD128690230
PTRU123507890
ESN126997930
HAZT108677748
EAF111695997
PPOI119112814 119113236
VDE111250001
VJA111258697
TUT107368038
CSCU111619307
PTEP107452120
ABRU129958113 129958114 129958115
UDV129218419
SDM118205491
LPOL106468194
MMER123559815
AAFAURANDRAFT_30675
EHXEMIHUDRAFT_437804(NEUB)
NCOAAW31_00110
NMUNmul_A0408
NLCEBAPG3_000870
SLACSKTS_36140
EAKEKH55_4784
EAHFA04_24335
RLGRleg_0440
RHVBA939_07200
RRGJ3P73_04755
RPERPE_4236
MMYRMXMO3_03623
BVRBVIR_1970
BLAGBLTE_00400(neuB)
HDIHDIA_0896(pseI)
LABRCHH27_23610
LAGGB0E33_04290
MALGMALG_05073
PSEBEOK75_20575
CBOTATE48_13380
SPANAWL63_07225
SPZRG5C33_06875
PALGHFP57_17520
CMANA9D14_11725
RCERC1_3771(nans)
DEXHWD60_03420
ARCABLL_2687
AHSAHALO_2546
AMYTAMYT_2597
HEBRAEBR_0577 AEBR_2874
PCAPcar_1277(neuB)
DFLDFE_1272
DMADMR_13530
DCBC3Y92_14295
DGGDGI_4066
DMSE8L03_20250
DAFDesaf_0142
DASDaes_2970
DPIBN4_12645
DEJAWY79_17810
PPRFDPRO_1430
PSELGM415_02085 GM415_02270
DDNDND132_2824
PSEFPSDVSF_27550
PPORJCM14722_23280
PNWSYK_28560
PTHELF599_15630
DSXGD604_00905
DSDGD606_11120
DVMDvMF_1832
TAVG4V39_08720
HLIHLI_08585
GRCGI584_08485
BOUI5818_06175
PYGAWM70_17110
ACELacsn021_05140
TTOThethe_00855
CLCCalla_1077
SLAUSLA_6887
RTXTI83_02490
RTCAPU90_03985
RRYC1O28_12555
MPROBJP34_26850
TBETrebr_1643
BPAAK7I13_00555
SSMSpirs_4263
BHPBHAMNSH16_00325
BTHBT_1714
BTHOBtheta7330_01302(neuB_1) Btheta7330_02995(neuB_2)
BHLBache_2153
BCELBcellWH2_03092(neuB)
BISDXK01_006200
BEGINE88_01921(neuB)
BSTEK6V31_10255
BFEK6V30_22135
BSABacsa_3466
BVSBARVI_00420
PCLRPC1C4_16490 PC1C4_23910
ANFAQPE_2133
PGINFRZ67_17740
SHTKO02_22675
MUCMuYL_3260
MGKFSB76_19830
CAMUCA2015_3635
RHOZGXP67_24460
RSIRunsl_2328
RUNDR864_20420
RUPDTQ70_21560
RSRT7867_12995
FAXFUAX_28080
FJGBB050_02206(legI)
FCOFCOL_12635
FGLEM308_00620
FCMBIW12_03115
FFAFFWV33_07925
FCRHYN56_01615
FENJ0383_14490
FCVAWN65_10295
FAZM0M57_00280
FCSTRV642_0311
FPECQ1W71_13450
CATCA2559_07305
KDIKrodi_2064
DOKMED134_13631(neuB)
DDOI597_1525(legI)
DODDCS32_01450
LNUN7U66_19210
ASLAeqsu_2923
AICJK629_04875
NDODDD_2293
NOMAAT17_10860
NSDBST91_07935
NOBCW736_00515
NULR1T42_01410
PRNBW723_03025 BW723_09690
LUTLupro_02285
SMISLDL76_16005
OLLCW732_09090
TAJC1A40_00900
AUEC5O00_09755
AQAD1815_16910
EMARD1013_15690
MESQC7H62_1954
SINHLS482_08950
SABUMBM09_06180
ALUTO5O44_12210
HWSRNZ46_01605 RNZ46_07195
FBQD1817_12910
PTANCRYO30217_01041(neuB)
BBAUAEM51_01345
BGWVE98_C0001G0439
MACMA_3767
MVCMSVAZ_0733
MEKMSKOL_0716
MHAZBHR79_03025
MAXMMALV_05370
 » show all
Reference
1  [PMID:10438460]
  Authors
Angata T, Nakata D, Matsuda T, Kitajima K, Troy FA 2nd
  Title
Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis.
  Journal
J Biol Chem 274:22949-56 (1999)
DOI:10.1074/jbc.274.33.22949
Reference
2  [PMID:10749855]
  Authors
Lawrence SM, Huddleston KA, Pitts LR, Nguyen N, Lee YC, Vann WF, Coleman TA, Betenbaugh MJ
  Title
Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability.
  Journal
J Biol Chem 275:17869-77 (2000)
DOI:10.1074/jbc.M000217200
  Sequence
[hsa:54187]
Reference
3  [PMID:18804026]
  Authors
Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D
  Title
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
  Journal
Chem Biol 15:893-7 (2008)
DOI:10.1016/j.chembiol.2008.08.005
  Sequence
[bth:BT_1714]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.132
IUBMB Enzyme Nomenclature: 2.5.1.132
ExPASy - ENZYME nomenclature database: 2.5.1.132
BRENDA, the Enzyme Database: 2.5.1.132

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